Faculty Opinions recommendation of Conditional ablation of beta1 integrin in skin. Severe defects in epidermal proliferation, basement membrane formation, and hair follicle invagination.

2001 ◽  
Author(s):  
Joshua R Sanes
Keyword(s):  
Basement Membrane ◽  
Hair Follicle ◽  
Membrane Formation ◽  
Epidermal Proliferation ◽  
Beta1 Integrin

scholarly journals Biosynthesis of sulphated macromolecules by rabbit lens epithelium. II. Relationship to basement membrane formation.

1984 ◽  
Vol 99 (3) ◽  
pp. 861-869 ◽  
Author(s):  
J G Heathcote ◽  
R R Bruns ◽  
R W Orkin
Keyword(s):  
Basement Membrane ◽  
Type I Collagen ◽  
Heparan Sulphate ◽  
Significant Proportion ◽  
Type I ◽  
Heparan Sulphate Proteoglycan ◽  
Membrane Formation ◽  
Sulphate Proteoglycan ◽  
Type Iv ◽  
Rabbit Lens

Rabbit lens epithelial cells display a similar "cobblestone" morphology and produce the same complement of sulphated macromolecules (also see Heathcote, J.G., and R.W. Orkin, 1984, J. Cell Biol., 99:852-860) whether grown on plastic or glass, dried films of gelatin or type IV collagen with laminin, or on gels of type I collagen. There was no evidence of basement membrane formation by these cells when they were grown on plastic, glass, or dried films. In contrast, cultures that had been grown on gels deposited a discrete basement membrane that followed the contours of the basal surfaces of the cells and in addition, they secreted amorphous basement membrane-like material that diffused into the interstices of the gel and associated with the collagen fibrils of the gel. A significant proportion (approximately 70%) of the heparan sulphate proteoglycan fraction that was secreted into the culture medium (fraction MI) when the cells were grown on plastic became associated with the cell-gel layer in the gel cultures. Further, when basement membrane was isolated by detergent extraction, greater than 90% of the 35S-labeled material present was in this heparan sulphate proteoglycan.

Nidogen-1 or -2 Promote Basement Membrane Formation in Skin -Type 3D-Cocultures

2004 ◽  
Vol 2004 (Fall) ◽  
Author(s):  
Eva C. Woenne ◽  
Cathrine Schmidt ◽  
Nick Mirancea ◽  
Roswitha Nischt ◽  
Neil Smyth ◽  
...  
Keyword(s):  
Basement Membrane ◽  
Skin Type ◽  
Membrane Formation ◽  
Nidogen 1

scholarly journals Laminin α5 Is Required for Lobar Septation and Visceral Pleural Basement Membrane Formation in the Developing Mouse Lung

2002 ◽  
Vol 246 (2) ◽  
pp. 231-244 ◽  
Author(s):  
Nguyet M. Nguyen ◽  
Jeffrey H. Miner ◽  
Richard A. Pierce ◽  
Robert M. Senior
Keyword(s):  
Basement Membrane ◽  
Mouse Lung ◽  
Membrane Formation
Sign in / Sign up

Export Citation Format

Share Document