The Role of 2-[18F]-FDG PET/CT in Detecting Richter Transformation in Chronic Lymphocytic Leukemia: A Systematic Review

Richter transformation (RT) is a condition wherein B cell chronic lymphocytic leukemia (CLL) transforms into a more aggressive lymphoma variant. The incidence and the significance of RT detected by 2-[18F]-FDG PET/CT is a clinical challenge and it is not widely investigated in the literature. The aim of this systematic review was to analyze published data about the potential role of 2-[18F]-FDG PET/CT in detecting RT. A comprehensive computer literature search of the PubMed/MEDLINE, Embase and Cochrane library databases was conducted up to December 2020. Thirteen studies (1336 patients with CLL) were selected. The maximum standardized uptake value (SUVmax) was the most common metabolic parameter used to detect RT. An SUVmax of 5 had an average overall sensitivity of 87% (range: 71–96%), an average overall specificity of 49% (range: 4–80%), an average positive predictive value of 41% (range: 16–53%) and an average negative predictive value of 84% (range: 33–97%). Other metabolic variables were only marginally investigated, with promising results. 2-[18F]-FDG PET/CT imaging may play an important role in the detection of RT in CLL, based on the high metabolic activity of the nodal lesions that transformed into aggressive lymphomas. 2-[18F]-FDG PET/CT has high negative predictive value for evaluating RT.

Download Full-text

Role of 18F-FDG PET-CT for evaluating the response to reduced-intensity conditioning allogeneic transplant in heavily pre-treated patients with chronic lymphocytic leukemia: preliminary results in nine patients

Annals of Nuclear Medicine ◽

10.1007/s12149-012-0639-7 ◽

2012 ◽

Vol 26 (9) ◽

pp. 764-768

Author(s):

Silvia Taralli ◽

Maria Lucia Calcagni ◽

Vittoria Rufini ◽

Luca Laurenti ◽

Simona Sica ◽

...

Keyword(s):

Chronic Lymphocytic Leukemia ◽

Fdg Pet ◽

Lymphocytic Leukemia ◽

Allogeneic Transplant ◽

Reduced Intensity Conditioning ◽

Pet Ct ◽

18F Fdg ◽

Fdg Pet Ct ◽

Reduced Intensity

Download Full-text

A systematic review about the role of preoperative 18F-FDG PET/CT for prognosis and risk stratification in patients with endometrial cancer

Revista Española de Medicina Nuclear e Imagen Molecular (English Edition) ◽

10.1016/j.remnie.2021.05.009 ◽

2021 ◽

Author(s):

Edel Noriega-Álvarez ◽

Ana M. García Vicente ◽

Germán A. Jiménez Londoño ◽

Wilson R. Martínez Bravo ◽

Beatriz González García ◽

...

Keyword(s):

Systematic Review ◽

Endometrial Cancer ◽

Risk Stratification ◽

Fdg Pet ◽

Pet Ct ◽

18F Fdg ◽

Fdg Pet Ct

Download Full-text

Role of 18F-FDG PET/CT in detection of hematogenous metastases of advanced differentiated thyroid carcinoma: a systematic review and meta-analysis

10.20517/2394-4722.2020.118 ◽

2021 ◽

Author(s):

Natale Quartuccio ◽

Domenico Rubello

Keyword(s):

Systematic Review ◽

Thyroid Carcinoma ◽

Fdg Pet ◽

Meta Analysis ◽

Differentiated Thyroid Carcinoma ◽

Pet Ct ◽

18F Fdg ◽

Fdg Pet Ct

Download Full-text

The role of diffusion-weighted MRI and 18F-FDG PET/CT in the prediction of pathologic complete response after radiochemotherapy for rectal cancer: A systematic review

Radiotherapy and Oncology ◽

10.1016/j.radonc.2014.11.026 ◽

2014 ◽

Vol 113 (2) ◽

pp. 158-165 ◽

Cited By ~ 101

Author(s):

Ines Joye ◽

Christophe M. Deroose ◽

Vincent Vandecaveye ◽

Karin Haustermans

Keyword(s):

Systematic Review ◽

Rectal Cancer ◽

Fdg Pet ◽

Pathologic Complete Response ◽

Complete Response ◽

Diffusion Weighted Mri ◽

Pet Ct ◽

18F Fdg ◽

Fdg Pet Ct

Download Full-text

2-[18F]-FDG PET/CT Role in Detecting Richter Transformation of Chronic Lymphocytic Leukemia and Predicting Overall Survival

Clinical Lymphoma Myeloma & Leukemia ◽

10.1016/j.clml.2020.12.003 ◽

2020 ◽

Author(s):

