Faculty Opinions recommendation of Cigarette smoke-induced blockade of the mitochondrial respiratory chain switches lung epithelial cell apoptosis into necrosis.

2007 ◽  
Author(s):  
Rubin Tuder
Keyword(s):  
Epithelial Cell ◽  
Cigarette Smoke ◽  
Respiratory Chain ◽  
Cell Apoptosis ◽  
Mitochondrial Respiratory Chain ◽  
Lung Epithelial Cell ◽  
Lung Epithelial ◽  
Epithelial Cell Apoptosis ◽  
Mitochondrial Respiratory

Cigarette smoke-induced blockade of the mitochondrial respiratory chain switches lung epithelial cell apoptosis into necrosis

2007 ◽  
Vol 292 (5) ◽  
pp. L1211-L1218 ◽  
Author(s):  
Marco van der Toorn ◽  
Dirk-Jan Slebos ◽  
Harold G. de Bruin ◽  
Henri G. Leuvenink ◽  
Stephan J. L. Bakker ◽  
...  
Keyword(s):  
Epithelial Cell ◽  
Cigarette Smoke ◽  
Respiratory Chain ◽  
Cell Apoptosis ◽  
Mitochondrial Respiratory Chain ◽  
Cigarette Smoke Extract ◽  
Chronic Obstructive ◽  
Epithelial Cell Apoptosis ◽  
Cellular Necrosis ◽  
Mitochondrial Respiratory

Increased lung cell apoptosis and necrosis occur in patients with chronic obstructive pulmonary disease (COPD). Mitochondria are crucially involved in the regulation of these cell death processes. Cigarette smoke is the main risk factor for development of COPD. We hypothesized that cigarette smoke disturbs mitochondrial function, thereby decreasing the capacity of mitochondria for ATP synthesis, leading to cellular necrosis. This hypothesis was tested in both human bronchial epithelial cells and isolated mitochondria. Cigarette smoke extract exposure resulted in a dose-dependent inhibition of complex I and II activities. This inhibition was accompanied by decreases in mitochondrial membrane potential, mitochondrial oxygen consumption, and production of ATP. Cigarette smoke extract abolished the staurosporin-induced caspase-3 and -7 activities and induced a switch from epithelial cell apoptosis into necrosis. Cigarette smoke induced mitochondrial dysfunction, with compounds of cigarette smoke acting as blocking agents of the mitochondrial respiratory chain; loss of ATP generation leading to cellular necrosis instead of apoptosis is a new pathophysiological concept of COPD development.

Lung epithelial cell apoptosis during acute lung injury in infancy

2007 ◽  
Vol 8 (2) ◽  
pp. 132-137 ◽  
Author(s):  
Reinout A. Bem ◽  
Albert P. Bos ◽  
Gustavo Matute-Bello ◽  
Minke van Tuyl ◽  
Job B. M. van Woensel
Keyword(s):  
Acute Lung Injury ◽  
Epithelial Cell ◽  
Lung Injury ◽  
Cell Apoptosis ◽  
Lung Epithelial Cell ◽  
Lung Epithelial ◽  
Epithelial Cell Apoptosis

Pyrrolidine dithiocarbamate (PDTC)/Cu complex induces lung epithelial cell apoptosis through mitochondria and ER-stress pathways

2010 ◽  
Vol 199 (3) ◽  
pp. 333-340 ◽  
Author(s):  
Ya-Wen Chen ◽  
Kuo-Liang Chen ◽  
Chun-Hung Chen ◽  
Hsi-Chin Wu ◽  
Chin-Chuan Su ◽  
...  
Keyword(s):  
Epithelial Cell ◽  
Er Stress ◽  
Cell Apoptosis ◽  
Lung Epithelial Cell ◽  
Pyrrolidine Dithiocarbamate ◽  
Cu Complex ◽  
Lung Epithelial ◽  
Epithelial Cell Apoptosis

scholarly journals Role of mitochondrial hOGG1 and aconitase in oxidant-induced lung epithelial cell apoptosis

2009 ◽  
Vol 47 (6) ◽  
pp. 750-759 ◽  
Author(s):  
V. Panduri ◽  
G. Liu ◽  
S. Surapureddi ◽  
J. Kondapalli ◽  
S. Soberanes ◽  
...  
Keyword(s):  
Epithelial Cell ◽  
Cell Apoptosis ◽  
Lung Epithelial Cell ◽  
Lung Epithelial ◽  
Epithelial Cell Apoptosis

Molecular mechanisms of asbestos-induced lung epithelial cell apoptosis

2010 ◽  
Vol 188 (2) ◽  
pp. 309-318 ◽  
Author(s):  
Gang Liu ◽  
Rohinee Beri ◽  
Amanda Mueller ◽  
David W. Kamp
Keyword(s):  
Epithelial Cell ◽  
Cell Apoptosis ◽  
Molecular Mechanisms ◽  
Lung Epithelial Cell ◽  
Lung Epithelial ◽  
Epithelial Cell Apoptosis

Attenuation of GSTP1 Decreases Fas SGlutathionylation-Mediated Lung Epithelial Cell Apoptosis and Fibrotic Remodeling

2014 ◽  
Vol 76 ◽  
pp. S164
Author(s):  
David McMillan ◽  
Karolyn Lahue ◽  
James Nolin ◽  
Sidra Hoffman ◽  
Sarah Abdalla ◽  
...  
Keyword(s):  
Epithelial Cell ◽  
Cell Apoptosis ◽  
Lung Epithelial Cell ◽  
Lung Epithelial ◽  
Epithelial Cell Apoptosis
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