The Winding Roadmap of Biomarkers toward Clinic: Lessons from Predictors of Resistance to Anti-EGFRs in Metastatic Colorectal Cancer
2018 ◽
Vol 19
(8)
◽
pp. 2298
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Keyword(s):
In the evolving molecular landscape of metastatic colorectal cancer, optimizing available tools to select patients to receive anti-epidermal growth factor receptor (anti-EGFR) monoclonal antibodies is a modern challenge of colorectal oncologists. Several molecular biomarkers have been investigated in recent years as potential predictors of resistance to anti-EGFR agents in preclinical and clinical retrospective series. Nevertheless, none of them have been implemented in clinical practice due to the lack of a formal prospective demonstration. Here, we propose a literature review of molecular alterations associated with resistance to anti-EGFRs, underlining the reasons why their roadmap from laboratories to clinics was prematurely halted.
2008 ◽
Vol 28
(11 Part 2)
◽
pp. 31S-41S
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2008 ◽
Vol 28
(6)
◽
pp. 742-754
◽
2013 ◽
Vol 14
(8)
◽
pp. 409-416
◽