scholarly journals Glomerular Filtration Rate Estimation by a Novel Numerical Binning-Less Isotonic Statistical Bivariate Numerical Modeling Method

Information ◽  
2019 ◽  
Vol 10 (3) ◽  
pp. 100 ◽  
Author(s):  
Sebastian Giles ◽  
Simone Fiori
Keyword(s):  
Numerical Modeling ◽  
Glomerular Filtration Rate ◽  
Glomerular Filtration ◽  
Filtration Rate ◽  
Empirical Relationship ◽  
Numerical Algorithms ◽  
Creatinine Concentration ◽  
Estimate Glomerular Filtration Rate ◽  
Glomerular Filtration Rate Estimation ◽  
Progression Of Renal Disease

Statistical bivariate numerical modeling is a method to infer an empirical relationship between unpaired sets of data based on statistical distributions matching. In the present paper, a novel efficient numerical algorithm is proposed to perform bivariate numerical modeling. The algorithm is then applied to correlate glomerular filtration rate to serum creatinine concentration. Glomerular filtration rate is adopted in clinical nephrology as an indicator of kidney function and is relevant for assessing progression of renal disease. As direct measurement of glomerular filtration rate is highly impractical, there is considerable interest in developing numerical algorithms to estimate glomerular filtration rate from parameters which are easier to obtain, such as demographic and `bedside’ assays data.

The influence of a cooked-fish meal on estimated glomerular filtration rate

2020 ◽  
Vol 57 (2) ◽  
pp. 182-185
Author(s):  
Kezah F Shah ◽  
Paul E Stevens ◽  
Edmund J Lamb
Keyword(s):  
Glomerular Filtration Rate ◽  
Glomerular Filtration ◽  
Cystatin C ◽  
Fish Consumption ◽  
Filtration Rate ◽  
Estimated Glomerular Filtration Rate ◽  
Fish Muscle ◽  
Creatinine Concentration ◽  
Glomerular Filtration Rate Estimation ◽  
Blood Creatinine

Background Ingestion of cooked meat increases circulating blood creatinine concentration due to conversion of creatine during cooking. This may cause falsely low estimated glomerular filtration rate. National Institute for Health and Care Excellence chronic kidney disease guidelines recommend meat avoidance prior to blood testing for estimated glomerular filtration rate. Fish muscle also contains creatine, but the influence of fish consumption on blood creatinine concentration has not been studied. Method Four blood samples were collected from each of 20 healthy volunteers: one before and three (at 2, 4 and 20 h) after consuming cooked fish (200 g/person cod, approximately 35 g/person protein). Apart from this meal, for the study duration, subjects were asked to avoid eating meat or fish. Creatinine and cystatin C were measured and estimated glomerular filtration rate (CKD-EPI equations) was calculated. Results Serum creatinine concentration (mean) was increased relative to the preprandial concentration (71.8 μmol/L) in all subjects at 2 h (77.3 μmol/L) and in 17/20 subjects at 4 h (75.5 μmol/L) ( P < 0.0001) but was not significantly different from baseline after 20 h (73.6 μmol/L P = 0.1170). Mean cystatin C concentration remained unchanged throughout the study ( P > 0.05). Estimated glomerular filtration rate calculated using the CKD-EPI (creatinine) and CKD-EPI (creatinine and cystatin C) equations demonstrated significant declines at 2 and 4 h ( P < 0.0005), while the CKD-EPI (cystatin C) equation remained unchanged ( P > 0.05). Conclusion Cooked fish consumption transiently increases blood creatinine concentration and consequently lowers the estimates of glomerular filtration rate derived from creatinine-based equations. Consideration should be given to avoidance of cooked fish consumption before glomerular filtration rate estimation.

