Faculty Opinions recommendation of B-cell depletion with rituximab in relapsing-remitting multiple sclerosis.

2015 ◽  
Author(s):  
Joan Goverman
Keyword(s):  
Multiple Sclerosis ◽  
B Cell ◽  
Cell Depletion ◽  
B Cell Depletion ◽  
Relapsing Remitting ◽  
Remitting Multiple Sclerosis ◽  
Relapsing Remitting Multiple Sclerosis

B-Cell Depletion with Rituximab in Relapsing–Remitting Multiple Sclerosis

2008 ◽  
Vol 358 (7) ◽  
pp. 676-688 ◽  
Author(s):  
Stephen L. Hauser ◽  
Emmanuelle Waubant ◽  
Douglas L. Arnold ◽  
Timothy Vollmer ◽  
Jack Antel ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
B Cell ◽  
Cell Depletion ◽  
B Cell Depletion ◽  
Relapsing Remitting ◽  
Remitting Multiple Sclerosis ◽  
Relapsing Remitting Multiple Sclerosis

scholarly journals B cell depletion can be effective in multiple sclerosis but failed in a patient with advanced childhood cerebral X-linked adrenoleukodystrophy

2019 ◽  
Vol 12 ◽  
pp. 175628641986813
Author(s):  
Hendrik Rosewich ◽  
Stefan Nessler ◽  
Wolfgang Brück ◽  
Jutta Gärtner
Keyword(s):  
Multiple Sclerosis ◽  
B Cell ◽  
B Lymphocytes ◽  
Specific Pattern ◽  
B Cell Depletion ◽  
Compassionate Use ◽  
Clinical Imaging ◽  
Relapsing Remitting ◽  
Advanced Stages ◽  
Relapsing Remitting Multiple Sclerosis

Rituximab exerts its clinical efficacy by its specific pattern of depletion of CD20+ B lymphocytes and it has been demonstrated that rituximab is an effective treatment for relapsing remitting multiple sclerosis. X-linked adrenoleukodystrophy (X-ALD), the most common monogenetic neuroinflammatory disorder, shares substantial overlap with multiple sclerosis in the neuropathological changes found in brain tissues in advanced stages of the disease. While there is no effective therapy for these patients, we hypothesized that rituximab might be effective in arresting the neuroinflammatory process. Our detailed clinical, imaging and immunological data revealed that rituximab is not effective in advanced stages of X-ALD and consequently should not be applied for compassionate use in these patients.

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