scholarly journals Applications of the Amniotic Membrane in Vitreoretinal Surgery

2020 ◽  
Vol 9 (8) ◽  
pp. 2675
Author(s):  
Tomaso Caporossi ◽  
Ruggero Tartaro ◽  
Daniela Bacherini ◽  
Bianca Pacini ◽  
Lorenzo De Angelis ◽  
...  
Keyword(s):  
Retinal Detachment ◽  
Amniotic Membrane ◽  
Surgical Techniques ◽  
Vitreoretinal Surgery ◽  
Recovery Process ◽  
Age Related Macular Degeneration ◽  
Human Amniotic Membrane ◽  
Serous Macular Detachment ◽  
Age Related ◽  
Retinal Pathologies

Recently, the use of the human amniotic membrane (hAM) has been extended to treat retinal disorders, such as macular holes that failed to close and retinal tears. The hAM has demonstrated the induction of a recovery process of the external retinal layers involving the external limiting membrane (ELM) and the ellipsoid zone (EZ). After that, the application of the hAM for retinal pathologies was extended to large macular tears, high myopic retinal detachment associated with MH, paravascular tears, serous macular detachment associated with optic pit, complicated retinal detachment and advanced age-related macular degeneration (AMD). The hAM has shown a potential in repairing retinal tissue through a regeneration process. This review aims to highlight the use of the hAM in various vitreo-retinal surgical fields, and to confront it with other cutting-edge surgical techniques used to treat challenging vitreo-retinal pathologies.

Human Amniotic Membrane Plug to Restore Age-Related Macular Degeneration Photoreceptor Damage

2020 ◽  
Vol 4 (10) ◽  
pp. 996-1007 ◽  
Author(s):  
Stanislao Rizzo ◽  
Tomaso Caporossi ◽  
Ruggero Tartaro ◽  
Lucia Finocchio ◽  
Bianca Pacini ◽  
...  
Keyword(s):  
Macular Degeneration ◽  
Amniotic Membrane ◽  
Age Related Macular Degeneration ◽  
Human Amniotic Membrane ◽  
Age Related ◽  
Photoreceptor Damage

scholarly journals Insights on the Human Amniotic Membrane in Clinical Practice with a Focus on the New Applications in Retinal Surgery

2020 ◽  
Author(s):  
Ruggero Tartaro ◽  
Tomaso Caporossi ◽  
Gianni Virgili ◽  
Francesco Barca ◽  
Fabrizio Giansanti ◽  
...  
Keyword(s):  
Amniotic Membrane ◽  
Anterior Segment ◽  
Age Related Macular Degeneration ◽  
Human Amniotic Membrane ◽  
Retinal Surgery ◽  
Age Related ◽  
Macular Holes ◽  
Retinal Breaks ◽  
Tissue Healing ◽  
New Applications

Lay SummaryRecently, the use of the human amniotic membrane (hAM) has been extended to treat retinal disorders such as refractory macular holes, retinal breaks and dry and wet age-related macular degeneration. Not only the hAM has proved to be an excellent tool for repairing retinal tissue, but it has also shown a promising regeneration potential. This review aims to highlight the novel use of the hAM in treating retinal diseases. Although the hAM has been used in the ocular anterior segment reconstruction for more than 60 years, in the last 2 years, we have found in literature articles showing the use of the hAM in the retinal surgery field with interesting results in terms of tissue healing and photoreceptor regeneration.

scholarly journals Visual Outcomes of Macula-Involving Rhegmatogenous Retinal Detachment in Patients with and Without Age-Related Macular Degeneration

2022 ◽  
Author(s):  
P. Barrett Paulk ◽  
Dala Eloubeidi ◽  
John O. Mason III ◽  
Christine A. Curcio ◽  
Jason N. Crosson ◽  
...  
Keyword(s):  
Visual Acuity ◽  
Retinal Detachment ◽  
Macular Degeneration ◽  
Rhegmatogenous Retinal Detachment ◽  
Age Related Macular Degeneration ◽  
Light Perception ◽  
Postoperative Visual Acuity ◽  
Age Related ◽  
Functional Vision ◽  
Better Than

