scholarly journals Human Papillomavirus-Related Multiphenotypic Sinonasal Carcinoma—An Even Broader Tumor Entity?

Viruses ◽  
2021 ◽  
Vol 13 (9) ◽  
pp. 1861
Author(s):  
Mark Zupancic ◽  
Anders Näsman
Keyword(s):  
Systematic Review ◽  
Human Papillomavirus ◽  
Tumor Subtype ◽  
Tumor Characterization ◽  
Sinonasal Carcinoma ◽  
Tumor Entity ◽  
Favorable Clinical Outcome ◽  
Multiphenotypic Sinonasal Carcinoma ◽  
Definition Of

Human papillomavirus (HPV)-related multiphenotypic sinonasal carcinoma (HMSC) is a recently defined tumor subtype with apparent favorable clinical outcome despite aggressive histomorphology. However, in recent years, additional numbers of cases, with more variable features and at locations outside the sinonasal region, have complicated the definition of HMSC. Here, we have performed a systematic review of all cases described so far in order to accumulate more knowledge. We identified 127 articles published between 2013 and 2021, of which 21 presented unique cases. In total, 79 unique patient cases were identified and their clinical and micromorphological nature are herein summarized. In our opinion, better clinical follow-up data and a more detailed tumor characterization are preferably needed before HMSC can finally be justified as its own tumor entity.

Human papillomavirus-related multiphenotypic sinonasal carcinoma

2021 ◽  
Author(s):  
Yohei Morishita ◽  
Shingo Sakashita ◽  
Toshifumi Tomioka ◽  
Wataru Okano ◽  
Takeshi Shinozaki ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
Sinonasal Carcinoma ◽  
Multiphenotypic Sinonasal Carcinoma

Identification of 11 Different HPV Subtypes in Adult Patients With Recurrent Respiratory Papillomatosis

2020 ◽  
Vol 163 (4) ◽  
pp. 785-790
Author(s):  
Rebecca C. Hoesli ◽  
Melissa L. Wingo ◽  
Brent E. Richardson ◽  
Robert W. Bastian
Keyword(s):  
Human Papillomavirus ◽  
Patient Outcomes ◽  
Clinical Course ◽  
Adult Population ◽  
Tertiary Care ◽  
Recurrent Respiratory Papillomatosis ◽  
Definition Of ◽  
Large Adult

Objective To define the human papillomavirus (HPV) subtypes seen in a large adult population with traditionally defined recurrent respiratory papillomatosis. Study Design Retrospective review. Setting Tertiary care laryngology practice. Subjects and Methods All patients had a firm diagnosis of recurrent respiratory papillomatosis defined by (1) visually obvious papillomas, (2) recurrence requiring multiple surgeries, and (3) pathology diagnosis of “papilloma.” Each patient had also undergone HPV subtyping. Age, sex, presence of malignancy, and HPV subtypes were tabulated and correlated with long-term patient outcomes. Results A total of 184 patients were identified who fulfilled the above criteria. In total, 87.0% (160) had a low risk subtype; 9.2% had an alternative subtype. These consisted of subtypes 16, 18, 31, 44, 45, 55, and 70. Four patients (2.2%) had combinations of subtypes, with 1 patient with HPV 11 and 16, 1 patient with HPV 11 and 76, 1 patient with 11 and 84, and 1 patient with 18 and 45. Finally, 3.8% of patients were HPV negative, despite fulfilling all 3 criteria listed above. Conclusion In the patient population above, almost 10% of patients had an HPV subtype other than 6 and 11. This suggests that traditionally defined recurrent respiratory papillomatosis (RRP) can be caused by HPV subtypes other than 6 and/or 11. In addition, the clinical course of persons with this definition of RRP appears to vary by subtype, and this information may offer the ability to nuance follow-up instructions, reducing in particular the burden placed upon patients who have RRP caused by subtypes 6 and 11.

scholarly journals Human papillomavirus-related multiphenotypic sinonasal carcinoma: a clinico-pathological dilemma case report

2021 ◽  
Vol 39 ◽  
Author(s):  
Nouha Ben Abdeljelil ◽  
Samiha Mabrouk ◽  
Souheil Khalfaoui ◽  
Mahdi Farjaoui ◽  
Ahlem Bellalah ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
Case Report ◽  
Sinonasal Carcinoma ◽  
Multiphenotypic Sinonasal Carcinoma

HPV-Related Multiphenotypic Sinonasal Carcinoma: A Unique Case

2019 ◽  
Vol 27 (8) ◽  
pp. 888-892 ◽  
Author(s):  
Daniel Ching ◽  
Shadi Pirasteh ◽  
Chanh Ly
Keyword(s):  
Salivary Gland ◽  
Human Papillomavirus ◽  
High Grade ◽  
Salivary Gland Carcinoma ◽  
Unique Case ◽  
Sinonasal Carcinoma ◽  
Adenoid Cystic ◽  
Gland Carcinoma ◽  
Multiphenotypic Sinonasal Carcinoma ◽  
High Risk Hpv

Human papillomavirus (HPV)-related multiphenotypic sinonasal carcinoma (HMSC), originally known as HPV-related carcinoma with adenoid cystic carcinoma-like features, is a recently described neoplasm that presents only in the sinonasal tract, displays features of both a surface-derived carcinoma and a salivary gland carcinoma, and is associated with high-risk HPV, specifically HPV type 33. Majority of the cases display high-grade histologic features, but HMSC paradoxically behaves in a relatively indolent fashion. Distinguishing HMSC from other histologic mimickers is essential as the management and prognosis are significantly different. In this article, we present a unique case of HMSC and review the literature.

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