Mechanical vibration and shock. Cold provocation tests for the assessment of peripheral vascular function

This study sought to examine whether cardiovascular performance during exercise, assessed using the vascular-ventricular coupling index (VVC), was affected by exaggerated blood pressure (EBP) responses in endurance-trained athletes. Subjects were middle-aged endurance-trained men and women. Blood pressure measurements and left ventricular echocardiography were performed in a semiupright position at rest and during steady-state cycling at workloads that elicited 100–110 beats/min ( stage 1) and 130–140 beats/min ( stage 2). These data were used to calculate effective arterial elastance index ( EaI), left ventricular end-systolic elastance index ( ELVI), and their ratio (VVC). Additional measurements of left ventricular volumes and function (i.e., stroke volume, cardiac output, and longitudinal strain) and indirect assessments of peripheral vascular function (i.e., total arterial compliance and peripheral vascular resistance) were examined. Fourteen subjects with EBP (EBP+, 50% men) and 14 sex-matched subjects without EBP (EBP−) participated, with results presented as EBP+ versus EBP−. EaI and ELVI increased from rest to exercise while VVC decreased, but only ELVI was different between groups at stage 1 [7.6 (1.8) vs. 6.4 (1.0) mmHg·ml−1·m−2, P = 0.045] and stage 2 [10.3 (1.6) vs. 8.0 (1.7) mmHg·ml−1·m−2, P < 0.001]. Additional comparisons revealed no group difference in the contribution of the Frank-Starling mechanism or left ventricular and peripheral vascular function during exercise. The cardiovascular adjustment to exercise in athletes with EBP is achieved through a matched increase in both EaI and ELVI, and the absence of between-group differences in left ventricular or peripheral vascular function suggests that other factors may contribute to the EBP response. NEW & NOTEWORTHY Cardiovascular performance during submaximal exercise, assessed using vascular-ventricular coupling, is unaffected by exaggerated blood pressure (EBP) responses in endurance-trained athletes. The underlying mechanisms of EBP in athletes remain unknown as changes in left ventricular and peripheral vascular function during exercise were similar in athletes with and without EBP.

Tu-W21:6 Physical exercise capacity is associated with coronary and peripheral vascular function in healthy young adults

Atherosclerosis Supplements ◽

10.1016/s1567-5688(06)80639-2 ◽

2006 ◽

Vol 7 (3) ◽

pp. 163-164

Author(s):

U. Hägg ◽

B. Wandt ◽

G. Bergström ◽

R. Volkmann ◽

L.-M. Gan

Keyword(s):

Young Adults ◽

Physical Exercise ◽

Exercise Capacity ◽

Vascular Function ◽

Peripheral Vascular

ASSESSMENT OF PERIPHERAL VASCULAR FUNCTION WITH PHOTOPLETHYSMOGRAPHIC PULSE AMPLITUDE: A POPULATION STUDY

Journal of Hypertension ◽

10.1097/00004872-201106001-00527 ◽

2011 ◽

Vol 29 ◽

pp. e197

Author(s):

T. Kuznetsova ◽

G. Szczesny ◽

L. Thijs ◽

D. Jozeau ◽

J. Dhooge ◽

...

Keyword(s):

Population Study ◽

Vascular Function ◽

Pulse Amplitude ◽

Peripheral Vascular

CORP: Ultrasound assessment of vascular function with the passive leg movement technique

Journal of Applied Physiology ◽

10.1152/japplphysiol.00557.2017 ◽

2017 ◽

Vol 123 (6) ◽

pp. 1708-1720 ◽

Cited By ~ 22

Author(s):

Jayson R. Gifford ◽

Russell S. Richardson

Keyword(s):

Vascular Function ◽

Cardiovascular Health ◽

Vascular System ◽

The Elderly ◽

Passive Movement ◽

Flow Mediated Dilation ◽

Peripheral Vascular ◽

Ultrasound Assessment ◽

Leg Movement ◽

Hyperemic Response

As dysfunction of the vascular system is an early, modifiable step in the progression of many cardiovascular diseases, there is demand for methods to monitor the health of the vascular system noninvasively in clinical and research settings. Validated by very good agreement with more technical assessments of vascular function, like intra-arterial drug infusions and flow-mediated dilation, the passive leg movement (PLM) technique has emerged as a powerful, yet relatively simple, test of peripheral vascular function. In the PLM technique, the change in leg blood flow elicited by the passive movement of the leg through a 90° range of motion is quantified with Doppler ultrasound. This relatively easy-to-learn test has proven to be ≤80% dependent on nitric oxide bioavailability and is especially adept at determining peripheral vascular function across the spectrum of cardiovascular health. Indeed, multiple reports have documented that individuals with decreased cardiovascular health such as the elderly and those with heart failure tend to exhibit a substantially blunted PLM-induced hyperemic response (~50 and ~85% reduction, respectively) compared with populations with good cardiovascular health such as young individuals. As specific guidelines have not yet been put forth, the purpose of this Cores of Reproducibility in Physiology (CORP) article is to provide a comprehensive reference for the assessment and interpretation of vascular function with PLM with the aim to increase reproducibility and consistency among studies and facilitate the use of PLM as a research tool with clinical relevance.

Effects of Continuous-Flow Left Ventricular Assist Device Therapy on Peripheral Vascular Function

ASAIO Journal ◽

10.1097/mat.0000000000001447 ◽

2021 ◽

Vol Publish Ahead of Print ◽

Author(s):

Ersin Kaya ◽

Umut Kocabas ◽

Evrim Simsek ◽

Sanem Nalbantgil ◽

Umit Kahraman ◽

...

Keyword(s):

Left Ventricular Assist Device ◽

Ventricular Assist Device ◽

Vascular Function ◽

Continuous Flow ◽

Left Ventricular ◽

Peripheral Vascular ◽

Device Therapy ◽

Assist Device ◽

Ventricular Assist ◽

Left Ventricular Assist