Nutraceuticals for Smart Aging and Potential Drug Interactions

Abstract Objectives Alcohol and medication use are increasingly prevalent in the older population. Concurrent use of alcohol and alcohol-interactive (AI) medication can lead to significant adverse consequences. Methods Three reference works were used to create an explicit list of drug substances for which information about the interaction with alcohol was available in at least one of them. Additional information was extracted from the Summary of Product Characteristics (SPC). The first aim was to generate a list of 256 substances with standardized advice regarding the concurrent use of each drug with alcohol. The second aim was to observe the prevalence of potential drug–alcohol-interactions. The list was applied to a database containing information about alcohol and medication use of 1,016 community-dwelling older patients (≥70 years) with polypharmacy. Results About half of the sample population reported to consume alcohol at least once a week. Around 22% were classified as frequent drinkers (5–7 days/week) and 11% as heavier drinkers (>7 units/week). Ninety-three percent alcohol consumers in our sample took at least one chronic drug that potentially interacts with alcohol and 42% used at least one chronic drug for which alcohol use is considered contraindicated. Conclusions We developed an explicit list of potentially drug–alcohol-interactions in older adults, with standardized handling advice. We observed that prevalence of potential drug–alcohol-interactions is substantial in community-dwelling older patients with polypharmacy.

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Potential drug-drug interactions and risk of unplanned hospitalization in older patients with cancer: A survey of the prospective ELCAPA (ELderly CAncer PAtients) cohort

Journal of Geriatric Oncology ◽

10.1016/j.jgo.2019.07.023 ◽

2020 ◽

Vol 11 (4) ◽

pp. 586-592 ◽

Cited By ~ 2

Author(s):

Guillaume Beinse ◽

Delphine Reitter ◽

Lauriane Segaux ◽

Muriel Carvahlo-Verlinde ◽

Benoit Rousseau ◽

...

Keyword(s):

Drug Interactions ◽

Cancer Patients ◽

Older Patients ◽

Potential Drug ◽

Elderly Cancer Patients ◽

Patients With Cancer

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Frequency of potential interactions between drugs in medical prescriptions in a city in southern Brazil

Sao Paulo Medical Journal ◽

10.1590/s1516-31802009000400005 ◽

2009 ◽

Vol 127 (4) ◽

pp. 206-210 ◽

Cited By ~ 7

Author(s):

Genici Weyh Bleich ◽

Ariana Bleich ◽

Priscila Chiamulera ◽

Andréia Cristina Conegero Sanches ◽

Deborah Sandra Leal Guimarães Schneider ◽

...

Keyword(s):

Drug Interactions ◽

High Frequency ◽

Cluster Sampling ◽

Age Group ◽

Pharmaceutical Drugs ◽

Potential Drug ◽

Housing Project ◽

Cross Sectional ◽

Form Part ◽

Potential Interactions

CONTEXT AND OBJECTIVE: Drug interactions form part of current clinical practice and they affect between 3 and 5% of polypharmacy patients. The aim of this study was to identify the frequency of potential drug-drug interactions in prescriptions for adult and elderly patients. TYPE OF STUDY AND SETTING: Cross-sectional pharmacoepidemiological survey in the Parque Verde housing project, municipality of Cascavel, Paraná, Brazil, between December 2006 and February 2007. METHODS: Stratified cluster sampling, proportional to the total number of homes in the housing project, was used. The sample consisted of 95 homes and 96 male or female patients aged 19 or over, with medical prescriptions for at least two pharmaceutical drugs. Interactions were identified using DrugDigest, Medscape and Micromedex softwares. RESULTS: Most of the patients were female (69.8%), married (59.4%) and in the age group of 60 years or over (56.3%), with an income less than or equal to three minimum monthly salaries (81.3%) and less than eight years of schooling (69.8%); 90.6% of the patients were living with another person. The total number of pharmaceutical drugs was 406 (average of 4.2 medications per patient). The drugs most prescribed were antihypertensives (47.5%). The frequency of drug interactions was 66.6%. Among the 154 potential drug interactions, 4.6% were classified as major, 65.6% as moderate and 20.1% as minor. CONCLUSION: The high frequency of drug prescriptions with a potential for differentiated interactions indicates a situation that has so far been little explored, albeit a reality in household surveys.

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Prevalence of alcohol-drug interactions in community-dwelling older patients with polypharmacy

Drug Metabolism and Personalized Therapy ◽

10.1515/dmdi-2020-0183 ◽

2021 ◽

Vol 0 (0) ◽

Author(s):

Santina L. Gorsen ◽

Els Mehuys ◽

Leen De Bolle ◽

Koen Boussery ◽

Eline Tommelein

Keyword(s):

Older Adults ◽

Drug Interactions ◽

Older Patients ◽

Medication Use ◽

Community Dwelling ◽

Sample Population ◽

Potential Drug ◽

Additional Information ◽

Drug Substances ◽

Concurrent Use

Abstract Objectives Alcohol and medication use are increasingly prevalent in the older population. Concurrent use of alcohol and alcohol-interactive (AI) medication can lead to significant adverse consequences. Methods Three reference works were used to create an explicit list of drug substances for which information about the interaction with alcohol was available in at least one of them. Additional information was extracted from the Summary of Product Characteristics (SPC). The first aim was to generate a list of 256 substances with standardized advice regarding the concurrent use of each drug with alcohol. The second aim was to observe the prevalence of potential drug–alcohol-interactions. The list was applied to a database containing information about alcohol and medication use of 1,016 community-dwelling older patients (≥70 years) with polypharmacy. Results About half of the sample population reported to consume alcohol at least once a week. Around 22% were classified as frequent drinkers (5–7 days/week) and 11% as heavier drinkers (>7 units/week). Ninety-three percent alcohol consumers in our sample took at least one chronic drug that potentially interacts with alcohol and 42% used at least one chronic drug for which alcohol use is considered contraindicated. Conclusions We developed an explicit list of potentially drug–alcohol-interactions in older adults, with standardized handling advice. We observed that prevalence of potential drug–alcohol-interactions is substantial in community-dwelling older patients with polypharmacy.

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