scholarly journals Guidance Level for Brevetoxins in French Shellfish

Marine Drugs ◽  
2021 ◽  
Vol 19 (9) ◽  
pp. 520
Author(s):  
Nathalie Arnich ◽  
Eric Abadie ◽  
Zouher Amzil ◽  
Marie-Yasmine Dechraoui Bottein ◽  
Katia Comte ◽  
...  
Keyword(s):  
Working Group ◽  
Case Reports ◽  
Human Case ◽  
Portion Size ◽  
Shellfish Poisoning ◽  
Marine Biotoxins ◽  
Toxicological Data ◽  
Set Up ◽  
First Time ◽  
Environmental And Occupational Health

Brevetoxins (BTXs) are marine biotoxins responsible for neurotoxic shellfish poisoning (NSP) after ingestion of contaminated shellfish. NSP is characterized by neurological, gastrointestinal and/or cardiovascular symptoms. The main known producer of BTXs is the dinoflagellate Karenia brevis, but other microalgae are also suspected to synthesize BTX-like compounds. BTXs are currently not regulated in France and in Europe. In November 2018, they have been detected for the first time in France in mussels from a lagoon in the Corsica Island (Mediterranean Sea), as part of the network for monitoring the emergence of marine biotoxins in shellfish. To prevent health risks associated with the consumption of shellfish contaminated with BTXs in France, a working group was set up by the French Agency for Food, Environmental and Occupational Health & Safety (Anses). One of the aims of this working group was to propose a guidance level for the presence of BTXs in shellfish. Toxicological data were too limited to derive an acute oral reference dose (ARfD). Based on human case reports, we identified two lowest-observed-adverse-effect levels (LOAELs). A guidance level of 180 µg BTX-3 eq./kg shellfish meat is proposed, considering a protective default portion size of 400 g shellfish meat.

scholarly journals Review of DSP Toxicity in Ireland: Long-Term Trend Impacts, Biodiversity and Toxin Profiles from a Monitoring Perspective

Toxins ◽  
2019 ◽  
Vol 11 (2) ◽  
pp. 61 ◽  
Author(s):  
Rafael Salas ◽  
Dave Clarke
Keyword(s):  
Water Samples ◽  
Reference Laboratory ◽  
Shellfish Poisoning ◽  
Marine Biotoxins ◽  
Long Line ◽  
Diarrheic Shellfish Poisoning ◽  
First Time ◽  
Long Term Trend ◽  
Marine Institute

The purpose of this work is to review all the historical monitoring data gathered by the Marine Institute, the national reference laboratory for marine biotoxins in Ireland, including all the biological and chemical data from 2005 to 2017, in relation to diarrheic shellfish poisoning (DSP) toxicity in shellfish production. The data reviewed comprises over 25,595 water samples, which were preserved in Lugol’s iodine and analysed for the abundance and composition of marine microalgae by light microscopy, and 18,166 records of shellfish flesh samples, which were analysed using LC-MS/MS for the presence and concentration of the compounds okadaic acid (OA), dinophysistoxins-1 (DTX-1), dinophysistoxins-2 (DTX-2) and their hydrolysed esters, as well as pectenotoxins (PTXs). The results of this review suggest that DSP toxicity events around the coast of Ireland occur annually. According to the data reviewed, there has not been an increase in the periodicity or intensity of such events during the study period. Although the diversity of the Dinophysis species on the coast of Ireland is large, with 10 species recorded, the two main species associated with DSP events in Ireland are D. acuta and D. acuminata. Moreover, the main toxic compounds associated with these species are OA and DTX-2, but concentrations of the hydrolysed esters are generally found in higher amounts than the parent compounds in the shellfish samples. When D. acuta is dominant in the water samples, the DSP toxicity increases in intensity, and DTX-2 becomes the prevalent toxin. Pectenotoxins have only been analysed and reported since 2012, and these compounds had not been associated with toxic events in Ireland; however, in 2014, concentrations of these compounds were quantitated for the first time, and the data suggest that this toxic event was associated with an unusually high number of observations of D. tripos that year. The areas of the country most affected by DSP outbreaks are those engaging in long-line mussel (Mytilus edulis) aquaculture.

