scholarly journals Design, Synthesis and Bioactive Evaluation of Oxime Derivatives of Dehydrocholic Acid as Anti-Hepatitis B Virus Agents

Molecules ◽  
2020 ◽  
Vol 25 (15) ◽  
pp. 3359
Author(s):  
Zhuocai Wei ◽  
Jie Tan ◽  
Xinhua Cui ◽  
Min Zhou ◽  
Yunhou Huang ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Positive Control ◽  
Docking Studies ◽  
Design Synthesis ◽  
Dehydrocholic Acid ◽  
B Virus ◽  
Effective Inhibition ◽  
Oxime Derivatives ◽  
Derivatives Of

Oxime derivatives of dehydrocholic acid and its esters were designed for anti-hepatitis B virus (HBV) drugs according to principles of assembling active chemical fragments. Twelve compounds were synthesized from dehydrocholic acid by esterification and oxime formation, and their anti-hepatitis B virus (HBV) activities were evaluated with HepG 2.2.15 cells. Results showed that 5 compounds exhibited more effective inhibition of HBeAg than positive control, among them 2b-3 and 2b-1 showed significant anti-HBV activities on inhibiting secretion of HBeAg (IC50 (2b-3) = 49.39 ± 12.78 μM, SI (2b-3) = 11.03; IC50 (2b-1) = 96.64 ± 28.99 μM, SI (2b-1) = 10.35) compared to the Entecavir (IC50 = 161.24 μM, SI = 3.72). Molecular docking studies showed that most of these compounds interacted with protein residues of heparan sulfate proteoglycan (HSPG) in host hepatocyte and bile acid receptor.

Design, Synthesis and Biological Evaluation of Caudatin Analogs as Potent Hepatitis B Virus Inhibitors

2015 ◽  
Vol 11 (2) ◽  
pp. 165-179 ◽  
Author(s):  
Li-Jun Wang ◽  
Hao Chen ◽  
Yun-Bao Ma ◽  
Xiao-Yan Huang ◽  
Chang-An Geng ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Biological Evaluation ◽  
Design Synthesis ◽  
B Virus ◽  
Synthesis And Biological Evaluation

Design, synthesis and evaluation of novel phenyl propionamide derivatives as non-nucleoside hepatitis B virus inhibitors

2018 ◽  
Vol 144 ◽  
pp. 424-434 ◽  
Author(s):  
Jingying Qiu ◽  
Qineng Gong ◽  
Jian Gao ◽  
Wang Chen ◽  
Yinpeng Zhang ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Design Synthesis ◽  
B Virus

Antiviral effects of three novel derivatives of adefovir on the replication of hepatitis B virus

2011 ◽  
Vol 21 (7) ◽  
pp. 1179-1187 ◽  
Author(s):  
Di Wu ◽  
Jun-Qi Niu ◽  
Yan-Hua Ding ◽  
Xin-Yu Wu ◽  
Bo-Hua Zhong ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Antiviral Effects ◽  
B Virus ◽  
Derivatives Of

synthesis of Functionalised derivatives of Pentaerythritol

2003 ◽  
Vol 2003 (1) ◽  
pp. 2-3 ◽  
Author(s):  
E. S. H. El Ashry ◽  
Y. El Kilany ◽  
H. Abdel Hamid ◽  
S. R. El-Zemity ◽  
S. Boghdady
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
B Virus ◽  
Nucleophilic Reagents ◽  
Derivatives Of

The synthesis of functionalised derivatives of pentaerythritol has been attempted by the reaction of 1 with different aldehydes and nucleophilic reagents; the activity of various derivatives against hepatitis B virus has been studied.

Design, synthesis and evaluation of pyrazole derivatives as non-nucleoside hepatitis B virus inhibitors

2016 ◽  
Vol 123 ◽  
pp. 202-210 ◽  
Author(s):  
Haiyong Jia ◽  
Fuxiang Bai ◽  
Na Liu ◽  
Xiaohong Liang ◽  
Peng Zhan ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Pyrazole Derivatives ◽  
Design Synthesis ◽  
B Virus

scholarly journals Design, synthesis, and molecular hybrids of caudatin and cinnamic acids as novel anti-hepatitis B virus agents

2012 ◽  
Vol 54 ◽  
pp. 352-365 ◽  
Author(s):  
Li-Jun Wang ◽  
Chang-An Geng ◽  
Yun-Bao Ma ◽  
Jie Luo ◽  
Xiao-Yan Huang ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Cinnamic Acids ◽  
Design Synthesis ◽  
B Virus ◽  
Molecular Hybrids

scholarly journals Anti-hepatitis B virus activities of purine derivatives of oxetanocin A.

1989 ◽  
Vol 42 (4) ◽  
pp. 644-646 ◽  
Author(s):  
TAKEMITSU NAGAHATA ◽  
KEIJI UEDA ◽  
TOSHIKI TSURIMOTO ◽  
OSAMU CHISAKA ◽  
KENICHI MATSUBARA
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Purine Derivatives ◽  
B Virus ◽  
Derivatives Of
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