scholarly journals Stage 2 Acupuncture for Poor Ovarian Response: A Randomized Controlled Trial

2021 ◽  
Vol 10 (10) ◽  
pp. 2182
Author(s):  
Jihyun Kim ◽  
Hoyoung Lee ◽  
Tae-Young Choi ◽  
Joong Il Kim ◽  
Byoung-Kab Kang ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Controlled Trial ◽  
Ovarian Response ◽  
Controlled Ovarian Hyperstimulation ◽  
University Hospital ◽  
Ovarian Hyperstimulation ◽  
Poor Ovarian Response ◽  
Vitro Fertilization ◽  
Randomized Controlled

Acupuncture is believed to improve ovarian reserve and reproductive outcomes in women undergoing in vitro fertilization (IVF). This study was conducted to evaluate the effect of network-optimized acupuncture followed by IVF on the oocyte yield in women showing a poor ovarian response. This study was an exploratory randomized controlled trial conducted from June 2017 to January 2020 at the Pusan National University Hospital. Women diagnosed with poor ovarian response were enrolled and randomly divided into two groups: IVF alone and Ac + IVF groups (16 acupuncture sessions before IVF treatment). Eight acupoints with high degree centrality and betweenness centrality were selected using network analysis. Among the participants, compared with the IVF treatment alone, the acupuncture + IVF treatment significantly increased the number of retrieved mature oocytes in women aged more than 37 years and in those undergoing more than one controlled ovarian hyperstimulation cycle. The negative correlation between the number of retrieved mature oocytes and consecutive controlled ovarian hyperstimulation cycles was not observed in the Ac + IVF group irrespective of the maternal age. These findings suggest that physicians can consider acupuncture for the treatment of women with poor ovarian response and aged > 37 years or undergoing multiple IVF cycles.

scholarly journals Effect of acupuncture on women with poor ovarian response: study protocol for a multicenter randomized controlled trial

2019 ◽  
Author(s):  
yigong Fang ◽  
huanfang Xu ◽  
chensi Zheng ◽  
liyun He ◽  
tongsheng Su ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Ovarian Reserve ◽  
Controlled Trial ◽  
Ovarian Response ◽  
Poor Ovarian Response ◽  
Cleavage Rate ◽  
Vitro Fertilization ◽  
Randomized Controlled ◽  
Multicenter Randomized Controlled Trial

Abstract Background: Poor ovarian response (POR), a manifestation of low ovarian reserve and ovarian aging , leads to a significantly reduced pregnancy rate after in vitro fertilization-embryo transfer (IVF-ET) . Acupuncture is effective at improving ovarian reserve. The purpose of this study is to evaluate the effect of acupuncture on increasing the number of retrieved oocytes after controlled ovarian hyperstimulation (COH) in women with POR. Methods: This is a multicenter randomized controlled trial . A total of 140 women with POR will be randomly assigned to receive acupuncture or non-treatment for 12 weeks before COH. The primary outcome will be the number of retrieved oocytes. The secondary outcomes include antral follicle count (AFC), serum level of anti-müllerian hormone (AMH), basal serum levels of follicle stimulating hormone (FSH), luteinizing hormone (LH) and estradiol (E2) , the score of the self-rating anxiety scale (SAS), the fertilization rate, the cleavage rate, the available embryo rate and the high-quality embryo rate. The safety of acupuncture will also be assessed. Discussion: The results of this trial will identify the effectiveness of acupuncture in the treatment of POR. This will provide a new treatment option for POR patients and physicians.

scholarly journals Effect of acupuncture on women with poor ovarian response: study protocol for a multicenter randomized controlled trial

2020 ◽  
Author(s):  
yigong Fang ◽  
huanfang Xu ◽  
chensi Zheng ◽  
liyun He ◽  
tongsheng Su ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Ovarian Reserve ◽  
Controlled Trial ◽  
Ovarian Response ◽  
Controlled Ovarian Hyperstimulation ◽  
Ovarian Hyperstimulation ◽  
Poor Ovarian Response ◽  
Cleavage Rate ◽  
Randomized Controlled ◽  
Multicenter Randomized Controlled Trial

Abstract Background: Poor ovarian response (POR), a manifestation of low ovarian reserve and ovarian aging, leads to a significantly reduced pregnancy rate after in vitro fertilization-embryo transfer. Acupuncture has been increasingly used for improving ovarian reserve. The purpose of this study is to evaluate the effect of acupuncture on increasing the number of retrieved oocytes after controlled ovarian hyperstimulation in women with POR.Methods: This is a multicenter randomized controlled trial. A total of 140 women with POR will be randomly assigned to receive acupuncture or non-treatment for 12 weeks before controlled ovarian hyperstimulation. The primary outcome will be the number of retrieved oocytes. The secondary outcomes include antral follicle count , serum level of anti-müllerian hormone, basal serum levels of follicle stimulating hormone, luteinizing hormone and estradiol, the score of the self-rating anxiety scale, the fertilization rate, the cleavage rate, the available embryo rate and the high-quality embryo rate. The safety of acupuncture will also be assessed.Discussion: The results of this trial will help to identify the effectiveness of acupuncture in the treatment of POR. This may provide a new treatment option for POR patients and their physicians.Trial registration: AMCTR-IPR-18000198. Registered on 10 August 2018, http://www.acmctr.org/showproj.aspx?proj=289

scholarly journals Effect of acupuncture on women with poor ovarian response: a study protocol for a multicenter randomized controlled trial

