scholarly journals Perceived Positive and Negative Life Changes in Testicular Cancer Survivors

Medicina ◽  
2021 ◽  
Vol 57 (9) ◽  
pp. 993
Author(s):  
Sigrun Vehling ◽  
Karin Oechsle ◽  
Michael Hartmann ◽  
Carsten Bokemeyer ◽  
Anja Mehnert-Theuerkauf
Keyword(s):  
Testicular Cancer ◽  
Cancer Survivors ◽  
Posttraumatic Growth ◽  
Personal Growth ◽  
Psychosocial Support ◽  
Participation Rate ◽  
Good Prognosis ◽  
Life Changes ◽  
Testicular Cancer Survivors

Background and objectives: Despite a generally good prognosis, testicular cancer can be a life-altering event. We explored perceived positive and negative life changes after testicular cancer in terms of frequency, demographic and disease-related predictors, and associations with depression and anxiety. Materials and methods: All testicular cancer survivors receiving follow-up care at two specialized outpatient treatment facilities were approached at follow-up visits or via mail. We assessed a total of N = 164 patients (66% participation rate, mean time since diagnosis: 11.6 years, SD = 7.4) by the Posttraumatic Growth Inventory (PTGI, modified version assessing positive and negative changes for each of 21 items), Patient-Health-Questionnaire-9 (PHQ-9), and Generalized-Anxiety-Disorder-Scale-7 (GAD-7). We conducted controlled multivariate regression analyses. Results: Most survivors (87%) reported at least one positive change (mean number: 7.2, SD = 5.0, possible range: 0–21). The most frequent perceived positive changes were greater appreciation of life (62%), changed priorities in life (62%), and ability rely on others (51%). At least one negative change was perceived by 33% (mean number of changes: 1.1, SD = 2.5). Negative changes were most frequent for decreases in self-reliance (14%), personal strength (11%), and ability to express emotions (9%). A higher socioeconomic status was associated with more positive changes (β = 0.25, 95% CI 0.08 to 0.42); no other association with demographic and disease-related predictors emerged. While positive life changes were not associated with depression (β = −0.05, 95% CI −0.17 to 0.07) and anxiety (β = 0.00, 95% CI −0.13 to 0.13), more negative life changes were significantly associated with higher depression (β = 0.15, 95% CI −0.03 to 0.27) and anxiety (β = 0.23, 95% CI 0.11 to 0.36). There was no significant interaction of positive and negative changes on depression or anxiety. Conclusions: Although positive life changes after testicular cancer are common, a significant number of survivors perceive negative changes in life domains that have been primarily investigated in terms of personal growth. Early identification of and psychosocial support for patients who perceive predominantly negative changes may contribute to prevention of prolonged symptoms of anxiety and depression.

scholarly journals Chronic fatigue in 812 testicular cancer survivors during long-term follow-up: increasing prevalence and risk factors

2015 ◽  
Vol 26 (10) ◽  
pp. 2133-2140 ◽  
Author(s):  
M. Sprauten ◽  
H.S. Haugnes ◽  
M. Brydøy ◽  
C. Kiserud ◽  
T. Tandstad ◽  
...  
Keyword(s):  
Risk Factors ◽  
Testicular Cancer ◽  
Cancer Survivors ◽  
Chronic Fatigue ◽  
Long Term Follow Up ◽  
Testicular Cancer Survivors

scholarly journals Long-Term Follow Up of the Erectile Function of Testicular Cancer Survivors

2019 ◽  
Vol 10 ◽  
Author(s):  
Francesco Pallotti ◽  
Alessandra Petrozzi ◽  
Francesco Cargnelutti ◽  
Antonio Francesco Radicioni ◽  
Andrea Lenzi ◽  
...  
Keyword(s):  
Testicular Cancer ◽  
Cancer Survivors ◽  
Erectile Function ◽  
Long Term Follow Up ◽  
Testicular Cancer Survivors

Early changes in renal function and late cardiovascular disease risk in testicular cancer survivors with 25 years follow-up.

