scholarly journals Antenatal Determinants of Childhood Obesity in High-Risk Offspring: Protocol for the DiGest Follow-Up Study

Nutrients ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 1156
Author(s):  
Danielle Jones ◽  
Emanuella De Lucia Rolfe ◽  
Kirsten L. Rennie ◽  
Linda M. Oude Griep ◽  
Laura C. Kusinski ◽  
...  

Childhood obesity is an area of intense concern internationally and is influenced by events during antenatal and postnatal life. Although pregnancy complications, such as gestational diabetes and large-for-gestational-age birthweight have been associated with increased obesity risk in offspring, very few successful interventions in pregnancy have been identified. We describe a study protocol to identify if a reduced calorie diet in pregnancy can reduce adiposity in children to 3 years of age. The dietary intervention in gestational diabetes (DiGest) study is a randomised, controlled trial of a reduced calorie diet provided by a whole-diet replacement in pregnant women with gestational diabetes. Women receive a weekly dietbox intervention from enrolment until delivery and are blinded to calorie allocation. This follow-up study will assess associations between a reduced calorie diet in pregnancy with offspring adiposity and maternal weight and glycaemia. Anthropometry will be performed in infants and mothers at 3 months, 1, 2 and 3 years post-birth. Glycaemia will be assessed using bloodspot C-peptide in infants and continuous glucose monitoring with HbA1c in mothers. Data regarding maternal glycaemia in pregnancy, maternal nutrition, infant birthweight, offspring feeding behaviour and milk composition will also be collected. The DiGest follow-up study is expected to take 5 years, with recruitment finishing in 2026.

2016 ◽  
Vol 15 (1) ◽  
Author(s):  
Tove Lekva ◽  
Annika Elisabeth Michelsen ◽  
Jens Bollerslev ◽  
Errol R. Norwitz ◽  
Pål Aukrust ◽  
...  

Nutrients ◽  
2020 ◽  
Vol 12 (4) ◽  
pp. 1165
Author(s):  
Laura C. Kusinski ◽  
Helen R. Murphy ◽  
Emanuella De Lucia Rolfe ◽  
Kirsten L. Rennie ◽  
Linda M. Oude Griep ◽  
...  

Gestational diabetes mellitus (GDM) annually affects 35,000 pregnancies in the United Kingdom, causing suboptimal health outcomes to the mother and child. Obesity and excessive gestational weight gain are risk factors for GDM. The Institute of Medicine recommends weight targets for women that are overweight and obese, however, there are no clear guidelines for women with GDM. Observational data suggest that modest weight loss (0.6–2 kg) after 28 weeks may reduce risk of caesarean section, large-for-gestational-age (LGA), and maternal postnatal glycaemia. This protocol for a multicentre randomised double-blind controlled trial aims to identify if a fully controlled reduced energy diet in GDM pregnancy improves infant birthweight and reduces maternal weight gain (primary outcomes). A total of 500 women with GDM (National Institute of Health and Care Excellence (NICE) 2015 criteria) and body mass index (BMI) ≥25 kg/m2 will be randomised to receive a standard (2000 kcal/day) or reduced energy (1200 kcal/day) diet box containing all meals and snacks from 28 weeks to delivery. Women and caregivers will be blinded to the allocations. Food diaries, continuous glucose monitoring, and anthropometry will measure dietary compliance, glucose levels, and weight changes. Women will receive standard antenatal GDM management (insulin/metformin) according to NICE guidelines. The secondary endpoints include caesarean section rates, LGA, and maternal postnatal glucose concentrations.


BioMedicine ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. 24-29
Author(s):  
Saloumeh Peivandi ◽  
Ali Habibi ◽  
Seyed Hamzeh Hosseini ◽  
Mohammad Khademloo ◽  
Mohammad Raisian ◽  
...  

1984 ◽  
Vol 63 (s118) ◽  
pp. 103-106 ◽  
Author(s):  
N. W. Svenningsen ◽  
H. Liedholm ◽  
A. Åberg

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