Prognostic Role of Tumor‐Infiltrating Lymphocytes and Tumor Budding in Early Oral Tongue Carcinoma

Background: Sex-determining region Y-box 2 (SOX2) is a transcriptional factor that drives embryonic stem cells to neuroendocrine cells in lung development and is highly expressed in small-cell lung cancer (SCLC). However, the prognostic role of SOX2 and its relationship with tumor-infiltrating lymphocytes (TILs) has not been determined in SCLC. Herein, we assessed the expression of SOX2 and CD8+ TILs to obtain insights into the prognostic role of SOX2 and CD8+ TILs in limited-stage (LS)-SCLC. Methods: A total of 75 patients with LS-SCLC was enrolled. The SOX2 expression and CD8+ TILs were evaluated by immunohistochemistry. Results: High SOX2 and CD8+ TIL levels were identified in 52 (69.3%) and 40 (53.3%) patients, respectively. High SOX2 expression was correlated with increased density of CD8+ TILs (p = 0.041). Unlike SOX2, high CD8+ TIL numbers were associated with significantly longer progression-free survival (PFS; 13.9 vs. 8.0 months, p = 0.014). Patients with both high SOX2 expression and CD8+ TIL numbers (n = 29, 38.7%) had significantly longer PFS and overall survival (OS) compared to those from the other groups (median PFS 19.3 vs. 8.4 months; p = 0.002 and median OS 35.7 vs. 17.4 months; p = 0.004, respectively). Multivariate Cox regression analysis showed that the combination of high SOX2 expression and CD8+ TIL levels was an independent good prognostic factor for OS (HR = 0.471, 95% CI, 0.250–0.887, p = 0.02) and PFS (HR = 0.447, 95% CI, 0.250–0.801, p = 0.007) in SCLC. Conclusions: Evaluation of the combination of SOX2 and CD8+ TIL levels may be of a prognostic value in LS-SCLC.

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Unfavorable prognostic role of tumor-infiltrating lymphocytes in hormone-receptor positive, HER2 negative metastatic breast cancer treated with metronomic chemotherapy

The Breast ◽

10.1016/j.breast.2017.05.009 ◽

2017 ◽

Vol 34 ◽

pp. 83-88 ◽

Cited By ~ 11

Author(s):

Emilia Montagna ◽

Andrea Vingiani ◽

Patrick Maisonneuve ◽

Giuseppe Cancello ◽

Federica Contaldo ◽

...

Keyword(s):

Breast Cancer ◽

Metastatic Breast Cancer ◽

Hormone Receptor ◽

Metastatic Breast ◽

Metronomic Chemotherapy ◽

Tumor Infiltrating Lymphocytes ◽

Prognostic Role ◽

Hormone Receptor Positive ◽

Infiltrating Lymphocytes

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Prognostic role of stromal tumor-infiltrating lymphocytes in locally advanced upper tract urothelial carcinoma: A retrospective multicenter study (TSU-02 study)

OncoImmunology ◽

10.1080/2162402x.2020.1861737 ◽

2021 ◽

Vol 10 (1) ◽

pp. 1861737

Author(s):

Sida Cheng ◽

Wenlong Zhong ◽

Kun Xia ◽

Peng Hong ◽

Rongcheng Lin ◽

...

Keyword(s):

Urothelial Carcinoma ◽

Multicenter Study ◽

Locally Advanced ◽

Tumor Infiltrating Lymphocytes ◽

Upper Tract Urothelial Carcinoma ◽

Prognostic Role ◽

Upper Tract ◽

Infiltrating Lymphocytes ◽

Retrospective Multicenter Study

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Prognostic Value of Tumor-Infiltrating Lymphocytes in Schistosomiasis-Associated Colorectal Cancer

10.21203/rs.3.rs-736856/v1 ◽

2021 ◽

Author(s):

Weixia Wang ◽

Yingyi Zhang ◽

Jican Liu ◽

Hongyan Jing ◽

Kui Lu ◽

...

