<p>Parenteral nutrition (PN) is a valuable life saving intervention, which can improve the nutritional status of hospitalized malnourished patients. PN is associated with complications including hyperglycemia. This study was conducted to compare two methods of blood glucose control in traumatic brain injury patients who are on PN.</p>
<p><strong>Materials & Methods:</strong>This study is a randomized , open-label, controlled clinical trial with blinded end assessment. This study was done in the surgical intensive care unit of Beni-Suef University hospital after obtaining approval from the ethical committee of the Institution and obtaining consent from relatives of the patients involved in the study. Seventy critically ill patients were choosen randomly according to the inclusion criteria from cases admitted to Beni-suef university hospital, then divided into two groups randomly:</p>
<p><strong>Group </strong><strong>?</strong><strong> (Intensive insulin therapy):</strong>35 patients received continuous insulin infusion to maintain glucose levels between 4.4mmol/l (80 mg/dl) and 6.6mmol/l (110 mg/dl).</p>
<p><strong>Group </strong><strong>??</strong><strong> (Conventional therapy):</strong>35patients not received insulin unless glucose levels greater than 10 mmol/l (>180 mg/dl).</p>
<p><strong>Results: </strong>In our study, it was shown that mean glucose concentration were significantly lower in IIT group vs conventional group. No hypoglycemic episode occurred in two groups. Triglyceride and C-reactive protein was decreased in the IIT group, significantly. There were also significant differences in the electrolytes, with magnesium and phosphorus being lower in the IIT group.</p>
<p><strong>Conclusion:</strong> In this study, Intensive insulin group improved some of parenteral such as hyperglycemia, hypertriglyceridemia and electrolyte imbalances compared to Conventional insulin group.</p>
Intensive Insulin Therapy Versus Conventional Glucose Control In Traumatic Brain Injury Patients Who Are On Parenteral Nutrition
