scholarly journals Correlation of Pancreatic T1 Values Using Modified Look-Locker Inversion Recovery Sequence (MOLLI) with Pancreatic Exocrine and Endocrine Function

2020 ◽  
Vol 9 (6) ◽  
pp. 1805
Author(s):  
Norihiro Ashihara ◽  
Takayuki Watanabe ◽  
Satoko Kako ◽  
Yasuhiro Kuraishi ◽  
Makiko Ozawa ◽  
...  

Quantifying myocardial T1 values has been useful for detecting and characterizing fibrotic appearance in myocardial infarction, focal scars, and non-ischemic cardiomyopathies. Since pancreatic exocrine function decreases with chronic pancreatic fibrosis advancement, this study examined the correlation between pancreatic T1 values and pancreatic exocrine and endocrine insufficiency. Methods: Thirty-two patients underwent abdominal contrast-enhanced MRI in our department between October 2017 and February 2019. We evaluated the T1 values of the pancreas using a modified Look-Locker inversion recovery sequence (MOLLI), pancreatic exocrine insufficiency (PEI) by fecal elastase 1 (FE1) values, and pancreatic endocrine insufficiency using fasting insulin and blood glucose levels to calculate the HOMA-β. This trial is registered in the UMIN Clinical Trials Registry as UMIN 000030067. Results: The median cohort (9 males and 23 females) age was 71 (range: 49–84) years. Eighteen patients had pancreatic cysts, three had alcohol-induced chronic pancreatitis, three had pancreatic cancer, and eight possessed other pancreatic features (two patients each with autoimmune pancreatitis, acute pancreatitis, or a bile duct tumor, one with idiopathic chronic pancreatitis, and one healthy control with negative findings). The median pancreatic T1 value measured by the MOLLI was 857.5 ms (597–2569). A significant negative correlation was found between the T1 mapping and FE1 values (r = 0.69, p < 0.01), with none for the T1 with HOMA-β or serum albumin, triglycerides, or body mass index. Conclusions: the pancreatic T1 values correlated significantly with pancreatic exocrine function and might be useful in PEI diagnosis.

Pancreas ◽  
1987 ◽  
Vol 2 (2) ◽  
pp. 222-229 ◽  
Author(s):  
Luigi Bolondi ◽  
Patrizia Priori ◽  
Lucio Gullo ◽  
Vittorio Santi ◽  
Silvia Li Bassi ◽  
...  

Pancreas ◽  
1996 ◽  
Vol 13 (1) ◽  
pp. 71-79 ◽  
Author(s):  
Masanori Sugiyama ◽  
Oichiro Kobori ◽  
Yutaka Atomi ◽  
Nobuaki Wada ◽  
Akira Kuroda ◽  
...  

2008 ◽  
Vol 42 (8) ◽  
pp. 950-955 ◽  
Author(s):  
Samer Alkaade ◽  
Numan Cem Balci ◽  
Amir Javad Momtahen ◽  
Frank Burton

Diabetologia ◽  
1979 ◽  
Vol 16 (6) ◽  
pp. 355-358 ◽  
Author(s):  
W. J. Kalk ◽  
A. I. Vinik ◽  
W. P. U. Jackson ◽  
S. Bank

1996 ◽  
Vol 20 (3) ◽  
pp. 191-196 ◽  
Author(s):  
Masanori Sugiyama ◽  
Oichiro Kobori ◽  
Yutaka Atomi ◽  
Nobuaki Wada ◽  
Akira Kuroda ◽  
...  

Radiology ◽  
2000 ◽  
Vol 215 (2) ◽  
pp. 358-364 ◽  
Author(s):  
Olivier Cappeliez ◽  
Myriam Delhaye ◽  
Jacques Devière ◽  
Olivier Le Moine ◽  
Thierry Metens ◽  
...  

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