Faculty Opinions recommendation of Pair rule gene orthologs in spider segmentation.

2006 ◽  
Author(s):  
Graham Budd
Keyword(s):  
Pair Rule Gene ◽  
Gene Orthologs ◽  
Pair Rule

scholarly journals Shifting roles of Drosophila pair-rule gene orthologs: segmental expression and function in the milkweed bug Oncopeltus fasciatus

Development ◽  
2019 ◽  
Vol 146 (17) ◽  
pp. dev181453 ◽  
Author(s):  
Katie Reding ◽  
Mengyao Chen ◽  
Yong Lu ◽  
Alys M. Cheatle Jarvela ◽  
Leslie Pick
Keyword(s):  
Oncopeltus Fasciatus ◽  
Milkweed Bug ◽  
Pair Rule Gene ◽  
And Function ◽  
Gene Orthologs ◽  
Segmental Expression ◽  
Pair Rule

scholarly journals Expression of pair rule gene orthologs in the blastoderm of a myriapod: evidence for pair rule-like mechanisms?

2012 ◽  
Vol 12 (1) ◽  
pp. 15 ◽  
Author(s):  
Ralf Janssen ◽  
Wim G M Damen ◽  
Graham E Budd
Keyword(s):  
Pair Rule Gene ◽  
Gene Orthologs ◽  
Pair Rule

scholarly journals Expression of myriapod pair rule gene orthologs

EvoDevo ◽  
2011 ◽  
Vol 2 (1) ◽  
pp. 5 ◽  
Author(s):  
Ralf Janssen ◽  
Graham E Budd ◽  
Nikola-Michael Prpic ◽  
Wim GM Damen
Keyword(s):  
Pair Rule Gene ◽  
Gene Orthologs ◽  
Pair Rule

Pair rule gene orthologs in spider segmentation

2005 ◽  
Vol 7 (6) ◽  
pp. 618-628 ◽  
Author(s):  
Wim G. M. Damen ◽  
Ralf Janssen ◽  
Nikola-Michael Prpic
Keyword(s):  
Pair Rule Gene ◽  
Gene Orthologs ◽  
Pair Rule

scholarly journals Shifting roles of Drosophila pair-rule gene orthologs: segmental expression and function in the milkweed bug Oncopeltus fasciatus

2019 ◽  
Author(s):  
Katie Reding ◽  
Mengyao Chen ◽  
Yong Lu ◽  
Alys M. Cheatle Jarvela ◽  
Leslie Pick
Keyword(s):  
Oncopeltus Fasciatus ◽  
Regulatory Pathways ◽  
Milkweed Bug ◽  
Regulatory Circuits ◽  
Hemimetabolous Insect ◽  
Pair Rule Gene ◽  
Summary Statement ◽  
And Function ◽  
Gene Orthologs ◽  
Pair Rule

AbstractThe discovery of pair-rule genes (PRGs) in Drosophila revealed the existence of an underlying two-segment-wide prepattern directing embryogenesis. The milkweed bug Oncopeltus, a hemimetabolous insect, is a more representative arthropod: most of its segments form sequentially after gastrulation. Here we report the expression and function of orthologs of the complete set of nine Drosophila PRGs in Oncopeltus. Seven Of-PRG-orthologs are expressed in stripes in the primordia of every segment, rather than every-other segment, Of-runt is PR-like, and several are also expressed in the segment addition zone. RNAi-mediated knockdown of Of-odd-skipped, paired and sloppy-paired impacted all segments, with no indication of PR-like register. We confirm that Of-E75A is expressed in PR-like stripes, although it is not PR in Drosophila, demonstrating the existence of an underlying PR-like prepattern in Oncopeltus. These findings reveal that a switch occurred in regulatory circuits leading to segment formation: while several holometabolous insects are “Drosophila-like,” utilizing PRG-orthologs for PR-patterning, most Of-PRGs are expressed segmentally in Oncopeltus, a more basally-branching insect. Thus, an evolutionarily stable phenotype – segment formation – is directed by alternate regulatory pathways in diverse species.Summary StatementDespite the broad of conservation of segmentation in insects, the regulatory genes underlying this process in Drosophila have different roles in the hemipteran, Oncopeltus fasciatus.

odd Oz: A novel Drosophila pair rule gene

Cell ◽  
1994 ◽  
Vol 77 (4) ◽  
pp. 587-598 ◽  
Author(s):  
Anna Levine ◽  
Ayelet Bashan-Ahrend ◽  
Ofra Budai-Hadrian ◽  
Devorah Gartenberg ◽  
Sophia Menasherow ◽  
...  
Keyword(s):  
Pair Rule Gene ◽  
Pair Rule

Teneurin-1, a vertebrate homologue of the Drosophila pair-rule gene ten-m, is a neuronal protein with a novel type of heparin-binding domain

1999 ◽  
Vol 112 (12) ◽  
pp. 2019-2032 ◽  
Author(s):  
A.D. Minet ◽  
B.P. Rubin ◽  
R.P. Tucker ◽  
S. Baumgartner ◽  
R. Chiquet-Ehrismann
Keyword(s):  
Sequence Motifs ◽  
Heparin Binding ◽  
Terminal Part ◽  
Phylogenetic Conservation ◽  
Neuronal Protein ◽  
Repeat Proteins ◽  
Heparin Binding Domain ◽  
Pair Rule Gene ◽  
Pair Rule

The Drosophila gene ten-m is the first pair-rule gene not encoding a transcription factor, but an extracellular protein. We have characterized a highly conserved chicken homologue that we call teneurin-1. The C-terminal part harbors 26 repetitive sequence motifs termed YD-repeats. The YD-repeats are most similar to the core of the rhs elements of Escherichia coli. Related repeats in toxin A of Clostridium difficile are known to bind specific carbohydrates. We show that recombinantly expressed proteins containing the YD-repeats of teneurin-1 bind to heparin. Furthermore, heparin lyase treatment of extracts of cells expressing recombinant YD-repeat protein releases this protein from high molecular mass aggregates. In situ hybridization and immunostaining reveals teneurin-1 expression in neurons of the developing visual system of chicken and Drosophila. This phylogenetic conservation of neuronal expression from flies to birds implies fundamental roles for teneurin-1 in neurogenesis. This is supported by the neurite outgrowth occurring on substrates made of recombinant YD-repeat proteins, which can be inhibited by heparin. Database searches resulted in the identification of ESTs encoding at least three further members of the teneurin family of proteins. Furthermore, the human teneurin-1 gene could be identified on chromosome Xq24/25, a region implied in an X-linked mental retardation syndrome.

Sign in / Sign up

Export Citation Format

Share Document