Trials ◽  
2020 ◽  
Vol 21 (1) ◽  
Author(s):  
Huanfang Xu ◽  
Chensi Zheng ◽  
Liyun He ◽  
Tongsheng Su ◽  
Huidan Wang ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Ovarian Reserve ◽  
Controlled Trial ◽  
Ovarian Response ◽  
Serum Levels ◽  
Controlled Ovarian Hyperstimulation ◽  
Ovarian Hyperstimulation ◽  
Poor Ovarian Response ◽  
Randomized Controlled ◽  
Multicenter Randomized Controlled Trial

Abstract Background Poor ovarian response (POR), a manifestation of low ovarian reserve and ovarian aging, leads to a significant reduction in the pregnancy rate after in vitro fertilization-embryo transfer. Acupuncture has increasingly been used to improve the ovarian reserve. The purpose of this study will be to evaluate the effect of acupuncture on increasing the number of retrieved oocytes after controlled ovarian hyperstimulation in women with POR. Methods This will be a multicenter randomized controlled trial. A total of 140 women with POR will be randomly assigned to receive acupuncture or nontreatment for 12 weeks before controlled ovarian hyperstimulation. The primary outcome will be the number of retrieved oocytes. The secondary outcomes will be antral follicle counts, serum levels of anti-Müllerian hormone, basal serum levels of follicle stimulating hormone, luteinizing hormone and estradiol levels, scores from the self-rating anxiety scale, fertilization rates, cleavage rates, available embryo rates, and high-quality embryo rates. The safety of acupuncture will also be assessed. Discussion The results of this trial will help to determine the effectiveness of acupuncture in the treatment of POR. This may provide a new treatment option for patients with POR and their physicians. Trial registration AMCTR-IPR-18000198. Registered on 10 August 2018.

scholarly journals Effect of acupuncture on women with poor ovarian response: study protocol for a multicenter randomized controlled trial

2020 ◽  
Author(s):  
yigong Fang ◽  
huanfang Xu ◽  
chensi Zheng ◽  
liyun He ◽  
tongsheng Su ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Ovarian Reserve ◽  
Controlled Trial ◽  
Ovarian Response ◽  
Serum Levels ◽  
Controlled Ovarian Hyperstimulation ◽  
Ovarian Hyperstimulation ◽  
Poor Ovarian Response ◽  
Randomized Controlled ◽  
Multicenter Randomized Controlled Trial

Abstract Background: Poor ovarian response (POR), a manifestation of low ovarian reserve and ovarian aging, leads to a significant reduction in the pregnancy rate after in vitro fertilization-embryo transfer. Acupuncture has increasingly been used to improve the ovarian reserve. The purpose of this study will be to evaluate the effect of acupuncture on increasing the number of retrieved oocytes after controlled ovarian hyperstimulation in women with POR.Methods: This will be a multicenter randomized controlled trial. A total of 140 women with POR will be randomly assigned to receive acupuncture or nontreatment for 12 weeks before controlled ovarian hyperstimulation. The primary outcome will be the number of retrieved oocytes. The secondary outcomes will be antral follicle counts, serum levels of anti-Müllerian hormone, basal serum levels of follicle stimulating hormone, luteinizing hormone and estradiol levels, scores from the self-rating anxiety scale, fertilization rates, cleavage rates, available embryo rates and high-quality embryo rates. The safety of acupuncture will also be assessed.Discussion: The results of this trial will help to determine the effectiveness of acupuncture in the treatment of POR. This may provide a new treatment option for patients with POR and their physicians.Trial registration: AMCTR-IPR-18000198. Registered on 10 August 2018, http://www.acmctr.org/showproj.aspx?proj=289

scholarly journals Fixed Versus Flexible Antagonist Protocol in Women with Predicted High Ovarian Response except PCOS : A Randomized Controlled Trial

2020 ◽  
Author(s):  
Xiu Luo ◽  
Li Pei ◽  
Fujie Li ◽  
Chunli Li ◽  
Guoning Huang ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Treatment Duration ◽  
Gnrh Antagonist ◽  
Controlled Trial ◽  
Ovarian Response ◽  
Gnrh Antagonists ◽  
Vitro Fertilization ◽  
Randomized Controlled ◽  
Significant Difference

Abstract Background: No previous study directly compares the fixed day-5 initiation versus the flexible initiation of GnRH antagonist administration in IVF/ICSI for those patients who are predicted as high ovarian responders without PCOS. To evaluate whether the number of oocytes retrieved is different by using the two GnRH antagonist protocols in Chinese women with predicted high ovarian response except PCOS.Methods: A randomized controlled trial of 201 infertile women with predicted high ovarian response except PCOS undergoing in vitro fertilization. Ovary stimulation was performed using recombinant FSH and GnRH antagonists. GnRH antagonist ganirelix (0.25 mg/d) was started either on day 5 of stimulation (fixed group) or when LH was >10 IU/L, and/or a follicle with mean diameter >12 mm was present, and/or serum E2 was >300pg/ml. Patient monitoring was initiated on day 3 of stimulation in flexible group.Result(s): No significant difference was observed between the fixed and flexible groups regarding the number of oocyte retrieved(16.72±7.25 vs. 17.47±5.88, P=0.421), the Gonadotropin treatment duration(9.53±1.07 vs. 9.67±1.03, P=0.346)and total Gonadotropin dose(1427.75±210.6 vs. 1455.94±243.44, P=0.381). GnRH antagonist treatment duration in fixed protocol was statistically longer than the flexible protocol (6.57±1.17 vs 6.04±1.03, P=0.001). There was no premature LH surge in either protocol. Conclusion(s): Fixed GnRH antagonist administration on day 5 of stimulation appear to achieve a comparable oocyte retrieved compared with flexible antagonist administration.Trial registration: NCT02635607 posted on December 16, 2015 in clinicaltrials.gov.

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