scholarly journals AIDS Related Kaposi’s Sarcoma: A 20-Year Experience in a Clinic from the South-East of Romania

2021 ◽  
Vol 10 (22) ◽  
pp. 5346
Author(s):  
Manuela Arbune ◽  
Monica-Daniela Padurariu-Covit ◽  
Laura-Florentina Rebegea ◽  
Gabriela Lupasteanu ◽  
Anca-Adriana Arbune ◽  
...  
Keyword(s):  
Kaposi's Sarcoma ◽  
Early Recognition ◽  
Kaposi’S Sarcoma ◽  
Close Monitoring ◽  
Antiretroviral Adherence ◽  
Medical Progress ◽  
Aids Epidemic ◽  
Acquired Immunodeficiency ◽  
Immunodeficiency Syndrome

Kaposi’s sarcoma (KS) was peculiarly described in the first notified cases of the acquired immunodeficiency syndrome as an opportunistic condition. However, the medical progress and the development of active antiretroviral therapy allowed the control of the HIV/AIDS epidemic, although the features of KS have changed throughout the past decades. The purpose of our study is to assess the epidemiological and clinical features of AIDS related KS in Romanian patients. A retrospective follow-up study was achieved in a single infectious diseases’ clinic from Galati—Romania, between 2001 and 2021. Referring to 290 new HIV diagnosed cases from our clinic retained in care, the prevalence of KS was 3.4%. The main characteristics of patients with KS are a median age of 33, a predominance of males, prevalent severe systemic forms of diseases, frequent association of past or concomitant tuberculosis, and context of immune reconstruction syndrome. The mortality rate was 70%. KS has occurred in patients with delayed HIV diagnoses and inadequate adherence to therapy. Early recognition of both infections, the close monitoring of latent or symptomatic tuberculosis, improving the antiretroviral adherence and raising the access to oncologic procedures in Romanian HIV patients could improve their prognosis related to KS.

Kaposi's Sarcoma of the Larynx

1997 ◽  
Vol 106 (7) ◽  
pp. 563-567 ◽  
Author(s):  
Neil F. Schiff ◽  
Peak Woo ◽  
Donald J. Annino ◽  
Stanley M. Shapshay
Keyword(s):  
Carbon Dioxide Laser ◽  
Kaposi's Sarcoma ◽  
Kaposi’S Sarcoma ◽  
Vascular Disorder ◽  
Voice Change ◽  
Aids Epidemic ◽  
Number Of Patients ◽  
Acquired Immunodeficiency ◽  
Immunodeficiency Syndrome ◽  
Supraglottic Larynx

Kaposi's sarcoma (KS) is a neoplastic vascular disorder, classically arising in the skin of the lower extremities. As a consequence of the acquired immunodeficiency syndrome (AIDS) epidemic, an increasing number of patients have been found to have KS. In AIDS patients, KS appears to exhibit a more diffuse nature and frequently affects the head and neck. Mucosal lesions are most often seen, commonly involving the oral cavity. Only rare cases of laryngeal involvement have been recorded in the literature. We report 2 cases of KS of the supraglottic larynx. Our first patient, an elderly man of Mediterranean descent, complained of voice change and throat discomfort. Endoscopy with biopsy for diagnosis allowed conservative treatment with chemotherapy. Our second patient was a younger man with AIDS who presented with symptoms of airway obstruction. Management with carbon dioxide laser epiglottectomy was successful in relieving that patient's symptoms. Although rare, KS may present in both healthy and immunocompromised patients, and must be considered in the differential diagnosis of all violaceous lesions of the larynx.

Multicentric Kaposi's Sarcoma of the Conjunctiva in a Male Homosexual with the Acquired Immunodeficiency Syndrome

Ophthalmology ◽  
1983 ◽  
Vol 90 (8) ◽  
pp. 879-884 ◽  
Author(s):  
Abe M. Macher ◽  
Alan Palestine ◽  
Henry Masur ◽  
Gail Bryant ◽  
Chi-Chao Chan ◽  
...  
Keyword(s):  
Acquired Immunodeficiency Syndrome ◽  
Kaposi's Sarcoma ◽  
Kaposi’S Sarcoma ◽  
Male Homosexual ◽  
Acquired Immunodeficiency ◽  
Immunodeficiency Syndrome

Kaposi's sarcoma and the acquired immunodeficiency syndrome: treatment with high and low doses of recombinant leukocyte A interferon.

1986 ◽  
Vol 4 (4) ◽  
pp. 544-551 ◽  
Author(s):  
F X Real ◽  
H F Oettgen ◽  
S E Krown
Keyword(s):  
Acquired Immunodeficiency Syndrome ◽  
Kaposi's Sarcoma ◽  
Opportunistic Infections ◽  
Kaposi’S Sarcoma ◽  
Response Duration ◽  
High Dose ◽  
Median Response ◽  
Major Response ◽  
Acquired Immunodeficiency ◽  
Immunodeficiency Syndrome

The efficacy of recombinant leukocyte A interferon (rIFN-alpha A [Roferon-A, Hoffman-La Roche, Nutley, NJ]) treatment of Kaposi's sarcoma in patients with acquired immunodeficiency syndrome was evaluated in sequential trials using high doses (36 X 10(6) units) and low doses (3 X 10(6) units) of interferon. A major response was seen in 38% of patients treated at the high dose, with a median response duration of 18 months. At the low dose, the major response rate was 3%; dose escalation to 36 X 10(6) units resulted in an additional major response rate of 17% in low-dose nonresponders, with a median response duration of 10 months. Four of 11 patients who achieved a complete response remain free of disease, whereas all partial responders have shown disease progression. Unacceptable toxicity occurred in 27% of patients initially treated at the high dose and only in 10% of those who had progressive dose escalation up to 36 X 10(6) units. Prior opportunistic infections correlated negatively with therapeutic response, whereas large tumor burden and gastrointestinal involvement did not. Responding patients showed a significantly longer survival and a lower incidence of subsequent opportunistic infections than nonresponders. However, from our study we cannot determine whether rIFN-alpha A has an effect on the natural history of Kaposi's sarcoma in patients with the acquired immunodeficiency syndrome.

Primary Classic Kaposi's Sarcoma Limited to the Glans Penis (Not Associated with Acquired Immunodeficiency Syndrome)

1992 ◽  
Vol 59 (6) ◽  
pp. 80-83
Author(s):  
M. Guy ◽  
D. Singer ◽  
Y. Arieli ◽  
S. Eisenkfraft
Keyword(s):  
Drug Abuse ◽  
Blood Transfusion ◽  
Acquired Immunodeficiency Syndrome ◽  
Kaposi's Sarcoma ◽  
Kaposi’S Sarcoma ◽  
Glans Penis ◽  
Adequate Therapy ◽  
Acquired Immunodeficiency ◽  
One Year ◽  
Immunodeficiency Syndrome

We report two cases of primary Kaposi's sarcoma limited to the glans penis. In circumcised men the basic lesion appears as a reddish-violet nodule. The patients denied homosexuality, drug abuse or blood transfusion. Excision of the lesion with wide margins and radiotherapy was adequate therapy. Serological investigations for HIV were all negative. At two years and one year after operation the patients are well with normal serology.

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