scholarly journals Health Care Monitoring and Treatment for Coronary Artery Diseases: Challenges and Issues

Sensors ◽  
2020 ◽  
Vol 20 (15) ◽  
pp. 4303
Author(s):  
Mokhalad Alghrairi ◽  
Nasri Sulaiman ◽  
Saad Mutashar
Keyword(s):  
Coronary Artery ◽  
Blood Clotting ◽  
Coronary Artery Diseases ◽  
Monitoring Technology ◽  
Stent Restenosis ◽  
Increased Risk ◽  
Cause Of Deaths ◽  
One Year ◽  
Health Care Monitoring ◽  
In Stent Restenosis

In-stent restenosis concerning the coronary artery refers to the blood clotting-caused re-narrowing of the blocked section of the artery, which is opened using a stent. The failure rate for stents is in the range of 10% to 15%, where they do not remain open, thereby leading to about 40% of the patients with stent implantations requiring repeat procedure within one year, despite increased risk factors and the administration of expensive medicines. Hence, today stent restenosis is a significant cause of deaths globally. Monitoring and treatment matter a lot when it comes to early diagnosis and treatment. A review of the present stent monitoring technology as well as the practical treatment for addressing stent restenosis was conducted. The problems and challenges associated with current stent monitoring technology were illustrated, along with its typical applications. Brief suggestions were given and the progress of stent implants was discussed. It was revealed that prime requisites are needed to achieve good quality implanted stent devices in terms of their size, reliability, etc. This review would positively prompt researchers to augment their efforts towards the expansion of healthcare systems. Lastly, the challenges and concerns associated with nurturing a healthcare system were deliberated with meaningful evaluations.

scholarly journals Drug-Coated Balloon and In-Stent Restenosis: A Clinical Strategy to Manage Coronary Artery Diseases

2021 ◽  
Author(s):  
Prima Hapsari Wulandari
Keyword(s):  
Coronary Artery ◽  
Management Strategies ◽  
Coronary Intervention ◽  
Myocardial Infarctions ◽  
Coronary Artery Diseases ◽  
Stent Restenosis ◽  
Effective Interventions ◽  
Drug Coated Balloon ◽  
In Stent Restenosis ◽  
Clinical Strategy

Cardiovascular events are the most common cause of morbidity and mortality worldwide. Coronary artery diseases, including myocardial infarctions, are prevalent among all populations. There are multiple management strategies for coronary artery diseases, but stent implantation is among the most effective interventions. Nevertheless, some patients develop restenosis of the intervened vessel, and the number constitutes about 10%-20% of all patients. In-stent restenosis leads to adverse effects that might end in sudden cardiac death. Restenosis forges a clinical challenge for practicing physicians. A drug-coated balloon has propitious potential and is showing results comparable to stents implantation to overcome in-stent restenosis. This review aims to evaluate the effectiveness and advancement of drug-coated balloons in treating in-stent restenosis as a coronary intervention, along with its benefits and drawbacks.

Molecular Evaluation of MicroRNA-146 Gene Variability (rs2910164 C> G) and its Association with Increased Susceptibility to Coronary Artery Disease

MicroRNA ◽  
2020 ◽  
Vol 09 ◽  
Author(s):  
Rashid Mir ◽  
Imadeldin Elfaki ◽  
Chandan k Jha ◽  
Jamsheed Javid ◽  
Suriya Rehman ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Genetic Factors ◽  
Mirna Gene ◽  
Amplification Refractory Mutation System ◽  
Coronary Artery Diseases ◽  
Increased Risk ◽  
Inheritance Model ◽  
Artery Disease ◽  
Increased Susceptibility

