Faculty Opinions recommendation of A common variant associated with prostate cancer in European and African populations.

Background and Objective. A T-to-C polymorphism that creates a recognition site for the MspA1 restriction enzyme in the 5’ promoter region of CYP17 has been implicated as a risk factor for prostate cancer. To date, many studies have evaluated associations between the CYP17 MspA1 polymorphism and prostate cancer risk; however, the results were controversial. Therefore, the aim of this study was to perform a meta-analysis to investigate the association between the CYP17 MspA1 polymorphism and the risk of prostate cancer. Material and Methods. By searching the Pubmed, Web of Science, ScienceDirect, EBSCO databases, 36 studies including 14 494 cases and 15 971 controls were collected. Odds ratios (ORs) with their 95% confidence intervals (CIs) were used to assess the strength of the association. Results. The overall results showed no significant association between the CYP17 MspA1 polymorphism and the risk of prostate cancer (OR, 1.07; 95% CI, 0.92–1.25 for A2/A2 vs. A1/A1; OR, 1.02; 95% CI, 0.92–1.12 for A1/A2 vs. A1/A1; OR, 1.07; 95% CI, 0.94–1.22 for A2/A2 vs. A1/A2+A1/A1; OR, 1.03; 95% CI, 0.93–1.14 for A1/A2+A2/A2 vs. A1/A1). In the stratified analysis according to ethnicity, no significant associations were observed in Asian, European, and African populations in all genetic models. In the stratified analysis by the source of controls and inpatients were found to have an increased risk of prostate cancer in all genetic models. Conclusions. The meta-analysis suggests that the CYP17 MspA1 polymorphism is unlikely to increase the risk of prostate cancer in a wide population.

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The rs743572 common variant in the promoter of CYP17A1 is not associated with prostate cancer risk or circulating hormonal levels

BJU International ◽

10.1111/j.1464-410x.2007.07272.x ◽

2007 ◽

Vol 0 (0) ◽

pp. 071106220754002-??? ◽

Cited By ~ 1

Author(s):

Gianluca Severi ◽

Vanessa M. Hayes ◽

Andrea A. Tesoriero ◽

Melissa C. Southey ◽

Hoa N. Hoang ◽

...

Keyword(s):

Prostate Cancer ◽

Cancer Risk ◽

Prostate Cancer Risk ◽

Common Variant ◽

Hormonal Levels

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Fine mapping and functional analysis of a common variant in MSMB on chromosome 10q11.2 associated with prostate cancer susceptibility

Proceedings of the National Academy of Sciences ◽

10.1073/pnas.0902104106 ◽

2009 ◽

Vol 106 (19) ◽

pp. 7933-7938 ◽

Cited By ~ 73

Author(s):

H. Lou ◽

M. Yeager ◽

H. Li ◽

J. G. Bosquet ◽

R. B. Hayes ◽

...

Keyword(s):

Prostate Cancer ◽

Functional Analysis ◽

Fine Mapping ◽

Cancer Susceptibility ◽

Common Variant ◽

Prostate Cancer Susceptibility

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A custom genotyping array reveals population-level heterogeneity for the genetic risks of prostate cancer and other cancers in Africa

10.1101/702910 ◽

2019 ◽

Author(s):

Maxine Harlemon ◽

Olabode Ajayi ◽

Paidamoyo Kachambwa ◽

Michelle S. Kim ◽

Corinne N. Simonti ◽

...

Keyword(s):

Prostate Cancer ◽

Association Studies ◽

Genomic Medicine ◽

Sub Saharan Africa ◽

Risk Scores ◽

Genome Wide Association Studies ◽

Genotyping Array ◽

Common Genetic Variants ◽

African Populations ◽

Disease Associations

AbstractAlthough prostate cancer is the leading cause of cancer mortality for African men, the vast majority of known disease associations have been detected in European study cohorts. Furthermore, most genome-wide association studies have used genotyping arrays that are hindered by SNP ascertainment bias. To overcome these disparities in genomic medicine, the Men of African Descent and Carcinoma of the Prostate (MADCaP) Network has developed a genotyping array that is optimized for African populations. The MADCaP Array contains more than 1.5 million markers and an imputation backbone that successfully tags over 94% of common genetic variants in African populations. This array also has a high density of markers in genomic regions associated with cancer susceptibility, including 8q24. We assessed the effectiveness of the MADCaP Array by genotyping 399 prostate cancer cases and 403 controls from seven urban study sites in sub-Saharan Africa. We find that samples from Ghana and Nigeria cluster together, while samples from Senegal and South Africa yield distinct ancestry clusters. Using the MADCaP array, we identified cancer-associated loci that have large allele frequency differences across African populations. Polygenic risk scores were also generated for each genome in the MADCaP pilot dataset, and we found that predicted risks of CaP are lower in Senegal and higher in Nigeria.SignificanceWe have developed an Africa-specific genotyping array which enables investigators to identify novel disease associations and to fine-map genetic loci that are associated with prostate and other cancers.

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Genetic diversity of CYP3A4 and CYP3A5 polymorphisms in North African populations from Morocco and Tunisia

The International Journal of Biological Markers ◽

10.5301/jbm.5000118 ◽

2015 ◽

Vol 30 (1) ◽

pp. 148-151 ◽

Cited By ~ 2

Author(s):

Apolonia Novillo ◽

Alicia Romero-Lorca ◽

María Gaibar ◽

Raoudha Bahri ◽

Nourdin Harich ◽

...

Keyword(s):

Prostate Cancer ◽

Prostate Cancer Risk ◽

Tunisian Population ◽

North African ◽

High Frequencies ◽

Haplotype Variation ◽

Increased Risk ◽

Cytochrome P450 Genes ◽

African Populations ◽

Form Part

The genes CYP3A4 and CYP3A5 form part of a cluster of cytochrome P450 genes involved in drug metabolism reactions. The allelic variants of these genes CYP3A4*1B, CYP3A4*3, CYP3A4*17 and CYP3A5*3 have been linked both to the reduced catalytic activity of cytochromes and to prostate cancer risk in whites, though scarce data exist for North African populations. The main objective of this study was to describe CYP3A4*3, CYP3A4*17, CYP3A4*1B and CYP3A5*3 allele frequencies and haplotype variation in Moroccan Berbers and the general Tunisian population. The data obtained for the Tunisian participants were consistent with the European allele frequency ranges described, while Moroccan Berbers showed high frequencies of CYP3A4*17 (1.8%), CYP3A4*3 (8.5%) and the CYP3A4*1B/CYP3A5*3 haplotype (18.4%). This haplotype, linked to an increased risk of prostate cancer, was detected at a much higher frequency compared with the present Tunisian population (8.4%) or with reported frequencies for populations such as whites (0.6%) or African Americans (5.3%).

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