scholarly journals Study on the Complexation and Release Mechanism of Methylphenidate Hydrochloride Ion Exchange Resin Complex

Polymers ◽  
2021 ◽  
Vol 13 (24) ◽  
pp. 4394
Author(s):  
Conghui Li ◽  
Xiaolu Han ◽  
Xiaoxuan Hong ◽  
Xianfu Li ◽  
Hui Zhang ◽  
...  
Keyword(s):  
Ion Exchange ◽  
Exchange Resin ◽  
Drug Loading ◽  
Model Fitting ◽  
Ion Exchange Resin ◽  
Dynamics Simulation ◽  
Taste Masking ◽  
Release Mechanism ◽  
Salt Bridges ◽  
Factors Affecting

Since the advent of ion exchange resin, it has been widely used in many fields, including drug delivery systems. The drug binds to the resin through an exchange reaction to form a drug–resin complex, which can gradually release drugs through the exchange of physiological ions in the gastrointestinal tract, to realize functions such as taste masking and regulating release. In this study, the complexes of methylphenidate hydrochloride and Amberlite IRP69 were prepared and evaluated to explore the mechanism of complexation, influencing factors and release mechanism at a molecular level. Firstly, with the properties of the selected complexes, molecular dynamics simulation was innovatively used to find that the intermolecular interaction between drug molecules and ion exchange resin molecules is mainly caused by the stacking effect of π and salt bridges. Secondly, with the drug loading status as an indicator, the factors affecting the compounding process of the drug and resin were explored. Finally, the release mechanism of the drug–resin complex was studied by mathematical model fitting. In summary, a variety of methods were used to study the mechanism of complexation and release between drug and resin, providing a theoretical basis for promoting the marketing of ion−exchange resin−mediated oral preparations.

Hot melt extrusion of ion-exchange resin for taste masking

2018 ◽  
Vol 547 (1-2) ◽  
pp. 385-394 ◽  
Author(s):  
David Cheng Thiam Tan ◽  
Jeremy Jianming Ong ◽  
Rajeev Gokhale ◽  
Paul Wan Sia Heng
Keyword(s):  
Ion Exchange ◽  
Exchange Resin ◽  
Hot Melt Extrusion ◽  
Ion Exchange Resin ◽  
Taste Masking ◽  
Melt Extrusion ◽  
Hot Melt

Improvement of drug loading onto ion exchange resin by cyclodextrin inclusion complex

2012 ◽  
Vol 39 (11) ◽  
pp. 1672-1680 ◽  
Author(s):  
Wipada Samprasit ◽  
Theerasak Rojanarata ◽  
Prasert Akkaramongkolporn ◽  
Tanasait Ngawhirunpat ◽  
Warisada Sila-on ◽  
...  
Keyword(s):  
Ion Exchange ◽  
Inclusion Complex ◽  
Exchange Resin ◽  
Drug Loading ◽  
Ion Exchange Resin ◽  
Cyclodextrin Inclusion ◽  
Cyclodextrin Inclusion Complex

Taste masking of Etoricoxib by using ion-exchange resin

2009 ◽  
Vol 15 (5) ◽  
pp. 511-517 ◽  
Author(s):  
Sradhanjali Patra ◽  
Rakesh Samantaray ◽  
Saswat Pattnaik ◽  
B. B. Barik
Keyword(s):  
Ion Exchange ◽  
Exchange Resin ◽  
Ion Exchange Resin ◽  
Taste Masking

scholarly journals Preparation and characterization of taste masked valsartan by ion-exchange resin approach

2018 ◽  
pp. 11-25
Keyword(s):  
Complex Formation ◽  
Ion Exchange ◽  
Bitter Taste ◽  
Exchange Resin ◽  
Mixing Time ◽  
Spectroscopic Method ◽  
Ion Exchange Resin ◽  
Drug Formulation ◽  
Taste Masking ◽  
Scanning Calorimetry

The bitter taste is one of the most important drug formulation problems. The unpleasant taste leads to noncompliance, which consequently decreases the therapeutic efficacy of the drug. Therefore, masking of bitter taste is very important in drug formulation. In this study an antihypertensive drug, valsartan, which is a weak acid with bitter taste, was used as a model drug to mask its taste with dowex2 (weak base anion exchange resin). The taste masking of a drug using ion exchange resin basically depends on the complex formation between the drug and a specific type of resin. Complex formation under various preparation conditions including; the ratio of drug to resin, mixing time, the pH of the processing medium and the concentration of valsartan was investigated in this study. Optimum conditions for complex formation and maximum drug load were obtained at a drug-resin ratio 1:8, mixing time 4 hours, pH 6.8, temperature 50º C and drug concentration 0.02% w/v. The drug resin ate complex was evaluated for the drug content, taste, drug release and molecular properties. The resinate formation was confirmed using different analytical techniques like thermal analysis using differential scanning calorimetry (DSC), spectroscopic method like Fourier transform infrared spectroscopy (FTIR) and by X-ray powder diffraction analysis (XRPD).

