dispersible tablet
Recently Published Documents


TOTAL DOCUMENTS

78
(FIVE YEARS 39)

H-INDEX

7
(FIVE YEARS 2)

2021 ◽  
Vol 8 (12) ◽  
pp. 530-534
Author(s):  
Ketki Jandial ◽  
Shagufta Tabassum

Background: Postoperative sore throat (POST) is considered to be quite common complaint. Its symptoms tend to improve with time, but use of oral zinc lozenge has been shown to reduce the incidence and severity of POST. The aim of the present study was to find the efficacy of oral zinc sulfate, given 30 min preoperatively, in reducing POST, primarily caused by endotracheal intubation, till 24 hours after surgery. Method: A prospective, randomized, double-blinded, placebo-control-trial study was conducted on 80 patients, further divided into two groups of 40 patients each, between the age group of 18-60 years, of either gender, in Super Specialty Hospital, GMC Jammu, over a period of 6-months. The two groups received either dispersible zinc tablet or a placebo. The severity of POST was graded on a 4-point scale ranging from 0 to 3 and evaluation was repeated at 30 min, 2, 4, and 24 hour, postoperatively. Results: The difference in severity of sore throat was found to be statistically significant at all evaluation time intervals, except at 24 hours, which was quite lower in Zinc group. The overall incidence of POST in Zinc group was 26.3%, which was significantly higher at 50% in placebo group. Conclusion: A dose 40 mg zinc dispersible tablet, equivalent to 40 mg elemental zinc, given 30 min before surgery, effectively reduced the incidence and severity of POST. Keywords: Post Operative Sore Throat, Oral Zinc Lozenge, Endotracheal Intubation.


2021 ◽  
Vol 0 (0) ◽  
pp. 0-0
Author(s):  
Onur Pınarbaşlı ◽  
Burcu Bulut ◽  
Gülistan Pelin Gurbetoğlu ◽  
Nurdan Atılgan ◽  
Nagehan Sarraçoğlu ◽  
...  

Nutrients ◽  
2021 ◽  
Vol 13 (10) ◽  
pp. 3516
Author(s):  
Thomas Hayman ◽  
Peter Hickey ◽  
Daniela Amann-Zalcenstein ◽  
Cavan Bennett ◽  
Ricardo Ataide ◽  
...  

Preventive zinc supplementation provided as a stand-alone dispersible tablet, or via home fortification as multiple micronutrient powders (MNPs), has been considered a potential strategy to prevent zinc deficiency and improve health (including immune) outcomes among children in low- and middle-income countries. However, the impact of zinc supplementation on immune profiles has not been well characterized. We sought to define the effect of zinc supplementation on peripheral blood gene expression and cytokine levels among young children in Dhaka, Bangladesh. In a sub-study of a large randomized, controlled, community-based efficacy trial where children 9-11 months of age received one of the following interventions on a daily basis for 24 weeks: (1) MNPs containing 10 mg of zinc; (2) dispersible tablet containing 10 mg zinc; or (3) placebo powder, we used RNA sequencing to profile the peripheral blood gene expression, as well as highly sensitive multiplex assays to detect cytokine profiles. We profiled samples from 100 children enrolled in the parent trial (zinc MNPs 28, zinc tablets 39, placebo 33). We did not detect an effect from either zinc intervention on differential peripheral blood gene expression at the end of the intervention, or an effect from the intervention on changes in gene expression from baseline. We also did not detect an effect from either intervention on cytokine concentrations. Exploratory analysis did not identify an association between undernutrition (defined as stunting, underweight or wasting) and peripheral blood gene expression. Zinc interventions in children did not produce a gene expression or cytokine signature in the peripheral blood. However, this study demonstrates a proof of principle that sensitive multi-omic techniques can be applied to samples collected in field studies.


Author(s):  
Abhishek Kumar Thakur ◽  
Naveen Gupta ◽  
Dharmendra Singh Rajput ◽  
Neeraj Sharma

This Present research with dispersible tablet can compromise the efficacy and safety of the treatment to children’s and geriatric patients with masking the bitter taste of drug and developing its dispersible tablet. The purpose of this research work was to develop Dispersible tablet of Ornidazole by masking the bitter taste. Tablet containing drug and excipients were prepared by direct compression method. Excipients in combinations were incorporated to achieve the aim. Effect of different combinations was studied to optimize the ideal formulation. Drug excipients interaction studies were carried out by FTIR spectral analysis. The tablets were evaluated for their hardness, wetting time, disintegrating time and dissolution parameters. It was concluded that the tablets having the combination of Dried Mucilage (obtained from dried seeds of ocimum bacilicum) and Sodium starch glycolate met all the evaluation parameters and thus selected as the optimized formulation. Optimized formulation was undergone for stability testing as a parameter to predict the shelf life as per ICH guidelines and proved for its adequate shelf life.


2021 ◽  
Author(s):  
Javier Suárez González ◽  
Ana Santoveña Estévez ◽  
Mabel Soriano ◽  
Jose Bruno Fariña

Background: In 2020 the composition and procedure to elaborate a new formulation containing Isoniazid, Pyrazinamide and Rifampicin to treat tuberculosis in pediatric patients was published. The temperature and relative humidity in Tuberculosis-endemic countries are high, > 30ºC and > 70% respectively and thus these meteorological conditions required a new dosage form. The objective of this work is to register changes in tablet quality and stability over time when exposed to different storage conditions according to ICH. Method: Tablets were subjected to accelerated, long term and low relative humidity conditions. The effect of light was also tested. Quality was measured by evaluating weight changes tensile strength, disintegration time, and drug content. Hydrazine formation was also evaluated as it is considered a mutagenic degradation product. Results: Tablets stored at low relative humidity showed the best stability. There was no statistically significant difference between tablets exposed to or protected from light. Moreover, the formation of Hydrazine was not detected during stability studies. Conclusion: This new dosage form for treating Tuberculosis is stable and able to maintain its quality when appropriate storage conditions are used.