Keyword(s):

Colorectal Cancer ◽

Multivariate Analysis ◽

Prognostic Factors ◽

Lymph Nodes ◽

Vascular Invasion ◽

Prognostic Value ◽

Tumor Budding ◽

Prognostic Role ◽

Infiltrating Lymphocytes

Abstract Aim: To investigate the relationship between schistosomiasis and tumour infiltrating lymphocytes (TILs), and the prognostic value of TILs in schistosomal colorectal cancer (CRC).Background: The association between TILs and CRC has long been suggested in the literature, but the association between TILs and schistosomiasis and the prognositic role of TILs in schistosomal CRC has never been reported previously.Methods: Hematoxylin and eosin (H&E)-stained sections of 351 CRC tumours, which were completely resected, were evaluated for density of TILs in intratumoural (iTIL) and stromal compartments (sTIL). Its relationship with clinicopathological features, including schistosomiasis, and clinical outcomes were evaluated and the prognostic role of sTILs in schistosomal CRC was explored.Results: Stromal TILs infiltration were correlated with smaller tumor size，less deeper pathological T stage, absence lymph node metastasis and less number of tumor budding (p＜0.05). However, there were no association between sTILs and shicstosomiasis. In the whole cohort, multivariate analysis identified gender, TNM Stage, Schistosomiasis, sTILs, lymph vascular invasion, lymph nodes positive for CRC were independent prognostic factors that associated with overall survival (OS) in CRC (p < 0.05). Patients were divided into two groups based on schistosomiasis infection status: colorectal cancer associated with schistosomiasis (CRC-NS set) and colorectal cancer without schistosomiasis (CRC-S set ). In the CRC-NS set, multivariate analysis demonstrated that tumor budding, sTILs, lymph vascular invasion, lymph nodes positive for CRC were independent prognostic factors that associated with OS (p < 0.05). However, there were no association between sTILs and OS in CRC-S set (p＞0.05). Besides, sTILs were associated with favorable OS in CRC-NS patients but not in CRC-S patients, regardless of age. Conclusion: Stromal TILs in the whole cohort and in the CRC-NS set were identified as an independent prognostic factor, but it was lack of prognostic role in schistosomal CRC. Stromal TILs was associated with less aggressive tumor features. Stromal TILs was associated with OS in CRC-NS patients but not in CRC-S patients, regardless of age.

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Prognostic role of CD8+ tumor-infiltrating lymphocytes in stage III colorectal cancer with and without microsatellite instability

Human Pathology ◽

10.1016/j.humpath.2004.01.022 ◽

2004 ◽

Vol 35 (7) ◽

pp. 808-816 ◽

Cited By ~ 146

Author(s):

F PRALL

Keyword(s):

Colorectal Cancer ◽

Microsatellite Instability ◽

Tumor Infiltrating Lymphocytes ◽

Stage Iii ◽

Prognostic Role ◽

Infiltrating Lymphocytes

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Prognostic Role of Tumor-Infiltrating Lymphocytes in Lung Cancer: a Meta-Analysis

Cellular Physiology and Biochemistry ◽

10.1159/000438523 ◽

2015 ◽

Vol 37 (4) ◽

pp. 1560-1571 ◽

Cited By ~ 85

Author(s):

Yiting Geng ◽

Yingjie Shao ◽

Wenting He ◽

Wenwei Hu ◽

Yanjie Xu ◽

...

Keyword(s):

