REVIEW ON THE SYNTHESIS AND POTENTIAL THERAPEUTIC APPLICATIONS OF HETEROCYCLIC PRODUCTS OF 5-AMINO-3-METHYLISOXAZOLE

2021 ◽  
Vol 12 (08) ◽  
pp. 154-172
Author(s):  
Tahira Saleem ◽  
Muhammad Humble Khalid Tareen ◽  
Muhammad Rashid ◽  
Mehwish Nawaz ◽  
Hina Aftab ◽  
...  
Keyword(s):  
Functional Groups ◽  
Building Block ◽  
Heterocyclic Compounds ◽  
Medicinal Chemistry ◽  
Drug Molecule ◽  
Therapeutic Applications ◽  
Biological Actions

In general, heterocyclic compounds have evoked interest and concern because of their fundamental role in biological profiles and biological actions in nature. Now, most of the lead molecules in medicinal chemistry are based on hetero-atoms. In medicinal chemistry- to bring two hetero-atoms to the drug molecule, isoxazoles are interesting functional groups. Isoxazole as a key building block has been widely used and is an important heterocyclic unit.

Chalcones: Retrospective Synthetic Approaches and Mechanistic Aspects of a Privileged Scaffold

2020 ◽  
Vol 26 (24) ◽  
pp. 2843-2858 ◽  
Author(s):  
Emília P.T. Leitão
Keyword(s):  
Pharmacological Activity ◽  
Heterocyclic Compounds ◽  
Medicinal Chemistry ◽  
Therapeutic Applications ◽  
Privileged Scaffold ◽  
Synthetic Methodologies ◽  
Synthetic Approaches

This review summarizes the synthetic methodologies used in the last 25 years for the synthesis of chalcones, which are a class of flavonoids having a 1,3-diphenyl-2-propene-1-one backbone. These compounds are considered a hot topic in the field of medicinal chemistry, due to their pharmacological activity and because they are important precursors for the synthesis of heterocyclic compounds with therapeutic applications such as: flavones, flavanones, isoxazolines, benzothiazepines, pyrimidines and pyrazolines derivatives.

scholarly journals Synthetic Methods of Medicinally Important Heterocycles-thiazines: A Review

2020 ◽  
Vol 14 (1) ◽  
pp. 71-82
Author(s):  
Praveen Kumar Sharma ◽  
Andleeb Amin ◽  
M. Kumar
Keyword(s):  
Heterocyclic Compounds ◽  
Medicinal Chemistry ◽  
Research Community ◽  
Synthetic Methods ◽  
Therapeutic Applications ◽  
Reactive Materials

Heterocyclic compounds containing N and S atoms have unique properties so that they can be used as potential reactive materials in pharmacokinetic systems. In medicinal chemistry, the therapeutic applications of nitrogen sulphur heterocycles are well known. Especially, Thiazines attract the attention of chemists due to their great bioactive behavior. The present study is a review of the work carried out by the research community for the synthesis of novel, effective, medicinally important heterocyclic compounds-thiazines.

The chemistry of 4-(dicyanomethylene)-3-methyl-l-phenyl-2-pyrazoline-5- ones as a privileged scaffold in synthesis of heterocycles

2020 ◽  
Vol 17 ◽  
Author(s):  
Mohsen A.-M. Gomaa ◽  
Huda A. Ali
Keyword(s):  
Building Block ◽  
Heterocyclic Compounds ◽  
Recent Progress ◽  
Reaction Conditions ◽  
Azacrown Ethers ◽  
Wide Range ◽  
Privileged Scaffold ◽  
Number Of Publications ◽  
Near Future

Background : The reactivity of 4-(dicyanomethylene)-3-methyl-l-phenyl-2-pyrazoline-5-one DCNP 1 and its derivatives makes it valuable as a building block for the synthesis of heterocyclic compounds like pyrazolo-imidazoles, - thiazoles, spiropyridines, spiropyrroles, spiropyrans and others. As a number of publications have reported on the reactivity of DCNP and its derivatives, we compiled some features of this interesting molecule. Objective: This article aims to review the preparation of DCNP, its reactivity and application in heterocyclic and dyes synthesis. Conclusion: In this review we have provided an overview of recent progress in the chemistry of DCNP and its significance in synthesis of various classes of heterocyclic compounds and dyes. The unique reactivity of DCNP offers unprecedentedly mild reaction conditions for the generation of versatile cynomethylene dyes from a wide range of precursors including amines, α-aminocarboxylic acids, their esters, phenols, malononitriles and azacrown ethers. We anticipate that more innovative transformations involving DCNP will continue to emerge in the near future.

