scholarly journals The influence of mean blood pressure on arterial stiffening and endothelial dysfunction in women with rheumatoid arthritis and systemic lupus erythematosus

Medicina ◽  
2010 ◽  
Vol 46 (8) ◽  
pp. 522 ◽  
Author(s):  
Alma Čypienė ◽  
Jolanta Dadonienė ◽  
Rita Rugienė ◽  
Ligita Ryliškytė ◽  
Milda Kovaitė ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Systemic Lupus Erythematosus ◽  
Blood Pressure ◽  
Pulse Wave Velocity ◽  
Wave Velocity ◽  
Lupus Erythematosus ◽  
Pulse Wave ◽  
Augmentation Index ◽  
Mean Blood Pressure ◽  
Systemic Lupus

Objective. To investigate the carotid-radial pulse wave velocity, augmentation index, and flow-mediated dilation of the brachial artery and factors possibly influencing them in women with rheumatoid arthritis and systemic lupus erythematosus. Material and methods. A total of 63 women with rheumatoid arthritis, 31 with systemic lupus erythematosus, and 72 controls, aged 18–55 years, were examined. Parameters of arterial stiffness, augmentation index and carotid-radial pulse wave velocity, were obtained by applanation tonometry (Sphygmocor (v.7.01) AtCor Medical). Flow-mediated dilatation of the brachial artery, reflecting endothelial function was determined by ultrasound system (Logiq 7, General Electric). Results. The groups of women with rheumatoid arthritis and systemic lupus erythematosus lupus differed from controls regarding augmentation index (P<0.001; P=0.008) and did not differ between each other. Women with systemic lupus erythematosus differed from controls regarding pulse wave velocity (P=0.018), while women with rheumatoid arthritis – did not. Flow-mediated dilatation in both the groups of diseases was not different from controls. In rheumatoid arthritis patients, mean blood pressure was the main explanatory factor for augmentation index and pulse wave velocity; vessel diameter and high-density lipoprotein cholesterol – for flow-mediated dilatation. In women with systemic lupus erythematosus, pulse wave velocity was not related to any of the pending parameters; augmentation index was dependent on organ damage index, age, and mean blood pressure, and flow-mediated dilatation on vessel diameter, body mass index, and disease duration. Conclusions. The mean blood pressure was the major and the only one risk factor of arterial stiffening in rheumatoid arthritis, while the disease damage index played the most important role in the systemic lupus erythematosus group. The mean blood pressure in the systemic lupus erythematosus group was not as important as in the rheumatoid arthritis group, though may have a partial influence.

Volume status and arterial blood pressures are associated with arterial stiffness in hemodialysis patients

2018 ◽  
Vol 41 (7) ◽  
pp. 378-384 ◽  
Author(s):  
Alper Erdan ◽  
Abdullah Ozkok ◽  
Nadir Alpay ◽  
Vakur Akkaya ◽  
Alaattin Yildiz
Keyword(s):  
Blood Pressure ◽  
Arterial Stiffness ◽  
Pulse Wave Velocity ◽  
Wave Velocity ◽  
Pulse Pressure ◽  
Pulse Wave ◽  
Augmentation Index ◽  
Mean Blood Pressure ◽  
Aortic Blood ◽  
Aortic Blood Pressure

