scholarly journals Growth Hormone Releasing Peptide-2 Attenuation of Protein Kinase C-Induced Inflammation in Human Ovarian Granulosa Cells

2016 ◽  
Vol 17 (8) ◽  
pp. 1359
Author(s):  
Yi-Ning Chao ◽  
David Sun ◽  
Yen-Chun Peng ◽  
Yuh-Lin Wu
Keyword(s):  
Growth Hormone ◽  
Protein Kinase C ◽  
Protein Kinase ◽  
Granulosa Cells ◽  
Ovarian Granulosa Cells ◽  
Kinase C

Sites of inhibition of steroidogenesis by activation of protein kinase-C in swine ovarian (granulosa) cells.

Endocrinology ◽  
1993 ◽  
Vol 132 (5) ◽  
pp. 1983-1990 ◽  
Author(s):  
J A Flores ◽  
J C Garmey ◽  
J E Nestler ◽  
J D Veldhuis
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Granulosa Cells ◽  
Ovarian Granulosa Cells ◽  
Kinase C

scholarly journals Pituitary adenylate cyclase activating polypeptide as a novel hypophysiotropic factor in fish

2000 ◽  
Vol 78 (3) ◽  
pp. 329-343 ◽  
Author(s):  
Anderson OL Wong ◽  
Wen Sheng Li ◽  
Eric KY Lee ◽  
Mei Yee Leung ◽  
Lai Yin Tse ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Protein Kinase C ◽  
Protein Kinase ◽  
Adenylate Cyclase ◽  
Protein Kinase A ◽  
Anterior Pituitary ◽  
Kinase C ◽  
Pituitary Adenylate Cyclase ◽  
Pacap Receptors ◽  
Kinase A

Pituitary adenylate cyclase activating polypeptide (PACAP) is a novel member of the secretin-glucagon peptide family. In mammals, this peptide has been located in a wide range of tissues and is involved in a variety of biological functions. In lower vertebrates, especially fish, increasing evidence suggests that PACAP may function as a hypophysiotropic factor regulating pituitary hormone secretion. PACAP has been identified in the brain-pituitary axis of representative fish species. The molecular structure of fish PACAP is highly homologous to mammalian PACAP. The prepro-PACAP in fish, however, is distinct from that of mammals as it also contains the sequence of fish GHRH. In teleosts, the anterior pituitary is under direct innervation of the hypothalamus and PACAP nerve fibers have been identified in the pars distalis. Using the goldfish as a fish model, mRNA transcripts of PACAP receptors, namely the PAC1 and VPAC1 receptors, have been identified in the pituitary as well as in various brain areas. Consistent with the pituitary expression of PACAP receptors, PACAP analogs are effective in stimulating growth hormone (GH) and gonadotropin (GTH)-II secretion in the goldfish both in vivo and in vitro. The GH-releasing action of PACAP is mediated via pituitary PAC1 receptors coupled to the adenylate cyclase-cAMP-protein kinase A and phospholipase C-IP3-protein kinase C pathways. Subsequent stimulation of Ca2+ entry through voltage-sensitive Ca2+ channels followed by activation of Ca2+-calmodulin protein kinase II is likely the downstream mechanism mediating PACAP-stimulated GH release in goldfish. Although the PACAP receptor subtype(s) and the associated post-receptor signaling events responsible for PACAP-stimulated GTH-II release have not been characterized in goldfish, these findings support the hypothesis that PACAP is produced in the hypothalamus and delivered to the anterior pituitary to regulate GH and GTH-II release in fish.Key words: PACAP, VIP, PAC1 receptor, VPAC1 receptor, VPAC2 receptor, growth hormone, gonadotropin-II, cAMP, protein kinase A, protein kinase C, calcium, pituitary cells, goldfish, and teleost.

Protein kinase C: A new linkage marker for growth hormone and for COL1A1

Genomics ◽  
1989 ◽  
Vol 5 (1) ◽  
pp. 163-165 ◽  
Author(s):  
M.L. Summar ◽  
J.A. Phillips ◽  
M.R.S. Krishnamani ◽  
J. Keefer ◽  
J. Trofatter ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Protein Kinase C ◽  
Protein Kinase ◽  
Kinase C ◽  
Linkage Marker

Mechanism of action of growth hormone in adipocytes: a role for protein kinase C?

1993 ◽  
Vol 21 (4) ◽  
pp. 376S-376S
Author(s):  
RICHARD G. VERNON ◽  
SYLVIA LINDSAY-WATT ◽  
ERIC FINLEY
Keyword(s):  
Growth Hormone ◽  
Protein Kinase C ◽  
Protein Kinase ◽  
Mechanism Of Action ◽  
Kinase C

scholarly journals Protein Kinase C (PKC)-Mediated Growth Hormone (GH) Actions

1998 ◽  
Vol 45 (Suppl) ◽  
pp. S97-S99 ◽  
Author(s):  
KAE WAKAI ◽  
TOSHIO TSUSHIMA ◽  
HITOMI MURAKAMI ◽  
OSAMU ISOZAKI ◽  
HIROSHI DEMURA ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Protein Kinase C ◽  
Protein Kinase ◽  
Kinase C

scholarly journals Growth hormone activates mitogen-activated protein kinase and S6 kinase and promotes intracellular tyrosine phosphorylation in 3T3-F442A preadipocytes

1992 ◽  
Vol 284 (3) ◽  
pp. 649-652 ◽  
Author(s):  
N G Anderson
Keyword(s):  
Growth Hormone ◽  
Protein Kinase C ◽  
Protein Kinase ◽  
Tyrosine Phosphorylation ◽  
Phorbol Esters ◽  
Mitogen Activated Protein Kinase ◽  
S6 Kinase ◽  
Kinase C ◽  
Transient Activation ◽  
Mitogen Activated Protein

Physiological concentrations of growth hormone induced a rapid and transient activation of mitogen-activated protein kinase (MAP kinase) and S6 kinase in 3T3-F442A preadipocytes. These effects were abrogated by staurosporine and in cells chronically pretreated with phorbol esters, suggesting that protein kinase C is involved in the mechanism of activation. In addition, three cytosolic proteins exhibited a growth-hormone-dependent increase in tyrosine phosphorylation.

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