World Meteorological Organization

1957 ◽  
Vol 11 (3) ◽  
pp. 541-542
Keyword(s):  
International Organizations ◽  
Working Group ◽  
Arid Zone ◽  
Research Work ◽  
World Meteorological Organization ◽  
Arid Zones ◽  
Regional Association ◽  
Set Up ◽  
First Time ◽  
Future Program

The second session of Regional Association I (Africa) of the World Meteorological Organization (WMO) opened at Las Palmas, Canary Islands, on January 21, 1957, under the presidency of Mr. Jacques Ravet. Twenty members, out of a total membership of 22, were represented by delegates. In addition, four WMO members from outside the region, one non-member territory and two international organizations sent observers who took an active part in the meeting. Two working committees were set up, one to deal with codes, telecommunications and maritime meteorology, and one to study observational networks, climatology and related matters, and arid zone problems. The various parts of the international codes subject to regional agreement were revised; the existing system of meteorological telecommunications in the region was revised in the light of the recommendations of a working group; and the networks of stations making surface and upper-air observations were examined in detail. The need for more upper-air observations from oceanic regions was stressed, and for the first time a regional network of ground radar weather observing stations was laid down. Among other items dealt with at the session were climatological practices and the preparation of a climatic atlas for Africa, and the promotion of hydrometeorological and agrometeorological activities within the region. A working group was set up to ensure better coordination of research work on the hydrometeorological problems of the arid zones within the region. The association decided that in its future program, first priority should be given to the implementation of the recommended observing networks and of the decisions concerning telecommunications.

Cobalt/Lewis Acid Catalysis for Hydrocarbofunctionalization of Alkynes via Cooperative C–H Activation

2020 ◽  
Author(s):  
Chang-Sheng Wang ◽  
Sabrina Monaco ◽  
Anh Ngoc Thai ◽  
Md. Shafiqur Rahman ◽  
Chen Wang ◽  
...  
Keyword(s):  
Catalytic System ◽  
Lewis Acid ◽  
Hydrogen Transfer ◽  
Acid Catalysis ◽  
Rate Limiting Step ◽  
Site Selectivity ◽  
Set Up ◽  
Site Selective ◽  
First Time ◽  
Rate Limiting

A catalytic system comprised of a cobalt-diphosphine complex and a Lewis acid (LA) such as AlMe3 has been found to promote hydrocarbofunctionalization reactions of alkynes with Lewis basic and electron-deficient substrates such as formamides, pyridones, pyridines, and azole derivatives through site-selective C-H activation. Compared with known Ni/LA catalytic system for analogous transformations, the present catalytic system not only feature convenient set up using inexpensive and bench-stable precatalyst and ligand such as Co(acac)3 and 1,3-bis(diphenylphosphino)propane (dppp), but also display distinct site-selectivity toward C-H activation of pyridone and pyridine derivatives. In particular, a completely C4-selective alkenylation of pyridine has been achieved for the first time. Mechanistic stidies including DFT calculations on the Co/Al-catalyzed addition of formamide to alkyne have suggested that the reaction involves cleavage of the carbamoyl C-H bond as the rate-limiting step, which proceeds through a ligand-to-ligand hydrogen transfer (LLHT) mechanism leading to an alkyl(carbamoyl)cobalt intermediate.

scholarly journals A systematic review of historical and current trends in Chagas disease

2021 ◽  
Vol 8 ◽  
pp. 204993612110337
Author(s):  
Diego-Abelardo Álvarez-Hernández ◽  
Rodolfo García-Rodríguez-Arana ◽  
Alejandro Ortiz-Hernández ◽  
Mariana Álvarez-Sánchez ◽  
Meng Wu ◽  
...  
Keyword(s):  
Systematic Review ◽  
Chagas Disease ◽  
Case Reports ◽  
Clinical Manifestations ◽  
Human Case ◽  
Acute Stage ◽  
Diagnostic Tools ◽  
Chronic Stage ◽  
Pubmed Database ◽  
Trypanocidal Drugs

Introduction: Chagas disease (CD) is caused by Trypanosoma cruzi. When acquired, the disease develops in stages. For diagnosis, laboratory confirmation is required, and an extensive assessment of the patient’s health should be performed. Treatment consists of the administration of trypanocidal drugs, which may cause severe adverse effects. The objective of our systematic review was to analyze data contained in the CD published case reports to understand the challenges that patients and clinicians face worldwide. Materials and methods: We performed a systematic review following the PRISMA guidance. PubMed database was explored using the terms ‘American trypanosomiasis’ or ‘Chagas disease’. Results were limited to human case reports written in English or Spanish. A total of 258 reports (322 patients) were included in the analysis. Metadata was obtained from each article. Following this, it was analyzed to obtain descriptive measures. Results: From the sample, 56.2% were males and 43.8% were females. Most cases were from endemic countries (85.4%). The most common clinical manifestations were fever during the acute stage (70.0%), dyspnea during the chronic stage in its cardiac form (53.7%), and constipation during the chronic stage in its digestive form (73.7%). Most patients were diagnosed in the chronic stage (72.0%). Treatment was administered in 56.2% of cases. The mortality rate for the acute stage cases was 24.4%, while for the chronic stage this was 28.4%. Discussion: CD is a parasitic disease endemic to Latin America, with increasing importance due to human and vector migration. In this review, we report reasons for delays in diagnosis and treatment, and trends in medical practices. Community awareness must be increased to improve CD’s diagnoses; health professionals should be appropriately trained to detect and treat infected individuals. Furthermore, public health policies are needed to increase the availability of screening and diagnostic tools, trypanocidal drugs, and, eventually, vaccines.

