scholarly journals OCT Based Interpretation of the Optic Nerve Head Anatomy and Prevalence of Optic Disc Drusen in Patients with Idiopathic Intracranial Hypertension (IIH)

Life ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. 584
Author(s):  
Elisabeth Arnberg Wibroe ◽  
Lasse Malmqvist ◽  
Steffen Hamann
Keyword(s):  
Optic Nerve ◽  
Intracranial Hypertension ◽  
Optic Disc ◽  
Optic Nerve Head ◽  
Idiopathic Intracranial Hypertension ◽  
Ganglion Cell Layer ◽  
Cell Layer ◽  
Fiber Layer ◽  
Nerve Fiber Layer Thickness ◽  
Optic Disc Drusen

We aimed to systematically examine the optic nerve head anatomy in patients with idiopathic intracranial hypertension (IIH) using a standardized optical coherence tomography (OCT) protocol. The study retrospectively included 32 patients diagnosed from 2014 to 2021 with IIH. Using OCT, in accordance with a standardized scanning protocol for patients with optic disc drusen, the presence of optic disc drusen, prelaminar hyperreflective lines, peripapillary hyperreflective ovoid mass-like structures, the retinal nerve fiber layer thickness, and macular ganglion cell layer volume was obtained. Optic disc drusen were found in 3.1%, hyperreflective lines in 31.3%, and peripapillary hyperreflective ovoid mass-like structures in 81.3% of all IIH patients at least three months after the time of diagnosis. We found no significant differences in retinal nerve fiber layer thickness or macular ganglion cell layer volume in patients with hyperreflective lines or PHOMS respectively compared to patients without hyperreflective lines (p = 0.1285 and p = 0.1835). In conclusion, the prevalence of optic disc drusen in IIH patients is similar to the reported prevalence in the general population. The high prevalence of hyperreflective lines and peripapillary hyperreflective ovoid mass-like structures in IIH patients suggest these structures be a result of crowding in the optic nerve head caused by papilledema.

scholarly journals Comparing characteristics of the optic nerve head among subjects with suspected glaucoma in different ages of onset

2018 ◽  
Vol 146 (3-4) ◽  
pp. 136-142
Author(s):  
Vesna Maric ◽  
Vujica Markovic ◽  
Marija Bozic ◽  
Ivan Marjanovic
Keyword(s):  
Optic Nerve ◽  
Nerve Fiber ◽  
Layer Thickness ◽  
Optic Disc ◽  
Retinal Nerve Fiber Layer ◽  
Optic Nerve Head ◽  
Fiber Layer ◽  
Nerve Fiber Layer Thickness ◽  
Neuroretinal Rim ◽  
Disc Area

Introduction/Objective. Evaluation of the optic nerve head (ONH) is an inevitable procedure in the diagnosis of glaucoma. One of the most common imaging techniques for a quantitative assessment of the topography of the ONH is the Heidelberg retinal tomography II (HRT II). The aim of this study was to determine quantitative stereometric parameters of the ONH by using the HRT II and to investigate any damage of neuroretinal rim in children with suspected glaucoma and compared these data with the group of adults with suspected glaucoma. Methods. This comparative study included 167 (167 eyes) children aged 11?3 years with suspected juvenile glaucoma and 175 adult participants (175 eyes), aged 60?3 years, also with suspected glaucoma, examined between January 2013 and April 2014. Optic nerve head topography and retinal nerve fiber layer thickness measurements were assessed using a HRT II. Results. Data analysis in this study showed that the average mean values for children/adults were: disc area (mm2) 2.828?0.489/2.663?0.412 (p<0.001); rim area (mm2) 1.873?0.391/1.667?0.275 (p<0.001); cup/disc area ratio 0.369?0.125/0.369?0.101 (p=0.530); mean retinal nerve fiber layer thickness (mm) 0.223?0.078/0.219?0.055 (p=0.494). Statistically significant difference in damage of neuroretinal rim, between children and adults, was found in temporal (T) and temporal-inferior (Ti) segments. Conclusions. There were differences in some of the investigated quantitative parameters of the ONH between children and adults, as optic disc size, cup and rim area and rim volume. By using MRA, difference in the damage of the neuroretinal rim, when comparing children and adult optic discs appeared only in T and Ti segments, which means that optic disc cupping has spread more in children than in adults.

3D Optic Nerve Head Segmentation in Idiopathic Intracranial Hypertension

2012 ◽  
pp. 262-267 ◽  
Author(s):  
Ella Maria Kadas ◽  
Falko Kaufhold ◽  
Christian Schulz ◽  
Friedemann Paul ◽  
Konrad Polthier ◽  
...  
Keyword(s):  
Optic Nerve ◽  
Intracranial Hypertension ◽  
Optic Nerve Head ◽  
Idiopathic Intracranial Hypertension ◽  
Head Segmentation

Spontaneous Skull Base Cerebrospinal Fluid Leaks and Their Relationship to Idiopathic Intracranial Hypertension