Preparation and characterization of taste masked valsartan by ion-exchange resin approach

10.32947/358 ◽  
2018 ◽  
Vol 18 (1) ◽  
pp. 11-25
Keyword(s):  
Complex Formation ◽  
Ion Exchange ◽  
Bitter Taste ◽  
Exchange Resin ◽  
Mixing Time ◽  
Spectroscopic Method ◽  
Ion Exchange Resin ◽  
Drug Formulation ◽  
Taste Masking ◽  
Scanning Calorimetry

The bitter taste is one of the most important drug formulation problems. The unpleasant taste leads to noncompliance, which consequently decreases the therapeutic efficacy of the drug. Therefore, masking of bitter taste is very important in drug formulation. In this study an antihypertensive drug, valsartan, which is a weak acid with bitter taste, was used as a model drug to mask its taste with dowex2 (weak base anion exchange resin). The taste masking of a drug using ion exchange resin basically depends on the complex formation between the drug and a specific type of resin. Complex formation under various preparation conditions including; the ratio of drug to resin, mixing time, the pH of the processing medium and the concentration of valsartan was investigated in this study. Optimum conditions for complex formation and maximum drug load were obtained at a drug-resin ratio 1:8, mixing time 4 hours, pH 6.8, temperature 50º C and drug concentration 0.02% w/v. The drug resin ate complex was evaluated for the drug content, taste, drug release and molecular properties. The resinate formation was confirmed using different analytical techniques like thermal analysis using differential scanning calorimetry (DSC), spectroscopic method like Fourier transform infrared spectroscopy (FTIR) and by X-ray powder diffraction analysis (XRPD).

CO2 desorption kinetics for waste ion-exchange resin-based activated carbon by model-fitting and model-free

2017 ◽  
Vol 655 ◽  
pp. 52-62 ◽  
Author(s):  
Mengqi Wei ◽  
Qingbo Yu ◽  
Wenjun Duan ◽  
Fan Yang ◽  
Tianwei Wu ◽  
...  
Keyword(s):  
Activated Carbon ◽  
Ion Exchange ◽  
Exchange Resin ◽  
Model Fitting ◽  
Ion Exchange Resin ◽  
Desorption Kinetics ◽  
Model Free ◽  
Co2 Desorption

scholarly journals DESIGN AND OPTIMIZATION OF PEDIATRIC CEFUROXIME AXETIL DISPERSIBLE TABLET CONTAINING ION-EXCHANGE RESIN

2019 ◽  
pp. 325-332
Author(s):  
NISHANT OZA ◽  
SWATI SAGAR
Keyword(s):  
Ion Exchange ◽  
Drug Release ◽  
Factorial Design ◽  
Exchange Resin ◽  
Ion Exchange Resin ◽  
Cefuroxime Axetil ◽  
Full Factorial Design ◽  
Taste Masking ◽  
Dispersible Tablet ◽  
Full Factorial

Objective: The aim of present work was to develop of pediatric cefuroxime axetil 125 mg dispersible tablets by using ion exchange resin as a taste masking agent and quality target product profile was defined based on the properties of the cefuroxime axetil. Methods: Initially, cefuroxime axetil and various resin complexes (DRC) were prepared with different conditions and evaluated for taste masking and drug loading. Optimized DRC was used to formulate the dispersible tablet. A 32 full factorial design was employed to study the effect of mannitol (X1) and microcrystalline cellulose PH-101 (X2) on drug release at 10 min and time taken to 80% drug release. In the present study, the following constraints were arbitrarily used for the selection of an optimized batch: Q10>65% and T80%<30 min. Multiple linear regression analysis, ANOVA and graphical representation of the influence factor by 3D plots were performed by using Sigmaplot 11.0. Checkpoint batch was prepared to validate the evolved model. Results: Among the various drug resins complex DRC-9 was found with less bitter taste which was containing kyron T-114 and among the all factorial batch F7 showed highest drug release at 10 min (Q10) and lowest time taken to 80% drug release (T80) hence batch F7 was selected as an optimized batch and it’s found to be stable in the stability evaluation. Conclusion: The results of full factorial design indicate mannitol and MCC PH-101 have a significant effect on drug release.

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