Faculty Opinions recommendation of RNAi reveals doublecortin is required for radial migration in rat neocortex.

Author(s):  
Sally Temple
2003 ◽  
Vol 6 (12) ◽  
pp. 1277-1283 ◽  
Author(s):  
Jilin Bai ◽  
Raddy L Ramos ◽  
James B Ackman ◽  
Ankur M Thomas ◽  
Richard V Lee ◽  
...  

10.1038/83967 ◽  
2001 ◽  
Vol 4 (2) ◽  
pp. 143-150 ◽  
Author(s):  
Bagirathy Nadarajah ◽  
Janice E. Brunstrom ◽  
Jaime Grutzendler ◽  
Rachel O. L. Wong ◽  
Alan L. Pearlman

2020 ◽  
Author(s):  
Elisa Penna ◽  
Jon M Mangum ◽  
Hunter Shepherd ◽  
Veronica Martínez-Cerdeño ◽  
Stephen C Noctor

Abstract Microglial cells make extensive contacts with neural precursor cells (NPCs) and affiliate with vasculature in the developing cerebral cortex. But how vasculature contributes to cortical histogenesis is not yet fully understood. To better understand functional roles of developing vasculature in the embryonic rat cerebral cortex, we investigated the temporal and spatial relationships between vessels, microglia, and NPCs in the ventricular zone. Our results show that endothelial cells in developing cortical vessels extend numerous fine processes that directly contact mitotic NPCs and microglia; that these processes protrude from vessel walls and are distinct from tip cell processes; and that microglia, NPCs, and vessels are highly interconnected near the ventricle. These findings demonstrate the complex environment in which NPCs are embedded in cortical proliferative zones and suggest that developing vasculature represents a source of signaling with the potential to broadly influence cortical development. In summary, cortical histogenesis arises from the interplay among NPCs, microglia, and developing vasculature. Thus, factors that impinge on any single component have the potential to change the trajectory of cortical development and increase susceptibility for altered neurodevelopmental outcomes.


Author(s):  
Veronique Cortay ◽  
Delphine Delaunay ◽  
Dorothée Patti ◽  
Elodie Gautier ◽  
Nathalie Doerflinger ◽  
...  

1998 ◽  
Vol 15 (2) ◽  
pp. 97-109 ◽  
Author(s):  
Carme Casanovas-Aguilar ◽  
Concepción Reblet ◽  
Jeús Pérez-Clausell ◽  
José-Luis Bueno-López
Keyword(s):  

2010 ◽  
Vol 6 (S271) ◽  
pp. 119-126 ◽  
Author(s):  
Francoise Combes

AbstractRecent results are reviewed on galaxy dynamics, bar evolution, destruction and re-formation, cold gas accretion, gas radial flows and AGN fueling, minor mergers. Some problems of galaxy evolution are discussed in particular, exchange of angular momentum, radial migration through resonant scattering, and consequences on abundance gradients, the frequency of bulgeless galaxies, and the relative role of secular evolution and hierarchical formation.


2012 ◽  
Vol 10 (H16) ◽  
pp. 372-372
Author(s):  
Rok Roškar

AbstractIn recent years, effects such as the radial migration of stars in disks have been recognized as important drivers of the properties of stellar populations. Radial migration arises due to perturbative effects of disk structures such as bars and spiral arms, and can deposit stars formed in disks to regions far from their birthplaces. Migrant stars can significantly affect the demographics of their new locales, especially in low-density regions such as in the outer disks. However, in the cosmological environment, other effects such as mergers and filamentary gas accretion also influence the disk formation process. Understanding the relative importance of these processes on the detailed evolution of stellar population signatures is crucial for reconstructing the history of the Milky Way and other nearby galaxies. In the Milky Way disk in particular, the formation of the thickened component has recently attracted much attention due to its potential to serve as a diagnostic of the galaxy's early history. Some recent work suggests, however, that the vertical structure of Milky Way stellar populations is consistent with models that build up the thickened component through migration. I discuss these developments in the context of cosmological galaxy formation.


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