Changes in Bihemispheric Structural Connectivity Following Middle Cerebral Artery Infarction

This study investigated the changes in the structural connectivity of the bilateral hemispheres over time following a middle cerebral artery infarction. Eighteen patients in the subacute group and nine patients in the chronic group with mild upper extremity motor impairment (Fugl-Meyer motor assessment score for the upper limb > 43) following middle cerebral artery infarction were retrospectively evaluated in this study. All the patients underwent T1-weighted and diffusion tensor imaging. Tract-based statistical analyses of fractional anisotropy were used to compare the changes in the bilateral structural connectivity with those of age-matched normal controls. The corticospinal tract pathway of the affected hemisphere, corpus callosum, and corona radiata of the unaffected hemisphere had decreased structural connectivity in the subacute group, while the motor association area and anterior corpus callosum in the bilateral frontal lobes had increased structural connectivity in the chronic group. The bilateral hemispheres were influenced even in patients with mild motor impairment following middle cerebral artery infarction, and the structural connectivity of the bilateral hemispheres changed according to the time following the stroke.

Download Full-text

Confabulation Following Injury of the Papez Circuit as a Result of Middle Cerebral Artery Infarction: A Diffusion Tensor Tractography Study

Journal of the Korean Proprioceptive Neuromuscular Facilitation Association ◽

10.21598/jkpnfa.2016.14.1.41 ◽

2016 ◽

Vol 14 (1) ◽

pp. 41-47

Author(s):

Sang-Seok Yeo

Keyword(s):

Middle Cerebral Artery ◽

Cerebral Artery ◽

Diffusion Tensor ◽

Diffusion Tensor Tractography ◽

Middle Cerebral Artery Infarction ◽

Papez Circuit

Download Full-text

Relationship between Diffusion Tensor Fractional Anisotropy and Long-term Motor Outcome in Patients with Hemiparesis after Middle Cerebral Artery Infarction

Journal of Stroke and Cerebrovascular Diseases ◽

10.1016/j.jstrokecerebrovasdis.2014.05.017 ◽

2014 ◽

Vol 23 (9) ◽

pp. 2397-2404 ◽

Cited By ~ 10

Author(s):

Tetsuo Koyama ◽

Kohei Marumoto ◽

Hiroji Miyake ◽

Kazuhisa Domen

Keyword(s):

Middle Cerebral Artery ◽

Fractional Anisotropy ◽

Cerebral Artery ◽

Diffusion Tensor ◽

Middle Cerebral Artery Infarction ◽

Motor Outcome

Download Full-text

The Evaluation of Wallerian Degeneration in Chronic Paediatric Middle Cerebral Artery Infarction Using Diffusion Tensor MR Imaging

Cerebrovascular Diseases ◽

10.1159/000079961 ◽

2004 ◽

Vol 18 (3) ◽

pp. 240-247 ◽

Cited By ~ 32

Author(s):

Pek-Lan Khong ◽

Lin-Jiang Zhou ◽

Gaik-Cheng Ooi ◽

Brian H.Y. Chung ◽

Raymond T.F. Cheung ◽

...

Keyword(s):

Mr Imaging ◽

Middle Cerebral Artery ◽

Cerebral Artery ◽

Wallerian Degeneration ◽

Diffusion Tensor ◽

Middle Cerebral Artery Infarction ◽

Diffusion Tensor Mr Imaging

Download Full-text

Characterizing Diaschisis-Related Thalamic Perfusion and Diffusion After Middle Cerebral Artery Infarction

Stroke ◽

10.1161/strokeaha.120.032464 ◽

2021 ◽

Author(s):

Cong Xia ◽

Jiaying Zhou ◽

Chunqiang Lu ◽

Yuancheng Wang ◽

Tianyu Tang ◽

...