Abstract Background Patients presenting with macula-off rhegmatogenous retinal detachment (RRD) with concomitant age-related macular degeneration (AMD) and their treating physicians would benefit from knowledge regarding the visual prognosis after repair. The prognosis for such patients is not well known. The purpose of this study is to compare visual outcomes in macula-off RRD in eyes with AMD versus a group of comparison eyes without AMD. Methods This was a retrospective chart review of 1,149 patients. A total of 191 eyes met study criteria, 162 non-AMD eyes (controls) and 29 AMD eyes. The main outcome measure was postoperative visual acuity in control eyes versus AMD eyes, and this was compared using Fisher’s exact test. Results There was a statistically significant difference in postoperative visual acuity by AMD status, with those without AMD having a higher frequency of Count Fingers (CF), Hand Motion (HM), Light Perception (LP), or No Light Perception (NLP) vision (p = 0.023). More specifically 5.56% of non-AMD eyes and 3.45% of AMD eyes were 20/40 or better, 77.16% of non-AMD and 55.17% of AMD eyes were worse than 20/40 and better than 20/200, 10.49% of non-AMD eyes and 37.93% of AMD eyes were 20/200 or worse, and there were 11 eyes in the non-AMD group with CF, HM, LP, or NLP vision while there was only 1 eye in the AMD group with CF vision. Conclusions Though postoperative visual acuity was worse in the non-AMD group with a higher frequency of patients having final vision of CF, HM, LP, or NLP, this is not likely a clinically significant finding. Rather, it is a function of the difference in sample size and composition between the two groups. Importantly, this study suggests AMD patients can expect similar outcomes to non-AMD patients after RRD repair. Our study suggests that approximately 58% of patients with AMD can expect to maintain functional vision better than 20/200. We conclude that AMD patients can achieve functional vision after RRD surgery, similar to those without AMD. These findings may be helpful in guiding realistic expectations of AMD patients with RRD.

scholarly journals Improving Efficiency in Separating Blood Vessels from Retinal Images with Deep Learning Techniques

2019 ◽  
Vol 8 (2S11) ◽  
pp. 3637-3640
Keyword(s):  
Diabetic Retinopathy ◽  
Deep Learning ◽  
Macular Degeneration ◽  
Blood Vessels ◽  
Age Related Macular Degeneration ◽  
Retinal Images ◽  
Retinal Vessels ◽  
Age Related ◽  
Learning Techniques ◽  
Retinal Pathologies

Retinal vessels ID means to isolate the distinctive retinal configuration issues, either wide or restricted from fundus picture foundation, for example, optic circle, macula, and unusual sores. Retinal vessels recognizable proof investigations are drawing in increasingly more consideration today because of pivotal data contained in structure which is helpful for the identification and analysis of an assortment of retinal pathologies included yet not restricted to: Diabetic Retinopathy (DR), glaucoma, hypertension, and Age-related Macular Degeneration (AMD). With the advancement of right around two decades, the inventive methodologies applying PC supported systems for portioning retinal vessels winding up increasingly significant and coming nearer. Various kinds of retinal vessels segmentation strategies discussed by using Deep Learning methods. At that point, the pre-processing activities and the best in class strategies for retinal vessels distinguishing proof are presented.

