scholarly journals Recent Advances in Aptamer Discovery and Applications

Molecules ◽  
2019 ◽  
Vol 24 (5) ◽  
pp. 941 ◽  
Author(s):  
Yang Zhang ◽  
Bo Lai ◽  
Mario Juhas
Keyword(s):  
Food Safety ◽  
Real Time ◽  
Basic Research ◽  
Therapeutic Agents ◽  
Clinical Diagnostics ◽  
Future Directions ◽  
Single Stranded Dna ◽  
High Affinity ◽  
Recent Advances ◽  
Real Time Detection

Aptamers are short, single-stranded DNA, RNA, or synthetic XNA molecules that can be developed with high affinity and specificity to interact with any desired targets. They have been widely used in facilitating discoveries in basic research, ensuring food safety and monitoring the environment. Furthermore, aptamers play promising roles as clinical diagnostics and therapeutic agents. This review provides update on the recent advances in this rapidly progressing field of research with particular emphasis on generation of aptamers and their applications in biosensing, biotechnology and medicine. The limitations and future directions of aptamers in target specific delivery and real-time detection are also discussed.

scholarly journals Evolution of Bacterial Tolerance Under Antibiotic Treatment and Its Implications on the Development of Resistance

2021 ◽  
Vol 12 ◽  
Author(s):  
Jordy Evan Sulaiman ◽  
Henry Lam
Keyword(s):  
Acquired Resistance ◽  
Basic Research ◽  
Drug Tolerance ◽  
Clinical Diagnostics ◽  
Future Directions ◽  
Bacterial Populations ◽  
Laboratory Evolution ◽  
Development Of Resistance ◽  
Treatment Conditions ◽  
Comprehensive Knowledge

Recent laboratory evolution studies have shown that upon repetitive antibiotic treatments, bacterial populations will adapt and eventually became tolerant and resistant to the drug. Drug tolerance rapidly evolves upon frequent, intermittent antibiotic treatments, and such emerging drug tolerance seems to be specific to the treatment conditions, complicating clinical practice. Moreover, it has been shown that tolerance often promotes the development of resistance, which further reinforces the need of clinical diagnostics for antibiotic tolerance to reduce the occurrence of acquired resistance. Here, we discuss the laboratory evolution studies that were performed to track the development of tolerance in bacterial populations, and highlight the urgency of developing a comprehensive knowledge base of various tolerance phenotypes and their detection in clinics. Finally, we propose future directions for basic research in this growing field.

scholarly journals Recent advances in fast-scan cyclic voltammetry

The Analyst ◽  
2020 ◽  
Vol 145 (4) ◽  
pp. 1087-1102 ◽  
Author(s):  
Pumidech Puthongkham ◽  
B. Jill Venton
Keyword(s):  
Cyclic Voltammetry ◽  
Real Time ◽  
Fast Scan Cyclic Voltammetry ◽  
Recent Advances ◽  
Future Challenges ◽  
Real Time Detection

We reviewed recent advances and future challenges in fast-scan cyclic voltammetry for real-time detection of neurotransmitters.

Recent advances in epigenomics in NSCLC: real-time detection and therapeutic implications

Epigenomics ◽  
2016 ◽  
Vol 8 (8) ◽  
pp. 1151-1167 ◽  
Author(s):  
Antonello Di Paolo ◽  
Marzia Del Re ◽  
Iacopo Petrini ◽  
Giuseppe Altavilla ◽  
Romano Danesi
Keyword(s):  
Real Time ◽  
Therapeutic Implications ◽  
Recent Advances ◽  
Real Time Detection

Real-Time Detection of Drowsiness Related Lane Departures Using Steering Wheel Angle

2012 ◽  
Author(s):  
Anthony D. McDonald ◽  
Chris Schwarz ◽  
John D. Lee ◽  
Timothy L. Brown
Keyword(s):  
Real Time ◽  
Steering Wheel ◽  
Real Time Detection

Immunotherapy for regional, recurrent and metastatic head and neck cancer: recent advances and future directions

2020 ◽  
pp. 60-69
Author(s):  
Z. A.-G. Radzhabova ◽  
M. Д. Kotov ◽  
A. S. Mitrofanov ◽  
Z. S. Bekyasheva ◽  
E. V. Levchenko
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Future Directions ◽  
Recent Advances
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