scholarly journals High Endothelial Venule with Concomitant High CD8+ Tumor-Infiltrating Lymphocytes Is Associated with a Favorable Prognosis in Resected Gastric Cancer

2020 ◽  
Vol 9 (8) ◽  
pp. 2628
Author(s):  
Soon Auck Hong ◽  
Hye Won Hwang ◽  
Min Kyoon Kim ◽  
Tae Jin Lee ◽  
Kwangil Yim ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Antitumor Immunity ◽  
Tumor Infiltrating Lymphocytes ◽  
Nodal Metastasis ◽  
High Endothelial Venule ◽  
Prognostic Role ◽  
High Endothelial Venules ◽  
Favorable Prognosis ◽  
Infiltrating Lymphocytes ◽  
Resected Gastric Cancer

CD8+ tumor-infiltrating lymphocytes (TILs) play a major role in antitumor immunity. High endothelial venules (HEVs) are related to diverse immune cells in solid tumors. We analyzed CD8+ and Foxp3+ TILs in combination with HEVs to determine their prognostic role in advanced gastric cancer (AGC). We enrolled 157 patients with AGC in this study. The densities of CD8+ TILs and Foxp3+ TILs were calculated using immunohistochemical staining. HEVs were evaluated by MECA-79 expression. HEVs were identified in 60 (38.2%) cases and was significantly associated with an increased number of CD8+ TILs (p = 0.027) but not of Foxp3+ TILs (p = 0.455) and CD20+ TILs (p = 0.163). A high CD8+/HEV+ level was significantly associated with nodal metastasis (p = 0.048). In survival analysis, patients with high CD8+/HEV+ levels demonstrated the longest overall survival (OS) (p = 0.015). Furthermore, a high CD8+/HEV+ level was an independent prognostic factor in AGC (p = 0.011; hazard ratio (HR) = 0.435; 95% confidence interval (CI) = 0.245–0.837). HEVs were found to play an important role in antitumor immunity associated with CD8+ TILs in AGC. This analysis of HEVs and CD8+ TILs helps stratify patients with AGC and sheds light on tumor immunity.

scholarly journals The relationship of the tertiary lymphoid structures with the tumor-infiltrating lymphocytes and its prognostic value in gastric cancer

2021 ◽  
Author(s):  
Nana Zhang ◽  
Guanjun Zhang ◽  
Depu Wang ◽  
Hao Liu ◽  
Yuchi Zhang ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
T Cells ◽  
Prognostic Value ◽  
Tumor Infiltrating Lymphocytes ◽  
High Endothelial Venules ◽  
Tumor Center ◽  
Tertiary Lymphoid Structures ◽  
Lymphoid Structures ◽  
Infiltrating Lymphocytes ◽  
The Relationship

IntroductionTo explore the relationship between the tertiary lymphoid structures (TLSs) and tumor-infiltrating lymphocytes (TILs), and their distribution characteristics as well as the prognostic value in gastric cancer (GC).Material and methodsThe TLSs and four subtypes of TILs were assessed by immunohistochemistry (IHC) staining. The presence of MECA-79 positive high endothelial venules (HEVs) identified among the ectopic lymphocyte aggregation area in the GC tissue was defined as a valid TLSs.The number of labeled TILs were observed in 5 fields of the most positive cells in tumor center, invasive edge and within the TLSs, respectively, at a field of vision×40.ResultsThe TLSs distributed significantly higher in the tumor invasive edge than the tumor center (P <0.001). Similarly, the infiltrating density of CD8+T cells and GrB+T cells were highly distributed in the tumor infiltrating edge than the tumor center. While the total number of TILs and the FOXP3+T cells were on the contrary. There was a positive correlation between the density of TLSs and TILs either in the location or the immune phenotype. And a higher frequency of TILs and TLSs often associated with the favorable clinicopathologic parameters. Multivariate analysis revealed that the density of TILs (P= 0.019) and TLSs (P= 0.037) were the independent prognostic predictor for GC patients.ConclusionsThe formation of TLSs predicts an advantageous immune system function and can be considered as a novel biomarker to stratify the overall survival risk of untreated GC patients and as a marker of efficient immunotherapies.

