Effect of Different Direct Compaction Grades of Mannitol on the Storage Stability of Tablet Properties Investigated Using a Kohonen Self-Organizing Map and Elastic Net Regression Model

This study tested 15 direct compaction grades to identify the contribution of different grades of mannitol to the storage stability of the resulting tablets. After preparing the model tablets with different values of hardness, they were stored at 25 °C, 75% relative humidity for 1 week. Then, measurement of the tablet properties was conducted on both pre- and post-storage tablets. The tablet properties were tensile strength (TS), friability, and disintegration time (DT). The experimental data were analyzed using a Kohonen self-organizing map (SOM). The SOM analysis successfully classified the test grades into three distinct clusters having different changes in the behavior of the tablet properties accompanying storage. Cluster 1 showed an obvious rise in DT induced by storage, while cluster 3 showed a substantial change in mechanical strength of the tablet including a reduction in the TS and a rise in friability. Furthermore, the data were analyzed using an Elastic net regression technique to investigate the general relationships between the powder properties of mannitol and the change behavior of the tablet properties. Consequently, we succeeded in identifying the crucial powder properties for the storage stability of the resulting tablets. This study provides advanced technical knowledge to characterize the effect of different direct compaction grades of mannitol on the storage stability of tablet properties.

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Characterization of Powder- and Tablet Properties of Different Direct Compaction Grades of Mannitol Using a Kohonen Self-organizing Map and a Lasso Regression Model

Journal of Pharmaceutical Sciences ◽

10.1016/j.xphs.2020.05.010 ◽

2020 ◽

Vol 109 (8) ◽

pp. 2585-2593

Author(s):

Atsushi Kosugi ◽

Kok Hoong Leong ◽

Hinako Tsuji ◽

Yoshihiro Hayashi ◽

Shungo Kumada ◽

...

Keyword(s):

Regression Model ◽

Self Organizing Map ◽

Lasso Regression ◽

Tablet Properties ◽

Self Organizing

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Utilization of Cellulose from Luffa cylindrica Fiber as Binder in Acetaminophen Tablets

Advances in Environmental Chemistry ◽

10.1155/2015/243785 ◽

2015 ◽

Vol 2015 ◽

pp. 1-8 ◽

Cited By ~ 4

Author(s):

John Carlo O. Macuja ◽

Laurence N. Ruedas ◽

Rebecca C. Nueva España

Keyword(s):

Luffa Cylindrica ◽

Compression Process ◽

Disintegration Time ◽

Pharmaceutical Excipient ◽

Significant Difference ◽

Percentage Yield ◽

Tablet Properties ◽

Powder Properties ◽

The Mean ◽

Tablet Hardness

Cellulose is an important pharmaceutical excipient. This study aimed to produce cellulose from the fiber of Luffa cylindrica as an effective binder in the formulation of acetaminophen tablets. This study was divided into three phases, namely, (I) preparation of cellulose from Luffa cylindrica, (II) determination of the powder properties of the LC-cellulose, and (III) production and evaluation of acetaminophen of the tablets produced using LC-cellulose as binder. The percentage yield of LC-cellulose was 61%. The values of the powder properties of LC-cellulose produced show fair and passable flow properties and are within the specifications of a powdered pharmaceutical excipient. The mean tablet hardness and disintegration time of the LC-cellulose tablets have a significant difference in the mean tablet hardness and disintegration time of the tablets without binder; thus the cellulose produced improved the suitability of acetaminophen in the dry compression process. However, the tablet properties of the tablets produced using LC-cellulose as binder do not conform to the specifications of the US pharmacopeia; thus the study of additional methods and excipients is recommended.

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