Domenico Albano ◽

Luca Camoni ◽

Carlo Rodella ◽

Raffaele Giubbini ◽

Francesco Bertagna

Keyword(s):

Overall Survival ◽

Chronic Lymphocytic Leukemia ◽

Fdg Pet ◽

Lymphocytic Leukemia ◽

Pet Ct ◽

18F Fdg ◽

Fdg Pet Ct

Download Full-text

Role of 2-[18F]FDG as a Radiopharmaceutical for PET/CT in Patients with COVID-19: A Systematic Review

Pharmaceuticals ◽

10.3390/ph13110377 ◽

2020 ◽

Vol 13 (11) ◽

pp. 377

Author(s):

Salvatore Annunziata ◽

Roberto C. Delgado Bolton ◽

Christel-Hermann Kamani ◽

John O. Prior ◽

Domenico Albano ◽

...

Keyword(s):

Systematic Review ◽

Positron Emission Tomography ◽

Fdg Pet ◽

Emission Tomography ◽

Evidence Based ◽

Positron Emission ◽

Pet Ct ◽

18F Fdg ◽

Fdg Pet Ct

Some recent studies evaluated the role of fluorine-18 fluorodeoxyglucose (2-[18F]FDG) as a radiopharmaceutical for positron emission tomography/computed tomography (PET/CT) imaging in patients with Coronavirus Disease (COVID-19). This article aims to perform a systematic review in this setting. A comprehensive computer literature search in PubMed/MEDLINE and Cochrane library databases regarding the role of 2-[18F]FDG PET/CT in patients with COVID-19 was carried out. This combination of key words was used: (A) “PET” OR “positron emission tomography” AND (B) “COVID” OR “SARS”. Only pertinent original articles were selected; case reports and very small case series were excluded. We have selected 11 original studies of 2-[18F]FDG PET/CT in patients with COVID-19. Evidence-based data showed first preliminary applications of this diagnostic tool in this clinical setting, with particular regard to the incidental detection of interstitial pneumonia suspected for COVID-19. To date, according to evidence-based data, 2-[18F]FDG PET/CT cannot substitute or integrate high-resolution CT to diagnose suspicious COVID-19 or for disease monitoring, but it can only be useful to incidentally detect suspicious COVID-19 lesions in patients performing this imaging method for standard oncological and non-oncological indications. Published data about the possible role of 2-[18F]FDG PET/CT in patients with COVID-19 are increasing, but larger studies are warranted.

Download Full-text

The Role of 18F-FDG PET/CT in Staging and Prognostication of Mantle Cell Lymphoma: An Italian Multicentric Study

Cancers ◽

10.3390/cancers11121831 ◽

2019 ◽

Vol 11 (12) ◽

pp. 1831 ◽

Cited By ~ 4

Author(s):

Domenico Albano ◽

Riccardo Laudicella ◽

Paola Ferro ◽

Michela Allocca ◽

Elisabetta Abenavoli ◽

...

Keyword(s):

Predictive Value ◽

Fdg Pet ◽

Cell Lymphoma ◽

Multicentric Study ◽

Pet Ct ◽

Mantle Cell ◽

18F Fdg ◽

Sensitivity Specificity ◽

Fdg Pet Ct

Mantle cell lymphoma (MCL) is an aggressive lymphoma subtype with poor prognosis in which 18F-FDG-PET/CT role in treatment response evaluation and prediction of outcome is still unclear. The aim of this multicentric study was to investigate the role of 18F-FDG-PET/CT in staging MCL and the prognostic role of Deauville criteria (DC) in terms of progression-free survival (PFS) and overall survival (OS). We retrospectively enrolled 229 patients who underwent baseline and end-of-treatment (eot) 18F-FDG-PET/CT after first-line therapy. EotPET/CT scans were visually interpreted according to DC. The sensitivity, specificity, positive predictive value, negative predictive value and accuracy of PET/CT for evaluation of bone marrow (BM) were 27%, 100%, 100%, 48% and 57%, respectively. The sensitivity, specificity, positive predictive value, negative predictive value and accuracy of PET/CT for evaluation of the gastrointestinal (GI) tract were 60%, 99%, 93%, 90% and 91%, respectively. At a median follow-up of 40 months, relapse occurred in 104 cases and death in 49. EotPET/CT results using DC significantly correlated with PFS, not with OS. Instead, considering OS, only MIPI score was significantly correlated. In conclusion, we demonstrated that MCL is an FDG-avid lymphoma and 18F-FDG-PET/CT is a useful tool for staging purpose, showing good specificity for BM and GI evaluation, but suboptimal sensitivity. EotPET/CT result was the only independent significant prognostic factor that correlated with PFS.

Download Full-text