Keyword(s):

Middle Cerebral Artery ◽

Cerebral Artery ◽

Arterial Spin Labeling ◽

Mean Diffusivity ◽

Spin Labeling ◽

Diffusion Kurtosis Imaging ◽

Middle Cerebral Artery Infarction ◽

Chronic Group ◽

Diffusion Kurtosis ◽

And Diffusion

Background and Purpose: Ipsilateral thalamic diaschisis (ITD) initially describes functional depression of the thalamus ipsilateral to a supratentorial lesion, but accumulating evidence has shown morphological changes also occur. Therefore, we aimed to characterize thalamic perfusion and diffusion related to ITD over time and their inter-relationships after middle cerebral artery infarction. Methods: Eighty-five patients with middle cerebral artery infarction who underwent diffusion kurtosis imaging and arterial spin labeling were retrospectively included. ITD was diagnosed as ipsilateral thalamic hypoperfusion present on ≥2 cerebral blood flow maps. The thalamic asymmetrical index was calculated as (ipsilateral value−contralateral value)/contralateral value×100%. Finally, the inter-relationships of thalamic perfusion and diffusion were analyzed. Results: ITD was present in 56/85 patients (65.9%, ITD+). In ITD+ patients, larger abnormal perfusion volume, higher perfusion-infarct mismatch and lower rates of focal hyperperfusion were observed than ITD− patients. Infarction affecting the corona radiata were more frequent among ITD+ patients. Mean kurtosis were slightly but significantly increased within the ipsilateral thalamus compared with the contralateral one in ITD+ patients of subacute and chronic groups, while fractional anisotropy was significantly increased in subacute group but decreased in chronic group for both ITD+ and ITD− patients. Mean diffusivity was significantly increased in ITD+ patients of chronic group. Furthermore, the AI CBF was negatively and significantly correlated with AI MK and AI FA in ITD+ patients in subacute group, and AI MD , even after adjustment for abnormal perfusion volume and days from symptoms onset, in chronic group. ITD+ patients had significantly higher National Institutes of Health Stroke Scale and modified Rankin Scale scores at admission and discharge and also showed a trend to independent association with clinical outcome at discharge. Conclusions: The combination of arterial spin labeling and diffusion kurtosis imaging can reveal early, time-specific thalamic perfusion and diffusion changes after middle cerebral artery infarction. ITD-related hypoperfusion was significantly correlated with underlying microstructural alterations.

Download Full-text

Focal Wallerian degeneration of the corpus callosum in large middle cerebral artery stroke: Serial diffusion tensor imaging

Journal of Magnetic Resonance Imaging ◽

10.1002/jmri.20677 ◽

2006 ◽

Vol 24 (3) ◽

pp. 549-555 ◽

Cited By ~ 64

Author(s):

Rakesh K. Gupta ◽

Sona Saksena ◽

Khader M. Hasan ◽

Atul Agarwal ◽

Mohammad Haris ◽

...

Keyword(s):

Diffusion Tensor Imaging ◽

Corpus Callosum ◽

Middle Cerebral Artery ◽

Cerebral Artery ◽

Wallerian Degeneration ◽

Diffusion Tensor ◽

Middle Cerebral Artery Stroke

Download Full-text

Crossed cerebellar diaschisis in patients with acute middle cerebral artery infarction: Occurrence and perfusion characteristics

Journal of Cerebral Blood Flow & Metabolism ◽

10.1177/0271678x15617953 ◽

2015 ◽

Vol 36 (4) ◽

pp. 743-754 ◽

Cited By ~ 30

Author(s):

Wieland H Sommer ◽

Christine Bollwein ◽

Kolja M Thierfelder ◽

Alena Baumann ◽

Hendrik Janssen ◽

...

