Two-Phase Dibromocyclopropanation of Unsaturated Alcohols Using Flow Chemistry
Keyword(s):
Dibromocyclopropanations are conventionally done by addition of dibromocarbene to alkenes under phase-transfer conditions in batch reactions using a strong base (50% NaOH (aq)), vigorous stirring and long reaction times. We have shown that cyclopropanation of unsaturated alcohols can be done under ambient conditions using continuous flow chemistry with 40% (w/w) NaOH (aq) as the base. The reactions were generally rapid; the yields were comparable to yields reported in the literature for the conventional batch reaction
2017 ◽
Vol 7
(3–4)
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pp. 157-158
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2011 ◽
Vol 7
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pp. 1164-1172
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2020 ◽
Vol 24
(10)
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pp. 2260-2265