2020 ◽  
Vol 35 (1) ◽  
pp. 36-43 ◽  
Author(s):  
Samuel Bidot ◽  
Joshua M. Levy ◽  
Amit M. Saindane ◽  
Kannan M. Narayana ◽  
Michael Dattilo ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Optic Nerve ◽  
Intracranial Hypertension ◽  
Skull Base ◽  
Optic Nerve Head ◽  
Idiopathic Intracranial Hypertension ◽  
Signs And Symptoms ◽  
Csf Leak ◽  
Imaging Evaluation ◽  
Cerebrospinal Fluid Leaks

Background The association between spontaneous skull base cerebrospinal fluid (CSF) leaks and idiopathic intracranial hypertension (IIH) has been suggested, but its significance remains unclear. Objective To estimate the prevalence of IIH in spontaneous skull base CSF leak patients. Methods Systematic collection of demographics, neuro-ophthalmic and magnetic resonance imaging evaluation of spontaneous skull base CSF leak patients seen pre- and post-leak repair in one neuro-ophthalmology service. Patients with preexisting IIH were diagnosed with definite IIH if adequate documentation was provided; otherwise, they were categorized with presumed IIH. Classic radiographic signs of intracranial hypertension and bilateral transverse venous sinus stenosis were recorded. Results Thirty six patients were included (age [interquartile range]: 50 [45;54] years; 94% women; body mass index: 36.8 [30.5;39.9] kg/m2), among whom six (16.7%, [95% confidence interval, CI]: [6.4;32.8]) had a preexisting diagnosis of definite or presumed IIH. Of the remaining 30 patients, four (13.3%, 95%CI: [3.8;30.7]) had optic nerve head changes suggesting previously undiagnosed IIH, while one was newly diagnosed with definite IIH at initial consultation. One out of 29 patients with normal findings of the optic nerve head at presentation developed new onset papilledema following surgery (3.4%, 95%CI: [0.1;17.8]) and was ultimately diagnosed with definite IIH. Overall, the prevalence of definite IIH was 19.4% (95%CI: [8.2;36.0]). Conclusion Striking demographic overlap exists between IIH patients and those with spontaneous CSF leak. Definite IIH was present in approximately 20% of our patients. However, its true prevalence is likely higher than identified by using classic criteria. We therefore hypothesize that an active CSF leak serves as an auto-diversion for CSF, thereby “treating” the intracranial hypertension and eliminating characteristic signs and symptoms at initial presentation.

The Effect of beta-Thalassemia Minor on the Optic Nerve Head Analysis.

Blood ◽  
2005 ◽  
Vol 106 (11) ◽  
pp. 3831-3831 ◽  
Author(s):  
Turker Cetin ◽  
Fatih M. Mutlu ◽  
Ferit Avcu ◽  
Tarkan Mumcuoglu ◽  
Oral Nevruz ◽  
...  
Keyword(s):  
Optic Nerve ◽  
Optic Nerve Head ◽  
Beta Thalassemia ◽  
Fiber Layer ◽  
Topographic Analysis ◽  
Nerve Fiber Layer Thickness ◽  
Neuroretinal Rim ◽  
Thalassemia Minor ◽  
Disc Area ◽  
Area And Volume

Abstract Background: A variety of ophthalmologic findings have been reported in patients with anemia. Aim: To determine the effect of beta-thalassemia minor on the optic nerve head topographic analysis. Methods: A total of 39 beta-thalassemia minor patients were divided into 2 groups. Patients with iron, folic acid, or vitamin B12 deficiency were ruled out. Group 1 comprised 20 patients with anemia, and group 2 comprised 19 patients without anemia. One eye of each patient was included into the study. All subjects underwent complete ocular examination. Optic nerve head topographic analysis was performed by using a confocal scanning laser ophthalmoscope type Heidelberg retina tomograph (HRT). The following stereometric parameters were evaluated: disc area, area and volume of cup, area and volume of neuroretinal rim, measure of cup shape, and mean retinal nerve fiber layer thickness. Results: The mean age of group 1 and 2 were 26.8±7.6 and 25.6±4.5 years, respectively (P=0.91). Their mean disc areas were 2.01±0.3 mm2 and 2.53±0.6 mm2, respectively (P =0.009). The differences between groups for area and volume of cup, area and volume of neuroretinal rim, cup shape measure, and mean retinal nerve fiber layer thickness were insignificant (p>0.05). There was no significant difference between mean intraocular pressure of both groups (p=0.93). Conclusion: In beta-thalassemia minor, patients with anemia, optic disc area showed a statistically significant reduction compared to the patients without anemia. Further clinical trials on ocular blood flow and optic nerve oxygenation changes may highlight the role anemia in the optic nerve head of the beta-thalassemia minor patients.

Retinal ganglion cell layer and visual function in a patient with optic disc drusen

1998 ◽  
Vol 236 (12) ◽  
pp. 904-915 ◽  
Author(s):  
M.-M. Gellrich ◽  
Stephan Neumaier ◽  
Claudia Auw-Hädrich ◽  
Nils-Claudius Gellrich ◽  
Lutz Lothar Hansen
Keyword(s):  
Ganglion Cell ◽  
Optic Disc ◽  
Retinal Ganglion Cell ◽  
Visual Function ◽  
Ganglion Cell Layer ◽  
Cell Layer ◽  
Retinal Ganglion ◽  
Optic Disc Drusen ◽  
Retinal Ganglion Cell Layer
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