scholarly journals General Synthesis of 1-Aryl-6-azaisocytosines and Their Utilization for the Preparation of Related Condensed 1,2,4-Triazines

Molecules ◽  
2019 ◽  
Vol 24 (19) ◽  
pp. 3558 ◽  
Author(s):  
František Zálešák ◽  
Jan Slouka ◽  
Jakub Stýskala
Keyword(s):  
Functional Groups ◽  
Heterocyclic Compounds ◽  
Tautomeric Equilibrium ◽  
Diazonium Salts ◽  
General Synthesis

A simple general synthesis of 1-aryl-6-azaisocytosine-5-carbonitriles 4 is described. This method is based on coupling diazonium salts with cyanoacetylcyanamide 2 and then cyclization of the formed 2-arylhydrazono-2-cyanoacetylcyanamides 3. The 6-azaisocytosines 4 were studied with respect to tautomeric equilibrium and the transformation of functional groups, and used in the synthesis of the condensed heterocyclic compounds: Purine isosteric imidazo[2,1-c]-[1,2,4]triazine 8 and the 1,2,4-triazino[2,3-a]quinazolines 9–12.

Practical Deoxygenation of Oxazole N-Oxides by PCl3/Collidine

Synthesis ◽  
2018 ◽  
Vol 51 (02) ◽  
pp. 414-420
Author(s):  
Valerii Shirinian ◽  
Ilya Lonshakov ◽  
Alexey Zakharov ◽  
Andrey Lvov ◽  
Mikhail Krayushkin
Keyword(s):  
Functional Groups ◽  
Heterocyclic Compounds ◽  
Phosphorus Trichloride ◽  
Double Bonds ◽  
Wide Range

A new chemoselective method for the synthesis of 2-aryl-1,3-oxazoles by deoxygenation of the corresponding N-oxides has been developed. As the deoxygenation reagent, a previously unknown complex of collidine with phosphorus trichloride in a 2:1 ratio has been used. The developed method enabled the preparation of a wide range of 2-aryl-1,3-oxazoles comprising various functional groups in good yields. The advantage of this reagent is its tolerance to nitro, methyl, hydroxyl, formyl, and acetyl groups, and double bonds. Due to chemoselectivity and availability of reagents, the method may be used for deoxygenation of N-oxides of other heterocyclic compounds (thiazole, pyridine, quinoline, etc.).

General synthesis of new rose bengal derivatives with ether functional groups

1987 ◽  
Vol 38 ◽  
pp. 357-363 ◽  
Author(s):  
Danian Xu ◽  
Adriaan Vanloon ◽  
Shwn-Meei Linden ◽  
D.C. Neckers
Keyword(s):  
Functional Groups ◽  
Rose Bengal ◽  
General Synthesis

scholarly journals A General Synthesis of Benzoazepinoindoles – A New Class of Heterocycles

Synlett ◽  
2019 ◽  
Vol 30 (18) ◽  
pp. 2081-2085
Author(s):  
Jeremy C. Dobrowolski ◽  
Duyen H.T. Nguyen ◽  
Benjamin H. Fraser ◽  
Mohan Bhadbhade ◽  
David StC. Black ◽  
...  
Keyword(s):  
Heterocyclic Compounds ◽  
Complex Structures ◽  
New Class ◽  
Rapid Generation ◽  
General Synthesis

A new class of heterocyclic compounds, namely the benzoazepinoindolones, has been synthesised through a base-catalysed cyclisation reaction of 1,4-bis(2-aminophenyl)-2-phenylbutane-1,4-dione derivatives and features the prominent seven-membered azepine ring moiety. This synthesis has considerable scope for the rapid generation of more complex structures and is inexpensive and generally applicable.

REVIEW ON THE SYNTHESIS AND POTENTIAL THERAPEUTIC APPLICATIONS OF HETEROCYCLIC PRODUCTS OF 5-AMINO-3-METHYLISOXAZOLE

2021 ◽  
Vol 12 (08) ◽  
pp. 154-172
Author(s):  
Tahira Saleem ◽  
Muhammad Humble Khalid Tareen ◽  
Muhammad Rashid ◽  
Mehwish Nawaz ◽  
Hina Aftab ◽  
...  
Keyword(s):  
Functional Groups ◽  
Building Block ◽  
Heterocyclic Compounds ◽  
Medicinal Chemistry ◽  
Drug Molecule ◽  
Therapeutic Applications ◽  
Biological Actions

In general, heterocyclic compounds have evoked interest and concern because of their fundamental role in biological profiles and biological actions in nature. Now, most of the lead molecules in medicinal chemistry are based on hetero-atoms. In medicinal chemistry- to bring two hetero-atoms to the drug molecule, isoxazoles are interesting functional groups. Isoxazole as a key building block has been widely used and is an important heterocyclic unit.

Sign in / Sign up

Export Citation Format

Share Document