scholarly journals Earth Dreams: Reimagining ARPA for Health of People, Places and Planet

2021 ◽  
Vol 18 (23) ◽  
pp. 12788
Author(s):  
Alan C. Logan ◽  
Brian M. Berman ◽  
Susan L. Prescott
Keyword(s):  
Early Life ◽  
New Technologies ◽  
Communicable Disease ◽  
Value Systems ◽  
Early Interventions ◽  
International Collaborations ◽  
Life Course Health ◽  
The Many ◽  
Structural Inequities ◽  
Non Communicable Disease

Bold new approaches are urgently needed to overcome global health challenges. The proposed Advanced Research Projects Agency for Health (ARPA-H) is intended to provide rapid health breakthroughs. While new technologies for earlier disease detection and more effective treatment are critical, we urge equal attention be given to the wider (physical, emotional, social, political, and economic) environmental ecosystems driving the non-communicable disease (NCD) crisis in the first place. This requires an integrated, cross-sectoral vision that spans the interwoven connections affecting health across the scales of people, places, and planet. This wider “exposome” perspective considers biopsychosocial factors that promote resilience and reduce vulnerabilities of individuals and communities over time—the many variables driving health disparities. Since life course health is strongly determined by early life environments, early interventions should be prioritized as a matter of effectiveness and social justice. Here, we explore the origins of the Advanced Research Project Agency and point to its potential to build integrated solutions, with wisdom and ethical value systems as a compass. Since the planned ARPA-H is anticipated to spawn international collaborations, the imagined concept is of relevance to a broad audience of researchers. With appropriate input, the quest for health equity through personalized, precision medicine while deconstructing unacceptable structural inequities may be accelerated.

scholarly journals Precision Medicine, Developmental Plasticity and Prevention of Non-Communicable Disease

2020 ◽  
Author(s):  
Carol Wang ◽  
John Attia ◽  
Stephen Lye ◽  
Wendy Oddy ◽  
Lawrence Beilin ◽  
...  
Keyword(s):  
Precision Medicine ◽  
Early Life ◽  
Developmental Plasticity ◽  
Communicable Disease ◽  
Adult Health ◽  
Lower Systolic Blood Pressure ◽  
Adult Disease ◽  
Healthy Nutrition ◽  
Non Communicable Disease

Abstract Background: It is well established that genetics, environment, and interplay between them play crucial roles in adult disease. We aimed to evaluate the role of genetics, early life nutrition, and interaction between them, on optimal adult health. Methods: As part of a large international consortium (n~154,000), we identified 60 SNPs associated with both birthweight and adult disease. Utilising the Raine Study, we developed a birthweight polygenic score (BW-PGS) based the 60 SNPs and examined relationships between BW-PGS and adulthood cardiovascular risk factors, specifically evaluating interactions with early life nutrition. Findings: Healthy nutrition was beneficial for all individuals; longer duration of any breastfeeding was associated with lower BMI and lower Systolic Blood Pressure in those with higher BW-PGS. Interpretation: Optimal breastfeeding offers the greatest benefit to reduce adult obesity and hypertension in those genetically predisposed to high birthweight. This provides an example of how precision medicine in early life can improve adult health.

The birth and future health of DOHaD

2015 ◽  
Vol 6 (5) ◽  
pp. 434-437 ◽  
Author(s):  
M. Hanson
Keyword(s):  
20Th Century ◽  
Biomedical Research ◽  
Early Life ◽  
Clinical Medicine ◽  
Communicable Disease ◽  
Future Health ◽  
Late 20Th Century ◽  
Unique Aspect ◽  
Underlying Mechanisms ◽  
Non Communicable Disease

Professor David Barker, CBE, FRS, made an enormous contribution to biomedical research, which helped to change its direction and assisted translation to clinical medicine in the area of non-communicable disease (NCD). In this paper, I briefly note some of the studies, which led to his work, and describe how the underlying mechanisms came to be investigated by fetal physiologists. This is a unique aspect of the change in scientific emphasis, from a gene-centric and adult lifestyle view of NCD to a more holistic perspective, which placed emphasis on the importance of development that took place in the late 20th century. Early this century, the DOHaD Society was formed: I discuss some aspects of the formation of the Society and note the important role it is now playing in addressing the need to find early-life interventions to reduce NCD. This forms part of the unique legacy that David Barker has left to science and medicine.

scholarly journals Precision Medicine, Developmental Plasticity and Prevention of Non-Communicable Disease

2021 ◽  
Author(s):  
Carol A Wang ◽  
John R Attia ◽  
Stephen J Lye ◽  
Wendy H Oddy ◽  
Lawrence Beilin ◽  
...  
Keyword(s):  
Precision Medicine ◽  
Early Life ◽  
Developmental Plasticity ◽  
Communicable Disease ◽  
Adult Health ◽  
Lower Systolic Blood Pressure ◽  
Adult Disease ◽  
Healthy Nutrition ◽  
Non Communicable Disease

Abstract Background: It is well established that genetics, environment, and interplay between them play a crucial role in adult disease. We aimed to evaluate the role of genetics, early life nutrition, and the interaction between them, on optimal adult health. Methods: As part of a large international consortium (n~154,000), we identified 60 SNPs associated with both birthweight and adult disease. Utilising the Raine Study, we developed a birthweight polygenic score (BW-PGS) based on the 60 SNPs and examined relationships between BW-PGS and adulthood cardiovascular risk factors, specifically evaluating interactions with early life nutrition. Findings: Healthy nutrition was beneficial for all individuals; longer duration of any breastfeeding was particularly associated with lower BMI and lower Systolic Blood Pressure in those with higher BW-PGS. Interpretation: Optimal breastfeeding offers the greatest benefit to reduce adult obesity and hypertension in those genetically predisposed to high birthweight. This provides an example of how precision medicine in early life can improve adult health.

Vamping the Stage

2017 ◽  
Keyword(s):  
Popular Music ◽  
New Technologies ◽  
The Philippines ◽  
Women Performers ◽  
New Music ◽  
Women's Voices ◽  
Post Colonial ◽  
Musical Practices ◽  
The Many ◽  
Late Modern

Vamping the Stage is the first book-length historical and comparative examination of women, modernity, and popular music in Asia. This book documents the many ways that women performers have supported, challenged, and undermined representations of existing gendered norms in the entertainment industries of China, Japan, India, Indonesia, Iran, Korea, Malaysia, and the Philippines. The case studies in this volume address colonial, post-colonial, as well as late modern conditions of culture as they relate to women’s musical practices and their changing social and cultural identities throughout Asia. Female entertainers were artistic pioneers of new music, new cinema, new forms of dance and theater, and new behavior and morals. Their voices, mediated through new technologies of film, radio, and the phonograph, changed the soundscape of global popular music and resonate today in all spheres of modern life. These female performers were not merely symbols of times that were rapidly changing. They were active agents in the creation of local performance cultures and the rise of a region-wide and globally oriented entertainment industry. Placing women’s voices in social and historical contexts, the authors critically analyze salient discourses, representations, meanings, and politics of “voice” in Asian popular music of the 20th century to the present day.

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