Features of glomerular filtration rate evaluation for kidney function assessment in patients with rheumatoid arthritis

2020 ◽  
pp. 44-48
Author(s):  
V. A. Aleksandrov ◽  
L. N. Shilova ◽  
A. V. Aleksandrov
Keyword(s):  
Rheumatoid Arthritis ◽  
Glomerular Filtration Rate ◽  
Glomerular Filtration ◽  
Cystatin C ◽  
Filtration Rate ◽  
Clinical Decision Making ◽  
Clinical Decision ◽  
Initial Assessment ◽  
Serum Cystatin C ◽  
Creatinine Concentration

The development of renal dysfunction in patients with rheumatoid arthritis (RA) is due to the presence and severity of autoimmune disorders, chronic systemic inflammation, a multiplicity of comorbid conditions, and pharmacotherapy features. The most important parameter that describes the general condition of the kidneys is glomerular filtration rate (GFR). This review presents the data on the possibilities of modern methods for determining estimated GFR (e-GFR) and the specificity of their use in various clinical situations that accompany the course of RA. For the initial assessment of GFR in patients with RA it is advisable to use the measurement of e-GFR based on serum creatinine concentration using the CKD-EPI equation (2009) (with or without indexing by body surface area). In cases where the e-GFR equations are not reliable enough or the results of this test are insufficient for clinical decision making, the serum cystatin C level should be measured and the combined GFR calculation based on creatinine and cystatin C should be used.

scholarly journals Incidence and Risk Factors of Hyperuricemia among 2.5 Million Chinese Adults during the Years 2017–2018

2021 ◽  
Vol 18 (5) ◽  
pp. 2360
Author(s):  
Ruiqi Shan ◽  
Yi Ning ◽  
Yuan Ma ◽  
Xiang Gao ◽  
Zechen Zhou ◽  
...  
Keyword(s):  
Risk Factors ◽  
Glomerular Filtration Rate ◽  
Glomerular Filtration ◽  
Population Size ◽  
Incidence Rate ◽  
Urban Population ◽  
Filtration Rate ◽  
Chinese Adults ◽  
Estimate Glomerular Filtration Rate ◽  
Fat Liver

Objective: To assess the incidence and risk factors of hyperuricemia among Chinese adults in 2017–2018. Methods: A total of 2,015,847 adults (mean age 41.2 ± 12.7, 53.1% men) with serum uric acid concentrations assayed on at least two separate days in routine health examinations during 2017–2018 were analyzed. Hyperuricemia was defined as fasting serum urate concentration >420 μmol/L in men and >360 μmol/L in women. The overall and sex-specific incidence rate were stratified according to age, urban population size, geographical region, annual average temperature and certain diseases. Logistic regression analyses were performed to explore risk factors associated with hyperuricemia. Results: 225,240 adults were newly diagnosed with hyperuricemia. The age- and sex-standardized incidence rate per 100 person-years was 11.1 (95%CI: 11.0–11.1) (15.2 for men and 6.80 for women). The risk of hyperuricemia was positively associated with younger age, being male, larger urban population size, higher annual temperature, higher body mass index, lower estimate glomerular filtration rate, hypertension, dyslipidemia and fat liver. Conclusions: The incidence of hyperuricemia was substantial and exhibited a rising trend among younger adults, especially among men. Socioeconomic and geographic variation in incidence were observed. The risk of hyperuricemia was associated with estimate glomerular filtration rate, fat liver and metabolic factors.

scholarly journals The Impact of Interlaboratory Differences in Cystatin C Assay Measurement on Glomerular Filtration Rate Estimation

2011 ◽  
Vol 6 (9) ◽  
pp. 2150-2156 ◽  
Author(s):  
Christine A. White ◽  
Andrew D. Rule ◽  
Christine P. Collier ◽  
Ayub Akbari ◽  
John C. Lieske ◽  
...  
Keyword(s):  
Glomerular Filtration Rate ◽  
Glomerular Filtration ◽  
Cystatin C ◽  
Filtration Rate ◽  
Rate Estimation ◽  
Glomerular Filtration Rate Estimation ◽  
The Impact
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