2015 ◽  
Vol 33 (15_suppl) ◽  
pp. 4541-4541
Author(s):  
Sjoukje Lubberts ◽  
Joost A.B. Kampman ◽  
Hink Boer ◽  
Coby Meijer ◽  
Gerjan J. Navis ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Renal Function ◽  
Testicular Cancer ◽  
Cancer Survivors ◽  
Disease Risk ◽  
Cardiovascular Disease Risk ◽  
Testicular Cancer Survivors

COMPARISON BETWEEN QUESTIONNAIRES TO LABORATORY FINDINGS IN THE FOLLOW-UP OF TESTICULAR CANCER SURVIVORS

2008 ◽  
Vol 7 (3) ◽  
pp. 86
Author(s):  
J.E. Lackner ◽  
I. Mark ◽  
J. Mauermann ◽  
G. Schatzl ◽  
M. Marberger ◽  
...  
Keyword(s):  
Testicular Cancer ◽  
Cancer Survivors ◽  
Laboratory Findings ◽  
Testicular Cancer Survivors

7172 Feelings of loss and shame after having lost a testicle: a population-based long-term follow-up of testicular-cancer survivors

2009 ◽  
Vol 7 (2) ◽  
pp. 445
Author(s):  
J.S. Skoogh ◽  
G.S. Steineck ◽  
E.C.S. Cavallin-Ståhl ◽  
U.O. Ulrica Olofsson ◽  
M.L. Magnus Lindwall ◽  
...  
Keyword(s):  
Testicular Cancer ◽  
Cancer Survivors ◽  
Population Based ◽  
Long Term Follow Up ◽  
Testicular Cancer Survivors

Detection of second malignancies during long-term follow-up of testicular cancer survivors

Cancer ◽  
2011 ◽  
Vol 117 (18) ◽  
pp. 4212-4218 ◽  
Author(s):  
Tomas Buchler ◽  
Petra Kubankova ◽  
Ludmila Boublikova ◽  
Zuzana Donatova ◽  
Martin Foldyna ◽  
...  
Keyword(s):  
Testicular Cancer ◽  
Cancer Survivors ◽  
Second Malignancies ◽  
Long Term Follow Up ◽  
Testicular Cancer Survivors

P6239Late adverse effects of residual platinum concentrations on cardiac function in testicular cancer survivors: a 30-year follow-up study

2019 ◽  
Vol 40 (Supplement_1) ◽  
Author(s):  
A W Bjerring ◽  
S D Fossa ◽  
H S Haugnes ◽  
K H Haugaa ◽  
T Edvardsen ◽  
...  
Keyword(s):  
Cardiac Function ◽  
Testicular Cancer ◽  
Cancer Survivors ◽  
Longitudinal Strain ◽  
Global Longitudinal Strain ◽  
Intergroup Difference ◽  
Platinum Concentration ◽  
Follow Up Study ◽  
Testicular Cancer Survivors

Abstract Background Cisplatin-based chemotherapy (CBCT) is essential in the treatment of testicular cancer (TC), and platinum can be detected in TC survivors decades after cessation of treatment. CBCT has been implicated as a risk factor in cardiovascular morbidity and mortality. Purpose Our study aimed to assess the relationship between residual serum platinum concentrations and changes in cardiac function and morphology in TC survivors 30 years after CBCT. Methods Seventy TC survivors diagnosed and treated with CBCT (1980–1994) were recruited from the longitudinal Norwegian Cancer Study in Testicular Cancer Survivors. Serum platinum concentration was measured twenty years after CBCT. Patients were then allocated to either a high or low platinum concentration group. Echocardiography was performed in all subjects. Results The participants were on average 60±9 years old. There was a trend towards smaller left ventricular (LV) volumes in the high residual platinum concentration group (Table). No intergroup difference in cardiac function was found. Six (9%) participants had reduced EF (<52%) and 14 (20%) participants had reduced LV global longitudinal strain (> −18.0%), however, there was no intergroup difference. Neither cumulative cisplatin dose nor residual serum platinum concentration showed any correlation with LV or right ventricular functional parameters. Table 1 Low residual Pt concentration >85 ng/L (n=35) High residual Pt concentration <85 ng/L (n=35) p-value Cumulative cisplatin dose, mg/m2 680±249 814±271 <0.05 Residual Pt concentration, ng/L 44±22 136±44 <0.001 3D LV end-diastolic volume, ml/m2 66±17 60±8 0.07 3D LV end-systolic volume, ml/m2 29±15 24±5 0.08 3D ejection fraction, % 57±9 59±6 0.24 LV global longitudinal strain, % −19.2±3.3 −20.0±2.0 0.26 LV global circumferential strain, % −21.1±4.2 −22.1±1.8 0.30 E/e' 10.6±4.4 9.2±2.2 0.10 TAPSE, mm 2.2±0.4 2.3±0.4 0.22 RV fractional area change, % 40±7 41±7 0.67 Data are presented as mean ± SD. The P-values were derived from the Student's t-test. LV, left ventricle; MV, mitral valve; Pt, platinum; RV, right ventricle; TAPSE, tricuspid annular plane systolic excursion. Conclusion Our 30-year follow-up study of testicular cancer patients could not demonstrate impact on cardiac function caused by cumulative cisplatin dose or residual serum platinum concentrations. Acknowledgement/Funding South-Eastern Norway Regional Health Authority