2021 ◽  
pp. 36-38
Author(s):  
Purnima Rai ◽  
Braj Nandan Kishor ◽  
Pooja Pradhan

In this postulations we think about Surface Solid Dispersion and Oro dispersible tablet for upgrade of disintegration rate of valsartan. The medications having low solvency, the disintegration of these medications is rate constraining advance in their bioavailability in oral measurements frames. To defeat this number of innovations are accessible. Among them surface solid dispersion and oro dispersible tablets are two promising systems. Surface solid dispersion is a method for scattering at least one xing on a water solvent transporter of to a great degree high surface territory to accomplish expanded bioavailability and disintegration rates of insoluble medications, and oro dispersible tablets are one of the novel oral medication conveyance framework that break down or scatter rapidly in almost no time after situation in month without water.


Author(s):  
Mayuri Konda ◽  
Kukkdapu Pavan Kumar ◽  
Neela Swapna ◽  
Chinnala Krishna Mohan

In human anatomy mouth is the earliest segment of alimentary canal which receives food and fabricates saliva, and is one of the foundation for bacterial development due to accretion of sugars form food chunks. There have been more than 300 kinds of bacteria set up in the mouth. The purpose of the present study is to investigate the number of microbes’ grown-up at different timings of the day by collecting the samples from individual volunteer oral cavities and counting the colonies; the utmost count was noted as in the range of 190-200 in the evening samples. The same samples were used to calculate minimum inhibitory concentration of Triclosan, the antibiotic formulated for oral hygiene. Triclosan dilutions were prepared and analyzed for the inhibition zones, it resulted that 300mg of the drug have shown satisfactory results. Triclosan was formulated into a dispersible tablet to enable dispersion of tablet into water for rinsing the oral cavity to remove the contaminants. The Dispersion time of the tablet was within the range of 43.66-111.33 second and it was observed that formulation was acceptable with reasonable limits of standard required for dispersible tablets. Addition of superdisintegrant enhanced the dispersion time which facilitates easy mixing of tablet in water. It concludes that superdisintegrant addition technique is a useful method for preparing dispersible tablets by wet granulation method, and Triclosan dispersible tablet further reduces the microbial attack on tooth by rinsing each time after meals, upon doing so on long term basis the dental decays will probably be eradicated.


Author(s):  
Beena P ◽  
Arun G Krishnan ◽  
Nisha Ullas ◽  
Chippy S Pillai ◽  
Sam C Mathew ◽  
...  

The aim of present work is to prepare the orally dissolving tablets of poorly soluble Ondransetron Hydrochloride as its soluble form by adopting complexation method using different superdisintegrants alone and in combination. The growing importance of orally dissolving tablet was underlined recently when European Pharmacopoeia adopted the term “Oro dispersible tablet” as a tablet that to be placed in the mouth where it disperses rapidly before swallowing. Their characteristic advantages such as administration without water anywhere, anytime lead to their suitability to geriatric and paediatric patients. The complex prepared was showed better solubility in simulated salivary PH of 6.8. The pre compression characteristics of drug, drug with Beta cyclodextrin and final blend were evaluated with respect to standards. Results of the study showed that the optimized tablet with combination of superdisintegrants (2.5% crosspovidone, 3.5% sodium starch glycolate) showed hardness of 3.5Kg/Cm2, thickness 2.10mm, wetting time 18 sec, drug content 99.15%, disintegration time 20sec, in-vitro dispersion time 25sec, in-vitro drug release of 89.59% (in 3min) and percentage of drug permeation as 89.45% (in 5 min) and it is comparable with higher percentage of superdisintegrants used for tablet preparation. So this method was a promising approach for developing cost effective dosage form with high efficacy in treatment.


2021 ◽  
Vol 10 (2) ◽  
pp. 71-80
Author(s):  
Shrestha Prabhat ◽  
Shrestha Rajan ◽  
Shrestha Sahana

Objective: This study aims to prepare the taste-masked granules of Mirtazapine by mass extrusion technique and formulate it into an oral dispersible tablet using different super disintegrates. Methods: Taste masked granules of mirtazapine were prepared by mass extrusion technique using Eudragit EPO in different ratios. The drug-polymer ratio was optimized based on the percent drug release in SSF and SGF. Taste masking efficacy of drug-polymer complex was determined by developing the bitterness threshold value of Mirtazapine. The selected drug-polymer complex was formulated into an oro-dispersible tablet by direct compression method. A randomized design was used to investigate individual effect of three different super disintegrates each in different concentrations. Ten formulations were developed including a controlled formulation without the addition of superdisintegrants. A comparative study was done based on various pre-compression and post-compression parameters. Results: Eudragit EPO was able to mask the bitter taste of Mirtazapine effectively in 1:2 ratio by mass extrusion method. The minimum disintegration time and wetting time was found to be 13.6±2.7 and 18.13±0.24 seconds with the formulation containing crospovidone 5% (F9). It was found that the wetting time and disintegration time followed the order SSG>CCS>CPV. The selected best formulation was subjected to an incompatibility study design. The IR spectrum showed that all the excipients were chemically compatible. Conclusion: Thus, in this study unpalatable taste of Mirtazapine was masked using Eudragit EPO polymer by mass extrusion technique, and superdisintegrants were added to prepare orally disintegrating tablets of Mirtazapine. This research work suggests a rapid, simple and cost effective method for formulating Mirtazapine ODT.


Sign in / Sign up

Export Citation Format

Share Document