Background: Arterial stiffness is a strong predictor of mortality in hemodialysis patients. In this study, we aimed to investigate possible relations of arterial stiffness with volume status determined by bioimpedance analysis and aortic blood pressure parameters. Also, effects of a single hemodialysis session on these parameters were studied. Methods: A total of 75 hemodialysis patients (M/F: 43/32; mean age: 53 ± 17) were enrolled. Carotid-femoral pulse wave velocity, augmentation index, and aortic pulse pressure were measured by applanation tonometry before and after hemodialysis. Extracellular fluid and total body fluid volumes were determined by bioimpedance analysis. Results: Carotid-femoral pulse wave velocity (9.30 ± 3.30 vs 7.59 ± 2.66 m/s, p < 0.001), augmentation index (24.52 ± 9.42 vs 20.28 ± 10.19, p < 0.001), and aortic pulse pressure (38 ± 14 vs 29 ± 8 mmHg, p < 0.001) significantly decreased after hemodialysis. Pre-dialysis carotid-femoral pulse wave velocity was associated with age (r2 = 0.15, p = 0.01), total cholesterol (r2 = 0.06, p = 0.02), peripheral mean blood pressure (r2 = 0.10, p = 0.005), aortic-mean blood pressure (r2 = 0.06, p = 0.02), aortic pulse pressure (r2 = 0.14, p = 0.001), and extracellular fluid/total body fluid (r2 = 0.30, p < 0.0001). Pre-dialysis augmentation index was associated with total cholesterol (r2 = 0.06, p = 0,02), aortic-mean blood pressure (r2 = 0.16, p < 0.001), and aortic pulse pressure (r2 = 0.22, p < 0.001). Δcarotid-femoral pulse wave velocity was associated with Δaortic-mean blood pressure (r2 = 0.06, p = 0.02) and inversely correlated with baseline carotid-femoral pulse wave velocity (r2 = 0.29, p < 0.001). Pre-dialysis Δaugmentation index was significantly associated with Δaortic-mean blood pressure (r2 = 0.09, p = 0.009) and Δaortic pulse pressure (r2 = 0.06, p = 0.03) and inversely associated with baseline augmentation index (r2 = 0.14, p = 0.001). In multiple linear regression analysis (adjusted R2 = 0.46, p < 0.001) to determine the factors predicting Log carotid-femoral pulse wave velocity, extracellular fluid/total body fluid and peripheral mean blood pressure significantly predicted Log carotid-femoral pulse wave velocity (p = 0.001 and p = 0.006, respectively). Conclusion: Carotid-femoral pulse wave velocity, augmentation index, and aortic pulse pressure significantly decreased after hemodialysis. Arterial stiffness was associated with both peripheral and aortic blood pressure. Furthermore, reduction in arterial stiffness parameters was related to reduction in aortic blood pressure. Pre-dialysis carotid-femoral pulse wave velocity was associated with volume status determined by bioimpedance analysis. Volume control may improve not only the aortic blood pressure measurements but also arterial stiffness in hemodialysis patients.

INCREASED AORTIC PULSE WAVE VELOCITY IN MIDDLE AGED WOMEN WITH SYSTEMIC LUPUS ERYTHEMATOSUS

2004 ◽  
Vol 22 (Suppl. 2) ◽  
pp. S145
Author(s):  
N. Bjarnegard ◽  
C. Bengtsson ◽  
G. Sturfelt ◽  
O. Nived ◽  
J. Brodszski ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Pulse Wave Velocity ◽  
Wave Velocity ◽  
Lupus Erythematosus ◽  
Pulse Wave ◽  
Aortic Pulse Wave Velocity ◽  
Middle Aged ◽  
Systemic Lupus

Increased Pulse Wave Velocity in Systemic Lupus Erythematosus: A Meta-Analysis

Angiology ◽  
2017 ◽  
Vol 69 (3) ◽  
pp. 228-235 ◽  
Author(s):  
Peng Wang ◽  
Yan-Mei Mao ◽  
Chan-Na Zhao ◽  
Li-Na Liu ◽  
Xiao-Mei Li ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Pulse Wave Velocity ◽  
Wave Velocity ◽  
Lupus Erythematosus ◽  
Pulse Wave ◽  
Meta Analysis ◽  
Systemic Lupus

scholarly journals Evaluation of Arteriosclerosis Using the Brachial-Ankle Pulse Wave Velocity in Patients with Visceral Lesion-Free Systemic Lupus Erythematosus Characterized by Skin Lesions

2015 ◽  
Vol 9 (1) ◽  
pp. 30-33
Author(s):  
Kimiko Maruyama ◽  
Takaharu Ikeda ◽  
Katsunori Tanaka ◽  
Fukumi Furukawa
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Pulse Wave Velocity ◽  
Wave Velocity ◽  
Lupus Erythematosus ◽  
Vascular Function ◽  
Pulse Wave ◽  
Skin Lesions ◽  
Systemic Lupus ◽  
Cerebrovascular Lesions ◽  
Visceral Lesion

Recently, the cardio-/cerebrovascular lesion-related mortality rate has been high in patients with systemic lupus erythematosus (SLE). In these patients, the risk of cardio-/cerebrovascular lesions is also higher than in the general population. Cardio-/cerebrovascular lesions may occur during long-term follow-up. In this study, we evaluated arteriosclerosis using the brachial-ankle pulse wave velocity (baPWV) in visceral lesion-free SLE patients with skin lesions. In these patients, baPWV was higher than in healthy adults even at a young age. This suggests that baPWV is a possible tool to evaluate the patient’s vascular function, which was difficult to evaluate using a conventional sera arteriosclerosis index. Even when conditions are characterized by skin lesions, it may be important to consider the influence on the cardio-/cerebrovascular systems, as indicated for patients with systemic symptoms.

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