Keyword(s):

Middle Cerebral Artery ◽

Cerebral Artery ◽

Symptom Onset ◽

Ct Perfusion ◽

Clinical Factors ◽

Middle Cerebral Artery Infarction ◽

Whole Brain ◽

Crossed Cerebellar Diaschisis ◽

Brain Ct ◽

Cerebellar Diaschisis

We aimed to investigate the overall prevalence and possible factors influencing the occurrence of crossed cerebellar diaschisis after acute middle cerebral artery infarction using whole-brain CT perfusion. A total of 156 patients with unilateral hypoperfusion of the middle cerebral artery territory formed the study cohort; 352 patients without hypoperfusion served as controls. We performed blinded reading of different perfusion maps for the presence of crossed cerebellar diaschisis and determined the relative supratentorial and cerebellar perfusion reduction. Moreover, imaging patterns (location and volume of hypoperfusion) and clinical factors (age, sex, time from symptom onset) resulting in crossed cerebellar diaschisis were analysed. Crossed cerebellar diaschisis was detected in 35.3% of the patients with middle cerebral artery infarction. Crossed cerebellar diaschisis was significantly associated with hypoperfusion involving the left hemisphere, the frontal lobe and the thalamus. The degree of the relative supratentorial perfusion reduction was significantly more pronounced in crossed cerebellar diaschisis-positive patients but did not correlate with the relative cerebellar perfusion reduction. Our data suggest that (i) crossed cerebellar diaschisis is a common feature after middle cerebral artery infarction which can robustly be detected using whole-brain CT perfusion, (ii) its occurrence is influenced by location and degree of the supratentorial perfusion reduction rather than infarct volume (iii) other clinical factors (age, sex and time from symptom onset) did not affect the occurrence of crossed cerebellar diaschisis.

Download Full-text

Structural brain signature of cognitive decline in Parkinson’s disease: DTI-based evidence from the LANDSCAPE study

Therapeutic Advances in Neurological Disorders ◽

10.1177/1756286419843447 ◽

2019 ◽

Vol 12 ◽

pp. 175628641984344 ◽

Cited By ~ 3

Author(s):

Martin Gorges ◽

Hans-Peter Müller ◽

Inga Liepelt-Scarfone ◽

Alexander Storch ◽

Richard Dodel ◽

...

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

White Matter ◽

Corpus Callosum ◽

Cognitive Decline ◽

Diffusion Tensor ◽

Structural Connectivity ◽

Structural Data ◽

The Body ◽

Normal Cognitive Function

Background: The nonmotor symptom spectrum of Parkinson’s disease (PD) includes progressive cognitive decline mainly in late stages of the disease. The aim of this study was to map the patterns of altered structural connectivity of patients with PD with different cognitive profiles ranging from cognitively unimpaired to PD-associated dementia. Methods: Diffusion tensor imaging and neuropsychological data from the observational multicentre LANDSCAPE study were analyzed. A total of 134 patients with PD with normal cognitive function (56 PD-N), mild cognitive impairment (67 PD-MCI), and dementia (11 PD-D) as well as 72 healthy controls were subjected to whole-brain-based fractional anisotropy mapping and covariance analysis with cognitive performance measures. Results: Structural data indicated subtle changes in the corpus callosum and thalamic radiation in PD-N, whereas severe white matter impairment was observed in both PD-MCI and PD-D patients including anterior and inferior fronto-occipital, uncinate, insular cortices, superior longitudinal fasciculi, corona radiata, and the body of the corpus callosum. These regional alterations were demonstrated for PD-MCI and were more pronounced in PD-D. The pattern of involved regions was significantly correlated with the Consortium to Establish a Registry for Alzheimer’s Disease (CERAD) total score. Conclusions: The findings in PD-N suggest impaired cross-hemispherical white matter connectivity that can apparently be compensated for. More pronounced involvement of the corpus callosum as demonstrated for PD-MCI together with affection of fronto-parieto-temporal structural connectivity seems to lead to gradual disruption of cognition-related cortico-cortical networks and to be associated with the onset of overt cognitive deficits. The increase of regional white matter damage appears to be associated with the development of PD-associated dementia.

Download Full-text