Synthesis of Chromen-4-One-Oxadiazole Substituted Analogs as Potent β-Glucuronidase Inhibitors
Keyword(s):
Chromen-4-one substituted oxadiazole analogs 1–19 have been synthesized, characterized and evaluated for β-glucuronidase inhibition. All analogs exhibited a variable degree of β-glucuronidase inhibitory activity with IC50 values ranging in between 0.8 ± 0.1–42.3 ± 0.8 μM when compared with the standard d-saccharic acid 1,4 lactone (IC50 = 48.1 ± 1.2 μM). Structure activity relationship has been established for all compounds. Molecular docking studies were performed to predict the binding interaction of the compounds with the active site of enzyme.
2020 ◽
Vol 1202
◽
pp. 127310
◽
2018 ◽
Vol 26
(12)
◽
pp. 3696-3706
◽
2020 ◽
Vol 16
(3)
◽
pp. 245-256
◽
2015 ◽
Vol 87
(2)
◽
pp. 213-223
◽
2019 ◽
Vol 27
(18)
◽
pp. 4030-4040
◽
2019 ◽
Vol 38
(12)
◽
pp. 3621-3632