scholarly journals Composite phaeochromocytomas—a systematic review of published literature

2021 ◽  
Author(s):  
K. Dhanasekar ◽  
V. Visakan ◽  
F. Tahir ◽  
S. P. Balasubramanian
Keyword(s):  
Case Reports ◽  
Descriptive Analysis ◽  
Management Strategies ◽  
Gastrointestinal Symptoms ◽  
Rare Condition ◽  
Epidemiological Data ◽  
Human Case ◽  
Rare Tumour ◽  
Palpable Mass

Abstract Introduction Composite phaeochromocytoma is a tumour containing a separate tumour of neuronal origin in addition to a chromaffin cell tumour. This study reports on two cases from a single centre’s records and presents a systematic literature review of composite phaeochromocytomas. Methods In addition to describing 2 case reports, a systematic search of the Medline database from inception up to April 2020 was done for human case reports on composite phaeochromocytomas. Relevant titles and/or abstracts were screened, and full texts were reviewed to identify appropriate studies. Data was extracted and a descriptive analysis of presentation, clinical features, management strategies and outcomes was performed. The quality of included studies was assessed using a critical appraisal checklist. Results There were 62 studies included, with a total of 94 patients. Of 91 patients where data was available, the median (range) age of patients was 48 (4–86) years. Of 90 patients where information was provided, 57% were female. In at least 28% of patients, a genetic cause was identified. Common presenting features include abdominal pain, palpable mass, cardiovascular and gastrointestinal symptoms. The most common tumour component with phaeochromocytoma is ganglioneuroma; other components include ganglioneuroblastoma, neuroblastoma and malignant peripheral nerve sheath tumours. In patients with follow-up data (n=48), 85% of patients were alive and well at a median (range) follow-up time of 18 (0.5–168) months. Conclusion Composite phaeochromocytoma is a rare tumour, with a significant genetic predisposition. This review summarises available epidemiological data, which will be useful for clinicians managing this rare condition.

scholarly journals Stay at Home! Governance Quality and Effectiveness of Lockdown

2021 ◽  
Author(s):  
Vincenzo Alfano ◽  
Salvatore Ercolano
Keyword(s):  
Rule Of Law ◽  
Global Scale ◽  
Considerable Time ◽  
Government Effectiveness ◽  
Governance Indicators ◽  
Regulatory Quality ◽  
Governance Quality ◽  
World Governance Indicators ◽  
Set Up ◽  
First Time

AbstractIn order to control the spread of the COVID-19 pandemic, during the first wave of the pandemic numerous countries decided to adopt lockdown policies. It had been a considerable time since such measures were last introduced, and the first time that they were implemented on such a global scale in a contemporary, information intensive society. The effectiveness of such measures may depend on how citizens perceive the capacity of government to set up and implement sound policies. Indeed, lockdown and confinement policies in general are binding measures that people are not used to, and which raise serious concerns among the population. For this reason governance quality could affect the perception of the benefits related to the government’s choice to impose lockdown, making citizens more inclined to accept it and restrict their movements. In the present paper we empirically investigate the relation between the efficacy of lockdown and governance quality (measured through World Governance Indicators). Our results suggest that countries with higher levels of government effectiveness, rule of law and regulatory quality reach better results in adopting lockdown measures.

Field Determination of Fracture Propagation Mode Using Downhole Pressure Data

2015 ◽  
Author(s):  
Ali Daneshy ◽  
Chad Touchet ◽  
Fred Hoffman ◽  
Mike McKown
Keyword(s):  
Propagation Mode ◽  
Fluid Migration ◽  
Pressure Data ◽  
Isolation System ◽  
Fracture Orientation ◽  
Coiled Tubing ◽  
Treatment Data ◽  
Set Up ◽  
Adjacent Fractures ◽  
First Time