Lung Cancer ◽

T Cells ◽

Cancer Patients ◽

Meta Analysis ◽

Tumor Infiltrating Lymphocytes ◽

Prognostic Role ◽

Lung Cancer Patients ◽

High Level ◽

Infiltrating Lymphocytes

Background/Aims: The role of Tumor-infiltrating lymphocytes (TILs) in the prognosis of patients with lung cancer is still controversial. We performed a meta-analysis to evaluate the prognostic role of TILs in lung cancer. Methods: Studies were recruited by searching PubMed, Embase and the Cochrane Library and assessed by further quality evaluation. The pooled hazard ratios (HRs) with 95% confidence intervals (CIs) were calculated to investigate the association between TIL subsets and lung cancer patients' outcome. Results: A total of 29 articles including 8,600 patients were enrolled into the meta-analysis. Our results indicated that high level of CD8+ cells infiltration in tumor stroma (TS) or tumor nest (TN) was associated with better OS in lung cancer patients (HR = 0.76, 95% CI 0.62-0.93, P = 0.006; HR = 0.80, 95% CI 0.67-0.96; P = 0.018, respectively). Similar results could be also observed in CD3+ T cells infiltration. High CD4+ T lymphocytes infiltration in TS was explicitly accompanied by better OS (HR = 0.65, 95% CI 0.46-0.91; P = 0.013), rather than in TN. In contrast, high density of FOXP3+ T cells infiltration in TS showed a poor PFS (HR = 2.67, 95% CI, 1.74-4.08, P < 0.001). Conclusion: This meta-analysis clarified that high level of CD8+ and CD3+ T cells infiltration in TS or TN, and high CD4+ T lymphocytes infiltration in TS showed better OS in lung cancer patients, whereas high density of FOXP3+ T cells infiltration in TS could be recognized as a negative prognostic factor.

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Prognostic role of programmed-death ligand 1 (PD-L1) expressing tumor infiltrating lymphocytes in testicular germ cell tumors

Oncotarget ◽

10.18632/oncotarget.15585 ◽

2017 ◽

Vol 8 (13) ◽

pp. 21794-21805 ◽

Cited By ~ 32

Author(s):

Michal Chovanec ◽

Zuzana Cierna ◽

Viera Miskovska ◽

Katarina Machalekova ◽

Daniela Svetlovska ◽

...

Keyword(s):

Germ Cell ◽

Germ Cell Tumors ◽

Tumor Infiltrating Lymphocytes ◽

Testicular Germ Cell Tumors ◽

Prognostic Role ◽

Testicular Germ Cell ◽

Programmed Death Ligand 1 ◽

Programmed Death ◽

Infiltrating Lymphocytes

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Prognostic value of tumor-infiltrating lymphocytes in gliomas: A Systematic Review

10.21203/rs.3.rs-41045/v1 ◽

2020 ◽

Author(s):

yanlin song ◽

Jing Zhang ◽

Yu Liu ◽

Xuelei Ma

Keyword(s):

Poor Prognosis ◽

Progression Free Survival ◽

Tumor Infiltrating Lymphocytes ◽

High Density ◽

Cochrane Library ◽

Potential Candidate ◽

Prognostic Role ◽

China National Knowledge Infrastructure ◽

Infiltrating Lymphocytes

Abstract Background: Glioma is the most common primary brain tumor with poor prognosis. Some studies have learned the prognostic role of tumor infiltrating lymphocytes (TILs) in gliomas. But conflict conclusions were drawn by these studies. In order to reach an agreement, we systematically performed a meta-analysis.Method: A systematic literature research was conducted on the Web of Science, EMBASE, PubMed, Cochrane Library and China National Knowledge Infrastructure. The eligible articles which met the inclusion criteria were included in our study. The clinical outcomes of included patients were defined as progression-free survival (PFS) and overall survival (OS). The basic characteristics and relevant data were extracted. Hazard ratios (HRs) with 95% confidence intervals (CIs) were pooled to evaluate the prognostic role of TILs in gliomas. Newcastle Ottawa Scale (NOS) was used to assess the quality of included studies.Results: Eight articles published from 2008 to 2019 were finally included in our study. And 25 studies were conducted in these articles. We assessed the prognostic role of TILs in gliomas by subgroup analysis according to the subtypes of TILs. The pooled HRs for OS revealed that high density of CD3+ and CD4+ TILs were related to the poor prognosis of gliomas (HR for CD3+ TILs=1.266; HR for CD4+ TILs= 2.128). The pooled HR for PFS indicated that only high density of FOXP3+ TILs were related to poor prognosis (HR=2.785; 95%CI=1.848, 4.197).Conclusion: High density of CD3+ and CD4+ TILs may be a potential candidate for predicting poor OS of gliomas while high density of FOXP3+ TILs may serve as a good biomarker for predicting poor PFS of gliomas.

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