Faculty Opinions recommendation of Dysregulation of protein kinase a signaling in the aged prefrontal cortex: new strategy for treating age-related cognitive decline.

2003 ◽  
Author(s):  
David P Wolfer
Keyword(s):  
Prefrontal Cortex ◽  
Protein Kinase ◽  
Cognitive Decline ◽  
Protein Kinase A ◽  
Age Related ◽  
New Strategy ◽  
Age Related Cognitive Decline ◽  
Kinase A

[3H]cAMP Binding Sites and Protein Kinase A Activity in the Prefrontal Cortex of Suicide Victims

2002 ◽  
Vol 159 (1) ◽  
pp. 66-73 ◽  
Author(s):  
Yogesh Dwivedi ◽  
Robert R. Conley ◽  
Rosalinda C. Roberts ◽  
Carol A. Tamminga ◽  
Ghanshyam N. Pandey
Keyword(s):  
Prefrontal Cortex ◽  
Protein Kinase ◽  
Protein Kinase A ◽  
Binding Sites ◽  
Kinase A

scholarly journals Protein Kinase A Deregulation in the Medial Prefrontal Cortex Impairs Working Memory in Murine Oligophrenin-1 Deficiency

2017 ◽  
Vol 37 (46) ◽  
pp. 11114-11126 ◽  
Author(s):  
Chun-Lei Zhang ◽  
Mattia Aime ◽  
Emilie Laheranne ◽  
Xander Houbaert ◽  
Hajer El Oussini ◽  
...  
Keyword(s):  
Working Memory ◽  
Prefrontal Cortex ◽  
Protein Kinase ◽  
Protein Kinase A ◽  
Medial Prefrontal Cortex ◽  
Kinase A

scholarly journals Dysregulation of Protein Kinase A Signaling in the Aged Prefrontal Cortex

Neuron ◽  
2003 ◽  
Vol 40 (4) ◽  
pp. 835-845 ◽  
Author(s):  
Brian P. Ramos ◽  
Shari G. Birnbaum ◽  
Isabelle Lindenmayer ◽  
Samuel S. Newton ◽  
Ronald S. Duman ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Protein Kinase ◽  
Protein Kinase A ◽  
Kinase A

scholarly journals NR2A-Containing NMDARs in the Prefrontal Cortex Are Required for Working Memory and Associated with Age-Related Cognitive Decline

2016 ◽  
Vol 36 (50) ◽  
pp. 12537-12548 ◽  
Author(s):  
Joseph A. McQuail ◽  
B. Sofia Beas ◽  
Kyle B. Kelly ◽  
Kailey L. Simpson ◽  
Charles J. Frazier ◽  
...  
Keyword(s):  
Working Memory ◽  
Prefrontal Cortex ◽  
Cognitive Decline ◽  
Age Related ◽  
Age Related Cognitive Decline

scholarly journals Cysteine Sulfoxides Enhance Steroid Hormone Production via Activation of the Protein Kinase A Pathway in Testis-Derived I-10 Tumor Cells

Molecules ◽  
2020 ◽  
Vol 25 (20) ◽  
pp. 4694
Author(s):  
Yuya Nakayama ◽  
Hsin-Jung Ho ◽  
Miki Yamagishi ◽  
Hiroyuki Ikemoto ◽  
Michio Komai ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Protein Kinase A ◽  
Tumor Cells ◽  
Steroid Hormone ◽  
Hormone Production ◽  
Onion Extract ◽  
Testosterone Levels ◽  
Age Related ◽  
Cysteine Sulfoxides ◽  
Kinase A

Testosterone plays an important role in male sexual characteristics and maturation, and decreased testosterone levels increase the risk of several diseases. Recently, onion extract rich in cysteine sulfoxides, which are amino acids unique to onions, has been reported to alleviate age-related symptoms resulting from decreased testosterone levels in males. However, the mechanism underlying the suppression of low testosterone levels by cysteine sulfoxides has not been elucidated. In this study, we found that onion extract containing cysteine sulfoxides enhanced progesterone, a precursor of testosterone, in mouse testis-derived I-10 tumor cells. Furthermore, cysteine sulfoxides activated protein kinase A (PKA) and cyclic adenosine monophosphate response element-binding protein, which are key factors in steroidogenesis. These results suggest that cysteine sulfoxides enhance steroid hormone production via activation of the PKA signaling pathway.

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