Faculty Opinions recommendation of Characterization and evidence of mobilization of the LEE pathogenicity island of rabbit-specific strains of enteropathogenic Escherichia coli.

2002 ◽  
Author(s):  
Gadi Frankel
Keyword(s):  
Escherichia Coli ◽  
Pathogenicity Island ◽  
Enteropathogenic Escherichia Coli

scholarly journals Co-ordination of pathogenicity island expression by the BipA GTPase in enteropathogenic Escherichia coli (EPEC)

2003 ◽  
Vol 48 (2) ◽  
pp. 507-521 ◽  
Author(s):  
Andrew J. Grant ◽  
Michele Farris ◽  
Peter Alefounder ◽  
Peter H. Williams ◽  
Martin J. Woodward ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Pathogenicity Island ◽  
Enteropathogenic Escherichia Coli

Distribution of espI among clinical enterohaemorrhagic and enteropathogenic Escherichia coli isolates

2004 ◽  
Vol 53 (11) ◽  
pp. 1145-1149 ◽  
Author(s):  
Rosanna Mundy ◽  
Claire Jenkins ◽  
Jun Yu ◽  
Henry Smith ◽  
Gad Frankel
Keyword(s):  
Escherichia Coli ◽  
Type Iii Secretion ◽  
Severe Disease ◽  
Pathogenicity Island ◽  
Effector Proteins ◽  
Effector Protein ◽  
Enteropathogenic Escherichia Coli ◽  
Type Iii Effector ◽  
Type Iii

Enterohaemorrhagic (EHEC) and enteropathogenic (EPEC) Escherichia coli are important diarrhoeagenic pathogens; infection is dependent on translocation of a number of type III effector proteins. Until recently all the known effectors were encoded on the LEE pathogenicity island, which also encodes the adhesin intimin and the type III secretion apparatus. Recently, a novel non-LEE effector protein, EspI/NleA, which is required for full virulence in vivo and is encoded on a prophage, was identified. The aim of this study was to determine the distribution of espI among clinical EHEC and EPEC isolates. espI was detected in 86 % and 53 % of LEE+ EHEC and EPEC strains, respectively. Moreover, the espI gene was more commonly found in patients suffering from a more severe disease.

scholarly journals Prevalence and Characteristics of the O122 Pathogenicity Island in Typical and Atypical Enteropathogenic Escherichia coli Strains

2010 ◽  
Vol 48 (4) ◽  
pp. 1452-1455 ◽  
Author(s):  
M. A. M. Vieira ◽  
F. A. Salvador ◽  
R. M. Silva ◽  
K. Irino ◽  
T. M. I. Vaz ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Pathogenicity Island ◽  
Enteropathogenic Escherichia Coli

scholarly journals Pathogenicity Island O-122 in enteropathogenic Escherichia coli strains is associated with diarrhea severity in children from Lima Peru

2016 ◽  
Vol 306 (4) ◽  
pp. 231-236 ◽  
Author(s):  
Erik H. Mercado ◽  
Cristian Piscoche ◽  
Carmen Contreras ◽  
David Durand ◽  
Maribel Riveros ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Pathogenicity Island ◽  
Enteropathogenic Escherichia Coli

scholarly journals espC Pathogenicity Island of Enteropathogenic Escherichia coli Encodes an Enterotoxin

2001 ◽  
Vol 69 (1) ◽  
pp. 315-324 ◽  
Author(s):  
Jay L. Mellies ◽  
Fernando Navarro-Garcia ◽  
Iruka Okeke ◽  
Julie Frederickson ◽  
James P. Nataro ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Developing Countries ◽  
Type Iii Secretion ◽  
Short Circuit ◽  
Short Circuit Current ◽  
Pathogenicity Island ◽  
Enteropathogenic Escherichia Coli ◽  
Ussing Chambers ◽  
E Coli ◽  
Enterocyte Effacement

ABSTRACT At least five proteins are secreted extracellularly by enteropathogenic Escherichia coli (EPEC), a leading cause of infant diarrhea in developing countries. However only one, EspC, is known to be secreted independently of the type III secretion apparatus encoded by genes located within the 35.6-kb locus of enterocyte effacement pathogenicity island. EspC is a member of the autotransporter family of proteins, and the secreted portion of the molecule is 110 kDa. Here we determine that the espC gene is located within a second EPEC pathogenicity island at 60 min on the chromosome of E. coli. We also show that EspC is an enterotoxin, indicated by rises in short-circuit current and potential difference in rat jejunal tissue mounted in Ussing chambers. In addition, preincubation with antiserum against the homologous Pet enterotoxin of enteroaggregative E. coli eliminated EspC enterotoxin activity. Like the EAF plasmid, the espCpathogenicity island was found only in a subset of EPEC, suggesting that EspC may play a role as an accessory virulence factor in some but not all EPEC strains.

Sign in / Sign up

Export Citation Format

Share Document