scholarly journals Radial Migration Dynamics Is Modulated in a Laminar and Area-Specific Manner During Primate Corticogenesis

2020 ◽  
Vol 8 ◽  
Author(s):  
Veronique Cortay ◽  
Delphine Delaunay ◽  
Dorothée Patti ◽  
Elodie Gautier ◽  
Nathalie Doerflinger ◽  
...  
Keyword(s):  
Radial Migration ◽  
Specific Manner ◽  
Migration Dynamics

Current Strategies in the Management of Spinal Metastatic Disease

Swiss Surgery ◽  
2003 ◽  
Vol 9 (2) ◽  
pp. 55-62 ◽  
Author(s):  
Bartanusz ◽  
Porchet
Keyword(s):  
Spinal Cord ◽  
Surgical Techniques ◽  
Cord Compression ◽  
Treatment Modalities ◽  
Surgical Approaches ◽  
Spinal Stabilization ◽  
Management Algorithm ◽  
Specific Manner ◽  
Extensive Surgery ◽  
Selection Of

The treatment of metastatic spinal cord compression is complex. The three treatment modalities that are currently applied (in a histologically non-specific manner) are surgery, radiotherapy and the administration of steroids. The development of new spinal instrumentations and surgical approaches considerably changed the extent of therapeutic options in this field. These new surgical techniques have made it possible to resect these tumours totally, with subsequent vertebral reconstruction and spinal stabilization. In this respect, it is important to clearly identify those patients who can benefit from such an extensive surgery. We present our management algorithm to help select patients for surgery and at the same time identifying those for whom primary non-surgical therapy would be indicated. The retrospective review of surgically treated patients in our department in the last four years reveals a meagre application of conventional guidelines for the selection of the appropriate operative approach in the surgical management of these patients. The reasons for this discrepancy are discussed.

A Physiologic Regulator of Collagen-Induced Platelet Aggregation: Inhibition by Clq

1981 ◽  
Vol 45 (02) ◽  
pp. 110-115 ◽  
Author(s):  
György Csákó ◽  
Eva A Suba
Keyword(s):  
Platelet Aggregation ◽  
Human Platelet ◽  
Platelet Reactivity ◽  
High Specificity ◽  
Turbidimetric Method ◽  
Specific Manner ◽  
Aggregation Inhibition ◽  
Different Tissues

SummaryPlatelet aggregations were studied by a turbidimetric method in citrated human platelet-rich plasmas (PRP) in vitro. Human Clq inhibited the aggregations caused by collagens derived from different tissues and species. Clq was needed by weight in comparable quantities to collagen for neutralizing the aggregating effect. The dependence of the inhibitory reaction on the preincubation of platelets with Clq and the differences in the occurrence of aggregating substances in supernatants of PRP triggered with collagen in the presence or absence of Clq, confirmed that Clq exerts its effect by preventing fixation of collagen to platelets. In addition, the high specificity of the inhibitory action of Clq for collagen-induced platelet aggregation was demonstrated by results obtained for testing a variety of aggregating agents in combination with Clq and/or collagen.Since normal concentrations of Clq in the blood are in the range of inhibitory doses of Clq for collagen-induced platelet aggregations in vitro and upon activation of complement Clq is known to dissociate from Cl, it is proposed that Clq may participate in a highly specific manner in regulating platelet reactivity to collagen in vivo.

Autómatas Celulares Aplicados al Comportamiento de Células de Cáncer Cervicouterino

2019 ◽  
Vol 6 (1) ◽  
pp. 44-49
Author(s):  
Tania Muñoz Jiménez ◽  
Aurora Torres Soto ◽  
María Dolores Torres Soto
Keyword(s):  
Cellular Automaton ◽  
Medical Model ◽  
Research Process ◽  
Simulation Algorithm ◽  
Stages Of Development ◽  
Literary Research ◽  
Migration Dynamics ◽  
Three Stages ◽  
And Migration ◽  
Best Parameters

En este documento se describe el desarrollo e implementación de un modelo para simular computacionalmente la dinámica del crecimiento y migración del cáncer cervicouterino, considerando sus principales características: proliferación, migración y necrosis, así como sus etapas de desarrollo. El modelo se desarrolló mediante un autómata celular con enfoques paralelo y secuencial. El autómata celular se basó en el modelo de Gompertz para simular las etapas de desarrollo de este cáncer, el cual se dividió en tres etapas cada una con diferentes comportamientos durante la simulación. Se realizó un diseño experimental con parámetros de entrada que se seleccionaron a partir de la investigación literaria y su discusión con médicos expertos. Al final del proceso de investigación, se logró obtener un algoritmo computacional de simulación muy bueno comparado con el modelo médico de Gompertz y se encontraron los mejores parámetros para su ejecución mediante un diseño factorial soportado estadísticamente. This paper describes the development and implementation of a model to computationally simulate the growth and migration dynamics of cervical cancer, considering its main characteristics: proliferation, migration and necrosis, as well as its stages of development. The model was developed by means of a cellular automaton with parallel and sequential approaches. The cellular automaton was based on the model of Gompertz to simulate the stages of development of this cancer, which was divided into three stages, each with different behaviors during the simulation. An experimental design was carried out with input parameters that were selected from literary research and its discussion with expert physicians. At the end of the research process, a very good simulation algorithm was obtained compared to the Gompertz medical model and the best parameters for its execution were found by means of a statistically supported factorial design.

Fluoride modulates formation and function of bone marrow macrophage-derived osteoclasts in a strain-specific manner

2016 ◽  
Author(s):  
Oliveira Flavia Amadeu de ◽  
Pereira Amanda Amaral ◽  
Silva Ventura Talita da ◽  
Buzalaf Marilia Afonso Rabelo ◽  
Oliveira Rodrigo Cardoso de ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Bone Marrow Macrophage ◽  
Specific Manner ◽  
And Function

Paternal Bisphenol A Exposure Alters Offspring Glucose Tolerance in a Time, Dose, and Sex-Specific Manner

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 1363-P
Author(s):  
CETEWAYO S. RASHID ◽  
AMITA BANSAL ◽  
REBECCA A. SIMMONS
Keyword(s):  
Glucose Tolerance ◽  
Bisphenol A ◽  
Specific Manner ◽  
Time Dose

Pescadores migrantes: análisis de su dinámica e integración Social

2019 ◽  
Vol 37 (3) ◽  
pp. 18
Author(s):  
Fernando González Laxe
Keyword(s):  
Renewable Resources ◽  
Sustainable Management ◽  
Social Groups ◽  
Technological Innovations ◽  
Social Competition ◽  
Factors Affecting ◽  
Fish Stocks ◽  
Fishery Resources ◽  
Migration Dynamics ◽  
The Many

The globalization of the economy encourages massive population displacements and inevitably generates a cosmopolitization of societies. This leads to concern, misunderstanding and rejection. The most vulnerable social groups in society can perceive the population as intruders and enemies in social competition. Undoubtedly, the extreme spatial instability of fishery resources is among the many factors affecting migration dynamics. Various reasons for the mobility of fishermen are relevant around this concept. These include aspect related to traditions, to the capitalisation of activity, to technological innovations, and to innovation exchanges concerning the location of fish stocks. This article reflects on spatial increase of fishermen’s. The analyse are part of the paradigm of the sustainable management of common renewable resources, in particular fishery resources. It presents three lines of analysis: the reason for mobility; the choice of destination; and are the integration into host units.

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