Long-term complications of platinum in testicular cancer survivors

2006 ◽  
Vol 24 (18_suppl) ◽  
pp. 4589-4589
Author(s):  
J. H. Oh ◽  
D. D. Baum ◽  
J. Ensor ◽  
S. Pham ◽  
M. D. Muddiman ◽  
...  
Keyword(s):  
Testicular Cancer ◽  
Cancer Survivors ◽  
Treatment Modalities ◽  
Platinum Based Chemotherapy ◽  
Blood Pressure Treatment ◽  
The Mean ◽  
Testicular Cancer Survivors ◽  
All Treatment

4589 Background: Long-term medical complications of platinum have become a major priority in the care of testicular cancer survivors. This study aimed to describe the prevalence of these complications from platinum-based therapy in American testicular cancer survivors. Methods: Testicular cancer survivors with no evidence of disease for at least 2 years were interviewed, had lab tests, and charts reviewed. Demographics, comorbidities, blood pressure, treatment, and outcomes were compared between all treatment modalities. NHANES 2002 and NHIS 2004 were used to obtain national estimates. Results: The mean age was 41 years; 72.7 % had nonseminoma, 96.5% had orchiectomy, 21.0% received radiation (XRT), and 82.5% platinum. The mean follow-up was 8.4 years. There was no statistical difference in the rates of Coronary Artery Disease (CAD), hyperlipidemia, hypertension (HTN), renal insufficiency (RI), or hypomagnesemia (see table ). There was a trend toward an increase in hyperlipidemia at follow-up compared to initial visit in all treatment groups but HTN increased only in those who did not receive platinum. Conclusion: Excluding HTN, we observed a trend toward an increase in the prevalence of RI, hypomagnesemia, hyperlipidemia, and CAD among patients who received platinum when compared to their baseline rates. Similar to a recent study by Huddart et al, we saw a trend toward higher risk of developing CAD in those who received both platinum and XRT. These findings suggest that hyperlipidemia and HTN may be more related to orchiectomy or the germ cell tumor itself than being a complication of platinum. Further prospective cohort studies with a larger group of survivors who have not received platinum are warranted to determine if HTN and hyperlipidemia are true complications of platinum-based chemotherapy. [Table: see text] No significant financial relationships to disclose.

scholarly journals Psychological Needs Satisfaction, Self-Rated Health and the Mediating Role of Exercise Among Testicular Cancer Survivors

2021 ◽  
Vol 15 (2) ◽  
pp. 155798832110126
Author(s):  
Anika R. Petrella ◽  
Catherine M. Sabiston ◽  
Madison F. Vani ◽  
Andrew Matthew ◽  
Daniel Santa Mina
Keyword(s):  
Mental Health ◽  
Testicular Cancer ◽  
Cancer Survivors ◽  
Psychological Needs ◽  
Basic Psychological Needs ◽  
Exercise Behavior ◽  
Physical And Mental Health ◽  
Self Rated Health ◽  
Needs Satisfaction ◽  
Testicular Cancer Survivors

Exploring tenets of basic psychological needs theory, the objective of this study was to examine the association between psychological needs satisfaction, exercise behavior, and physical and mental health among testicular cancer survivors. The present study investigated whether psychological needs satisfaction was directly associated with increased self-rated health, and if this relationship was mediated by engagement in exercise. Testicular cancer survivors ( N = 135; Mage = 32.45; SD = 7.63) self-reported current psychological needs satisfaction, exercise behavior, and perceived global physical and mental health during routine oncology visits. Associations were examined using path analysis. Psychological needs satisfaction was a positive correlate of both self-rated physical and mental health in this sample, and exercise mediated the association between needs satisfaction and self-rated physical health. This study supports the assumptions underpinning basic psychological needs theory in this unique clinical population. Based on the findings, exercise engagement represents one mechanism associated with perceived health after cancer. Supportive care interventions should aim to enhance satisfaction of psychological needs and investigate exercise as a mechanism underpinning the relationship between needs satisfaction and perceived health in testicular cancer survivors.

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