Human amniotic membrane patch and platelet-rich plasma to promote retinal hole repair in a recurrent retinal detachment

2020 ◽  
pp. 112067212095331
Author(s):  
Federico Di Tizio ◽  
Irene Gattazzo ◽  
Federico Di Staso ◽  
Mariachiara Di Pippo ◽  
Fabio Guglielmelli ◽  
...  
Keyword(s):  
Retinal Detachment ◽  
Surgical Technique ◽  
Amniotic Membrane ◽  
Silicone Oil ◽  
Platelet Rich Plasma ◽  
High Viscosity ◽  
Pathologic Myopia ◽  
Human Amniotic Membrane ◽  
Silicon Oil ◽  
Retinal Hole

Purpose: To present a modified surgical technique, based on a combination of human amniotic membrane (hAM) patch and autologous Platelet-rich plasma (PRP) in a case of recurrent retinal detachment (RRD) due to a perivascular retinal hole over an area of staphyloma in an eye with pathologic myopia. Methods: Presenting the surgical technique with the disposal of surgical video. After performing 23-gauge pars plana vitrectomy (PPV) the hAM patch was inserted under the neuroretina through the perivascular hole and PRP was injected on top to speed up the closure of the hole. To complete the surgical procedure High Viscosity Silicon oil (5000cst) was used as tamponade. The patient was prescribed to maintain a face-down position for the first 3 days after the operation. Follow-up was evaluated through Optical coherence tomography (OCT) scans. Results: The 3 days postoperative OCT showed a flat retina with the filling of the myopic staphyloma. The hAM patch was well positioned and the retinal hole could not be identified. At 6 weeks from intervention, the site of the retinal hole at OCT scan was covered by new tissue. Silicone oil was removed 3 months later with no recurrence. Conclusion: hAM transplantation is a novel technique in case of retinal detachment recurrences to seal retinal holes over high myopic chorioretinal atrophy. The adjunctive use of PRP and high viscosity silicon oil allows to reducing the standard face-down positioning timing, representing a valid solution for elderly patients who have difficulties maintaining the position for long periods.

BRIDGE ARCH-SHAPED SEROUS RETINAL DETACHMENT IN AGE-RELATED MACULAR DEGENERATION

Retina ◽  
2016 ◽  
Vol 36 (3) ◽  
pp. 476-482 ◽  
Author(s):  
Franck Fajnkuchen ◽  
Salomon Y. Cohen ◽  
Nathalie Thay ◽  
Sandrine Ayrault ◽  
Corinne Delahaye-Mazza ◽  
...  
Keyword(s):  
Retinal Detachment ◽  
Macular Degeneration ◽  
Serous Retinal Detachment ◽  
Age Related Macular Degeneration ◽  
Age Related

scholarly journals Nitrosative Stress in Retinal Pathologies: Review

Antioxidants ◽  
2019 ◽  
Vol 8 (11) ◽  
pp. 543 ◽  
Author(s):  
Antolin Cantó ◽  
Teresa Olivar ◽  
Francisco Javier Romero ◽  
María Miranda
Keyword(s):  
Lipid Membranes ◽  
Nitrosative Stress ◽  
Age Related Macular Degeneration ◽  
Retinal Blood Flow ◽  
Vascular Endothelial ◽  
Nitrogen Species ◽  
Cellular Functions ◽  
Age Related ◽  
Retinal Pathologies

Nitric oxide (NO) is a gas molecule with diverse physiological and cellular functions. In the eye, NO is used to maintain normal visual function as it is involved in photoreceptor light transduction. In addition, NO acts as a rapid vascular endothelial relaxant, is involved in the control of retinal blood flow under basal conditions and mediates the vasodilator responses of different substances such as acetylcholine, bradykinin, histamine, substance P or insulin. However, the retina is rich in polyunsaturated lipid membranes and is sensitive to the action of reactive oxygen and nitrogen species. Products generated from NO (i.e., dinitrogen trioxide (N2O3) and peroxynitrite) have great oxidative damaging effects. Oxygen and nitrogen species can react with biomolecules (lipids, proteins and DNA), potentially leading to cell death, and this is particularly important in the retina. This review focuses on the role of NO in several ocular diseases, including diabetic retinopathy, retinitis pigmentosa, glaucoma or age-related macular degeneration (AMD).

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