Recent Advances in Therapeutic Applications of Bisbenzimidazoles

2020 ◽  
Vol 16 (4) ◽  
pp. 454-486 ◽  
Author(s):  
Smita Verma ◽  
Vishnuvardh Ravichandiran ◽  
Nihar Ranjan ◽  
Swaran J.S. Flora
Keyword(s):  
Heterocyclic Compounds ◽  
Wide Spectrum ◽  
Dna Recognition ◽  
Present Review ◽  
Pharmacological Activities ◽  
Structural Motifs ◽  
Therapeutic Applications ◽  
The Past ◽  
Recent Advances

Nitrogen-containing heterocycles are one of the most common structural motifs in approximately 80% of the marketed drugs. Of these, benzimidazoles analogues are known to elicit a wide spectrum of pharmaceutical activities such as anticancer, antibacterial, antiparasitic, antiviral, antifungal as well as chemosensor effect. Based on the benzimidazole core fused heterocyclic compounds, crescent-shaped bisbenzimidazoles were developed which provided an early breakthrough in the sequence-specific DNA recognition. Over the years, a number of functional variations in the bisbenzimidazole core have led to the emergence of their unique properties and established them as versatile ligands against several classes of pathogens. The present review provides an overview of diverse pharmacological activities of the bisbenzimidazole analogues in the past decade with a brief account of its development through the years.

Quinone-Based Drugs: An Important Class of Molecules in Medicinal Chemistry

2020 ◽  
Vol 16 ◽  
Author(s):  
Vitor F. Ferreira ◽  
Alcione S. de Carvalho ◽  
Patricia G. Ferreira ◽  
Carolina G. S. Lima ◽  
Fernando de C. da Silva
Keyword(s):  
Drug Combination ◽  
Medicinal Chemistry ◽  
Pharmaceutical Market ◽  
Important Class ◽  
Therapeutic Applications ◽  
New Applications ◽  
Pharmaceutical Uses

Background: Several quinones are on the pharmaceutical market as drugs for the treatment of several diseases. Objective: The aim of this review was to provide an overview on the quinones that have become drugs for several therapeutic applications. Method: We have comprehensively and critically discussed all the information available in the literature about quinonebased drugs. Results: In this review, the various aspects of the chemistry and biochemistry of these drugs are highlighted, including their repositioning, drug combination and their new uses. Conclusion: The number of studies related to quinone drugs for different pharmaceutical uses shows that the interest in new applications still increasing in recent years.

Recent Development in the Chemistry of Bicyclic 6+5 Systems, Part I: Chemistry of Pyrazolo[3,4-b]pyridines

2019 ◽  
Vol 17 (1) ◽  
pp. 2-23
Author(s):  
Moustafa A. Gouda ◽  
Moged A. Berghot ◽  
Ghada E.A. El Ghani ◽  
Abdel-Galil M. Khalil
Keyword(s):  
Building Block ◽  
Heterocyclic Compounds ◽  
Pharmacological Interest

This review describes the synthesis and reactions of substituted pyrazolo[3,4-b] pyridines as a building block for the synthesis of polyfunctionalized heterocyclic compounds with pharmacological interest.

scholarly journals THE INFLUENCES OF POWER VARIATIONS ON SELECTIVITY OF SYNTHESIS REACTION OF 2’-HYDROXYCHALCONE ANALOGUE UNDER MICROWAVE IRRADIATION

Molekul ◽  
2016 ◽  
Vol 11 (2) ◽  
pp. 299 ◽  
Author(s):  
Adel Zamri ◽  
Hilwan Yuda Teruna ◽  
Ihsan Ikhtiarudin
Keyword(s):  
Drug Discovery ◽  
Microwave Irradiation ◽  
Heterocyclic Compounds ◽  
Medicinal Chemistry ◽  
Synthesis Reaction ◽  
Material Synthesis ◽  
Power Variation ◽  
Material Chemistry ◽  
Irradiation Power

Some 2’-hydroxychalcone analogues have been widely used as an intermediate to synthesize various heterocyclic compounds, such as flavanones, flavanonols, flavones, flavonols and others. The heterocyclic compounds are also known to have a variety of interesting bioactivities in the medicinal chemistry and also have potency to be applied  in material chemistry including in industry. Therefore, 2’-hydroxychalcone analogues are often synthesized by researchers as intermediate, both in research associated with drug discovery and material synthesis. The aim of this study is to investigate the effect of microwave irradiation power variations on the selectivity of reaction of 2’-hydroxychalcone analogue synthesis. The variations of power that have been used in this study were 100, 180, 300 and 450 W with using a domestic microwave. Based on the study, we conclude that the power variation of microwave irradiationwere proven to effect the selectivity of synthesis reaction. In this study, the most suitable irradiation power to be applied on this synthesis is 180 W.

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