Aim: Apart from the modifiable risk factors, genetic factors are believed to also influence the outcome of the coronary artery diseases (CAD). Under the genetic factors, miRNA polymorphisms, namely Hsa-miR-146a-5p (rs2910164) have become an important tool to study the mechanism that underlies the pathogenesis of this disease. Therefore, we investigated the association of miR-146a gene variations with susceptibility of coronary artery diseases. Methodology: This study was conducted on 100 CAD patients and 117 matched healthy individuals. Genotyping of the Hsa-miR-146a-5p C>G gene variation was performed by using amplification refractory mutation system PCR method (ARMS-PCR). Results: The distribution of Hsa-miR-146a-5p rs2910164 C>G genotypes observed between patients and controls was significantly different (P=0.048). Moreover, the frequency of G allele (fG) was found to be significantly higher among patients than in controls (0.36 vs. 0.25). Our findings showed that the Hsa-miR-146a-5p C>G variant was associated with an increased risk of CAD in codominant inheritance model CC vs. CG genotype (OR = 1.84, 95 % CI, 1.02-3.31; p=0.040) and (OR = 3.18, 95 % CI, 1.02-9.9; p=0.045) for CC vs. GG genotype in dominant inheritance model. Whereas the G allele significantly increased the risk of coronary artery disease (OR =1,81, 95 % CI, 1.18-2.78; p=0.006) compared to C allele. Taken together, these results demonstrated that miR-146a/rs2910164 is associated with susceptibility to coronary artery disease, providing novel insights into the genetic etiology and underlying biology of coronary artery disease. Conclusion: Our findings indicated that Hsa-miR-146a-5p rs2910164 GG genotype and G allele are associated with an increased susceptibility to Coronary Artery Disease. A larger sample size can be the key to progress in establishing the genetic co-relation of miRNA gene polymorphisms and cardiovascular diseases.

Evaluation of Coronary Artery In-stent Restenosis by 64-Section Computed Tomography

2010 ◽  
Vol 25 (1) ◽  
pp. 57-63 ◽  
Author(s):  
Sang-Hoon Chung ◽  
Young Jin Kim ◽  
Jin Hur ◽  
Hye Jeong Lee ◽  
Kyu Ok Choe ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Coronary Artery ◽  
Stent Restenosis ◽  
In Stent Restenosis

scholarly journals Drug-eluting balloon treatment in femoropopliteal in-stent restenosis of different lengths

2020 ◽  
Vol 28 (3) ◽  
pp. 460-466
Author(s):  
Berkan Özpak
Keyword(s):  
Stent Restenosis ◽  
Significant Difference ◽  
Stent Length ◽  
Drug Eluting ◽  
Group 3 ◽  
Group 2 ◽  
Drug Eluting Balloon ◽  
One Year ◽  
In Stent Restenosis ◽  
Group 1

Background: In this study, we present one-year results of drug-eluting balloon treatment of femoropopliteal in-stent restenosis. Methods: A total of 62 patients (48 males, 14 females; mean age 64.2±9.1 years; range, 54 to 81 years) who underwent drug-eluting balloon stenting for femoropopliteal in-stent restenosis between August 2013 and October 2017 were included in the study. The patients were classified into three groups based on the narrowing length of stenosis in the stents. Group/Class 1 (n=17): narrowing <1/2 of the stent length; Group/Class 2 (n=22): narrowing >1/2 of the stent length, not totally occluded; and Group/Class 3 (n=23): totally occluded. In-stent restenosis was treated with drug-eluting balloon treatment. Results: There was a significant difference among all classes in terms of in-stent restenosis. The length of stenosis was a predictor for in-stent restenosis. The mean stent length was 107.7±24.6 mm in Group 1, 164.6±17.9 mm in Group 2, and 180±19.3 mm in Group 3. For non-occluded in-stent restenosis, restenosis rate at one year after balloon angioplasty was 47.1% in Group 1, 86.4% in Group 2, and 95.7% in Group 3. Femoropopliteal bypass was performed in five patients in whom treatment failed. None of the patients required amputation. Conclusion: The length of in-stent restenosis in the femoropopliteal arterial stents is an important predictor for recurrent stenosis, when re-flow is achieved with drug-eluting balloons.

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