scholarly journals Prognostic role of tumor-infiltrating lymphocytes in gastric cancer

Medicine ◽  
2018 ◽  
Vol 97 (32) ◽  
pp. e11769 ◽  
Author(s):  
Jung Soo Lee ◽  
Hye Sung Won ◽  
Der Sheng Sun ◽  
Ji Hyung Hong ◽  
Yoon Ho Ko
Keyword(s):  
Gastric Cancer ◽  
Tumor Infiltrating Lymphocytes ◽  
Prognostic Role ◽  
Infiltrating Lymphocytes

scholarly journals Prognostic role of tumor-infiltrating lymphocytes in gastric cancer: a meta-analysis

Oncotarget ◽  
2017 ◽  
Vol 8 (34) ◽  
pp. 57386-57398 ◽  
Author(s):  
Xiao Zheng ◽  
Xing Song ◽  
Yingjie Shao ◽  
Bin Xu ◽  
Lujun Chen ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Meta Analysis ◽  
Tumor Infiltrating Lymphocytes ◽  
Prognostic Role ◽  
Infiltrating Lymphocytes

scholarly journals Prognostic Role of Tumor‐Infiltrating Lymphocytes and Tumor Budding in Early Oral Tongue Carcinoma

2021 ◽  
Author(s):  
Yukiko Hori ◽  
Akira Kubota ◽  
Tomoyuki Yokose ◽  
Madoka Furukawa ◽  
Takeshi Matsushita ◽  
...  
Keyword(s):  
Tumor Infiltrating Lymphocytes ◽  
Tumor Budding ◽  
Tongue Carcinoma ◽  
Oral Tongue ◽  
Prognostic Role ◽  
Infiltrating Lymphocytes

scholarly journals Relationship between Prognosis and Apoptotic Index of Tumor Infiltrating Lymphocytes and Cancer Cells in gastric Cancer.

2002 ◽  
Vol 35 (8) ◽  
pp. 1359-1368
Author(s):  
Toshihiro Yasue ◽  
Iwao Kumazawa ◽  
Yasuyuki Sugiyama ◽  
Katsuyuki Kunieda ◽  
Shigetoyo Saji
Keyword(s):  
Gastric Cancer ◽  
Cancer Cells ◽  
Tumor Infiltrating Lymphocytes ◽  
Apoptotic Index ◽  
Infiltrating Lymphocytes

High levels of tumor-infiltrating lymphocytes showed better clinical outcomes in FOLFOX-treated gastric cancer patients

2020 ◽  
Vol 21 (11) ◽  
pp. 751-759
Author(s):  
Wei Li ◽  
Weili Wang ◽  
Ping Liao ◽  
Kun Song ◽  
Zhanwei Zhu ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
T Cells ◽  
Clinical Outcomes ◽  
Cox Regression ◽  
Tumor Infiltrating Lymphocytes ◽  
Median Number ◽  
Cox Regression Analysis ◽  
T Cell Infiltration ◽  
Gastric Cancer Patients ◽  
Infiltrating Lymphocytes

Background: Tumor-infiltrating lymphocytes (TILs) and postoperative chemotherapeutics interact in the tumor micro-environment. This interaction has not been well investigated in gastric cancer. Materials & methods: A total of 129 patients were divided into high or low TILs based on the median number of positive CD3+ and FoxP3+ T cells, which was assessed by immunocytochemistry. Results: Cox regression analysis showed that the stage III disease with shorter overall survival was significant. The analysis showed that high numbers of CD3+ or FoxP3+ T cells have better clinical outcomes in FOLFOX-treated patients. Conclusion: High CD3+ and FoxP3+ T-cell infiltration was associated with better clinical outcomes in patients with gastric cancer treated with FOLFOX, suggesting TILs incorporated into algorithms to improve the therapeutic efficacy of optimal chemotherapy.

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