Abstract::
In the previous years of research, the use of animal model becomes very common for the screening of novel
drugs. Animal model represents the complex problems of humans into simplest forms which can be extended further to include
the experimental procedure. The most successful models in neuroscience, rats and mice, undoubtedly considered as
one of the best models to understand the psychology of mammalian brain and its associated functions involved in various
behavioral repertoire. Moreover, recently researchers in behavioral neuroscience are focusing more on the use of aquatic animals
especially fish as model species due to their simplicity, and cost effectiveness. Zebrafish (Danio rerio) is a tropical
fish from minnow family a genetic structure surprisingly 84 % similar to humans. It is gaining popularity as a model to
study the mechanism in behavioral neuropharmacology. Moreover, Zebrafish is having numerous advantages over other rodent
models like ease in maintenance due to their small size; breeding power is more, transparency of embryos, overall reduced
cost of experimentation and many more. Nowadays, it is considered as an ideal model to study the neurobehavioral
aspects with relevance to humans. It is also used in varieties of scientific studies like genetics, neuroscience, pharmacology,
and toxicology. In this manuscript, we have described the feasibility and importance of Zebrafish as a model for the screening
of novel drugs for different neurological disorders.