Abstract This paper presents the analysis results of 60 single stage fracturing treatments performed in a horizontal well using cemented casing sleeves and a coiled tubing deployed frac isolation system as the completion method. In this carefully set-up and executed treatment, separation between the toe stages was 97 feet, and near the heel it was 55 feet. Pressure data was collected above and below the retrievable plug used for stage isolation. This data was used for analysis of fracturing treatment data which included mode of propagation, completion efficiency, and a rough estimate of fracture orientation. The analysis showed that; There was no interaction between adjacent fractures during five of the sixty fracturing stages. None of these was in the well interval with shorter fracture spacingFracture shadowing occurred during six fracture stages, again none in the shorter spacing intervalMinor cement defects (micro-annuli) caused some fluid migration into the passive segment of the well. This happened in 27 stages. Of these; In eleven cases the cement defects were plugged after a while, causing the migration of fracturing fluid into the passive interval to stop.In sixteen other cases the fluid migration through cement micro-annuli continued during fracturing.During ten stages, defective zone isolation and fluid migration caused a pressure increase of several hundred psi in the passive segment of the well. But this did not result in extension of passive fractures.The volume of migrated slurry due to inadequate zone isolation was mostly a very small fraction of the injected volume.During five stages poor cement quality hampered stage isolation and caused immediate link between adjacent active and passive intervals and extension of passive fractures.The data indicate possible connection between the active and one passive fracture in four stages.Shorter spacing between stages increased the incidents of fluid migration due to poor cement qualityThe fracturing pressure variations during the treatments did not indicate presence of large stress shadowingA rough estimation of fracture orientation indicates that they were likely to be vertical and nearly perpendicular to the wellbore.The fracture growth pattern can best be described as off-balance. To our knowledge, this is the first time existence of direct communication between adjacent fractures has been observed through actual pressure interference data.

Excavations in the City of London: First Interim Report, 1974–1975

1977 ◽  
Vol 57 (1) ◽  
pp. 31-66 ◽  
Author(s):  
Brian Hobley ◽  
John Schofield ◽  
Tony Dyson ◽  
Peter R. V. Marsden ◽  
Charles Hill ◽  
...  
Keyword(s):  
Urban Archaeology ◽  
Interim Report ◽  
Set Up ◽  
City Of London ◽  
First Time ◽  
The City ◽  
Important Evidence

SummaryThe Department of Urban Archaeology, City of London, was set up in December 1973 as part of Guildhall Museum, now the Museum of London. Since then it has excavated sixteen sites and carried out numerous watching briefs. Most of the formal excavations have been conducted on the vital waterfront sites, made available for the first time, and on the Roman and medieval defences of the City. Important evidence of the elusive Saxon occupation is gradually coming to light, and the work is accompanied by specialist research, particularly finds, environmental and documentary.

scholarly journals Coriolis effects on the elliptical instability in cylindrical and spherical rotating containers

2007 ◽  
Vol 585 ◽  
pp. 323-342 ◽  
Author(s):  
M. LE BARS ◽  
S. LE DIZÈS ◽  
P. LE GAL
Keyword(s):  
Growth Rates ◽  
Close Agreement ◽  
Unstable Mode ◽  
Quantitative Agreement ◽  
Fixed Rate ◽  
Elliptical Instability ◽  
Normal Mode Theory ◽  
Set Up ◽  
First Time ◽  
Selection Of

The effects of the Coriolis force on the elliptical instability are studied experimentally in cylindrical and spherical rotating containers placed on a table rotating at a fixed rate $\tilde{\Omega}^G$. For a given set-up, changing the ratio ΩG of global rotation $\tilde{\Omega}^G$ to flow rotation $\tilde{\Omega}^F$ leads to the selection of various unstable modes due to the presence of resonance bands, in close agreement with the normal-mode theory. No instability occurs when ΩG varies between −3/2 and −1/2 typically. On decreasing ΩG toward −1/2, resonance bands are first discretized for ΩG<0 and progressively overlap for −1/2 ≪ ΩG < 0. Simultaneously, the growth rates and wavenumbers of the prevalent stationary unstable mode significantly increase, in quantitative agreement with the viscous short-wavelength analysis. New complex resonances have been observed for the first time for the sphere, in addition to the standard spin-over. We argue that these results have significant implications in geo- and astrophysical contexts.

scholarly journals Travel associated legionnaires’disease in Europe: 1997 and 1998

1999 ◽  
Vol 4 (11) ◽  
pp. 120-124 ◽  
Author(s):  
E Slaymaker ◽  
C Joseph ◽  
C L R Bartlett
Keyword(s):  
Working Group ◽  
European Working Group ◽  
European Working ◽  
Returning Travellers ◽  
Legionnaires Disease ◽  
Set Up ◽  
Surveillance Scheme

The European Surveillance Scheme for Travel Associated Legionnaires’ Disease was set up by the European Working Group on Legionella Infections (EWGLI) in 1987 to identify cases of legionella infection in returning travellers and to detect outbreaks and cl

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