scholarly journals Pulsed Laser Deposition Derived Bioactive Glass-Ceramic Coatings for Enhancing the Biocompatibility of Scaffolding Materials

Materials ◽  
2020 ◽  
Vol 13 (11) ◽  
pp. 2615 ◽  
Author(s):  
Ruxandra-Ioana Schitea ◽  
Alexandru Nitu ◽  
Andreea-Aurelia Ciobota ◽  
Andrei-Lucian Munteanu ◽  
Irina-Madalina David ◽  
...  

The purpose of this work was to propose and evaluate a new composition for a bioactive glass-ceramic starting from the well-known 45S5 commercial product. Thus, we developed a modified version, including MgO, an oxide that turned out to induce superior mechanical properties and improved biological response. This had the following molar percentages: 46.1% SiO2, 2.6% P2O5, 16.9% CaO, 10.0% MgO, and 24.4% Na2O. The precursor alkoxides and nitrates were processed by a standard sol-gel technique, resulting in a glass-ceramic target, suitable for laser ablation experiments. Combeite (Na2Ca2Si3O9) was identified as a main crystalline phase within the calcined sol-gel powder, as well as in the case of the target sintered at 900 °C. The thin films were deposited on silicon substrates, at room temperature or 300 °C, being subsequently characterized from the material point of view, as well as in terms of bioactivity in simulated conditions and biocompatibility in relation to human fibroblast BJ cells. The investigations revealed the deposition of nanostructured glassy layers with a low proportion of crystalline domains; it was shown that a higher substrate temperature promoted the formation of surfaces with less irregularities, as a consequence of material arrangement into a shell with better morphological homogeneity. The complex elemental composition of the target was successfully transferred to the coatings, which ensured pronounced mineralization and a stimulating environment for the cell cultures. Thereby, both samples were covered with a thick layer of apatite after immersion in simulated body fluid for 28 days, and the one processed at room temperature was qualified to be the best in relation to the cells.

2010 ◽  
Vol 63 ◽  
pp. 131-140 ◽  
Author(s):  
Olga A. Shilova

Heterogeneous sol-gel systems (suspensions), synthesized by mixing sols and fillers of various dispersity (oxides, minerals, etc.), are successfully used to prepare glass-ceramic coatings. Sol composition (precursor, catalyst, solvent, dopants), filler dispersity and a homogenization mode for obtained suspensions essentially influence the properties of coatings formed. Here ways of the control of properties of heterogeneous sol-gel systems (by using various dopants, additives of organic low- and high-molecular compounds, as well as ultrasound) to reach set electro-physical and mechanical characteristics of coatings are considered in details. A number of examples of applications of glass-ceramic and hybrid coatings as well as ‘skin’ - layers are resulted.


2002 ◽  
Vol 25 (5) ◽  
pp. 419-429 ◽  
Author(s):  
S. Abiraman ◽  
H. K. Varma ◽  
T. V. Kumari ◽  
P. R. Umashankar ◽  
Annie John

2007 ◽  
Vol 330-332 ◽  
pp. 169-172 ◽  
Author(s):  
Ming Xue ◽  
Jun Ou ◽  
Da Li Zhou ◽  
Dange Feng ◽  
Wei Zhong Yang ◽  
...  

The porous apatite-wollastonite bioactive glass-ceramic (AW-GG) was made from nano-precursor powders derived from sol-gel process, and shaped by dipping method with polymer foam. The physical-chemical properties, bioactivity and biocompatibility of the materials were studied by means of TG, XRD, SEM, TEM and so on. The bioactivity was investigated in simulated body fluid (SBF) and the biocompatibility was evaluated by co-culturing with marrow stromal cells (MSCs). The result shows that: the particle size of the AW precursor powders is 40~100nm; porous AW GC has three-dimensional pored structure with 300~500um macropores and 2~5um micropores; the materials possess high bioactivity and biocompatibility. Porous AW GC may therefore have great potential application as bone tissue engineering scaffold.


2014 ◽  
Vol 70 (a1) ◽  
pp. C939-C939
Author(s):  
Jacques Huot ◽  
Catherine Gosselin ◽  
Thomas Bibienne ◽  
Roxana Flacau

Metal hydrides are interesting materials from a fundamental as well as practical point of view. Hydrogen storage applications have been the main driving force of research on these materials but lately uses such as thermal storage are considered. In this presentation we will review the use of neutron diffraction for the development of new metal hydrides. Two systems will be presented: BCC solid solution alloys and FeTi alloy. Ti-based BCC solid solutions are promising material for hydrogen storage applications which need high volumetric capacity and room temperature operation. One system that has been considered is Ti-V-Cr. Using only X-ray diffraction for structural identification does not provide information about hydrogen localization. Therefore, neutron diffraction is essential for complete determination of this class of hydrides. We will present examples of Ti-V-Cr compounds doped with Zr-Ni alloy. The peculiarity of this type of alloy is that, for neutron diffraction, the scattering lengths of the elements almost cancel. Therefore, the neutron pattern of as-cast alloy shows very small Bragg peaks but the advantage is that the hydride for is very easy to see and analyze. Another good candidate for hydrogen storage applications is the intermetallic compound TiFe which operates at around room temperature (RT) under mild pressure conditions. However one disadvantage of TiFe alloy synthesized by conventional metallurgical method is its poor activation characteristics. The alloy reacts with hydrogen only after complicated activation procedure involving exposure to high temperature (~4000C) and high pressure for several days. Recently we found that by doping this alloy with Zr and Zr7Ni10 the activation could be easily done at room temperature. We present here a neutron diffraction study of these compounds that shows the structural difference between the activated compound and the one cycled under hydrogen.


2009 ◽  
Vol 355 (6) ◽  
pp. 368-372 ◽  
Author(s):  
Zhongkui Hong ◽  
Aixue Liu ◽  
Li Chen ◽  
Xuesi Chen ◽  
Xiabin Jing

2012 ◽  
Vol 32 (8) ◽  
pp. 2292-2298 ◽  
Author(s):  
Annabel Braem ◽  
Bram Neirinck ◽  
Jan Schrooten ◽  
Omer Van der Biest ◽  
Jef Vleugels

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