Faculty Opinions recommendation of Expression of osteoclast differentiation signals by stromal elements of giant cell tumors.

2009 ◽  
Author(s):  
David Thomas
Keyword(s):  
Giant Cell ◽  
Osteoclast Differentiation ◽  
Giant Cell Tumors

Giant Cell Tumors: Inquiry Into Immunohistochemical Expression of CD117 (c-Kit), Microphthalmia Transcription Factor, Tartrate-Resistant Acid Phosphatase, and HAM-56

2005 ◽  
Vol 129 (3) ◽  
pp. 360-365
Author(s):  
Rolando Y. Ramos ◽  
Helen M. Haupt ◽  
Peter A. Kanetsky ◽  
Rakesh Donthineni-Rao ◽  
Carmen Arenas-Elliott ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Acid Phosphatase ◽  
Giant Cell ◽  
Stromal Cells ◽  
Mononuclear Cells ◽  
Osteoclast Differentiation ◽  
Tartrate Resistant Acid Phosphatase ◽  
Immunohistochemical Expression ◽  
Giant Cell Tumors ◽  
Microphthalmia Transcription Factor

Abstract Context.—Osteoclast-like giant cells (GCs) in giant cell tumors (GCTs) are thought to derive from a monocyte-macrophage lineage. Microphthalmia transcription factor (MITF) is necessary for osteoclast gene expression and tartrate-resistant acid phosphatase (TRAP) activation; c-Kit plays a role in regulation of MITF. Objective.—To gain insight into the differentiation of GCTs of bone (GCTBs) and GCTs tendon sheath (GCTTSs) by investigating immunohistochemical staining for c-Kit, MITF, TRAP, and HAM-56 in the GCs and stroma. Design.—Immunoreactivity for CD117 (c-Kit), MITF, TRAP, and HAM-56 was studied in 35 GCTBs, 15 GCTTSs, and 5 foreign-body GC controls. Results.—Across tumors, MITF and TRAP but not c-Kit were generally expressed in GCs; TRAP was variably expressed in stromal cells. The MITF was expressed more consistently in stromal cells of GCTTSs than GCTBs (P < .001). The GCTBs showed more intense MITF stromal (P < .001) and TRAP GC staining (P = .04) than GCTTSs. HAM-56 staining by stromal cells was associated with MITF stromal staining (r2 = 0.6, P < .001). Conclusions.—Results suggest that MITF and TRAP are expressed during osteoclast differentiation and that a proportion of mononuclear cells in GCTs express the macrophage marker HAM-56. Both GCTBs and GCTTSs show similar patterns of immunohistochemical expression.

scholarly journals Expression of Osteoclast Differentiation Signals by Stromal Elements of Giant Cell Tumors

2010 ◽  
Vol 15 (4) ◽  
pp. 640-649 ◽  
Author(s):  
Gerald J. Atkins ◽  
David R. Haynes ◽  
Stephen E. Graves ◽  
Andreas Evdokiou ◽  
Shelley Hay ◽  
...  
Keyword(s):  
Giant Cell ◽  
Osteoclast Differentiation ◽  
Giant Cell Tumors

Imaging and Clinical Findings of Temporal Bone Giant Cell Tumors

Skull Base ◽  
2008 ◽  
Vol 18 (S 01) ◽  
Author(s):  
Masoud Zarandy ◽  
Mohammad Ashtiani ◽  
Nasrin Yazdani
Keyword(s):  
Giant Cell ◽  
Temporal Bone ◽  
Clinical Findings ◽  
Giant Cell Tumors

scholarly journals Imaging Features of Aggressive Giant Cell Tumors of the Mobile Spine: Retrospective Analysis of 101 Patients From Single Center

2021 ◽  
pp. 219256822098228
Author(s):  
Bei Yuan ◽  
Lihua Zhang ◽  
Shaomin Yang ◽  
Hanqiang Ouyang ◽  
Songbo Han ◽  
...  
Keyword(s):  
Giant Cell ◽  
Vertebral Body ◽  
Signal Intensity ◽  
Imaging Features ◽  
Single Center ◽  
Giant Cell Tumors ◽  
Ct Guided ◽  
Cortical Destruction ◽  
Mobile Spine ◽  
T2 Weighted Images

Study Design: Retrospective study. Objectives: Giant cell tumors (GCTs) of the mobile spine can be locally aggressive. This study described and classified the typical and atypical appearance of aggressive spinal GCTs according to imaging findings to help the imaging diagnosis, especially for patients with rapid neurological deficit that may require emergent surgery without biopsy. Methods: Computed tomography (CT) and magnetic resonance imaging (MRI) scans of patients diagnosed with aggressive spinal GCTs at single center were reviewed. Results: Overall, 101 patients with 100 CT images and 94 MR images were examined. All lesions were osteolytic with cortical destruction; 95 lesions showed epidural extension; 90 were centered in the vertebral body; 82 showed pathological fracture and/or collapse of the vertebral body; 78 had pseudotrabeculation on CT; 80 showed low-to-iso signal intensity or heterogeneous high-signal intensity with cystic areas on the T2-weighted images; 9 showed fluid–fluid level on T2-weighted images; and 61 patients showed marked enhancement on contrast-enhanced CT and/or MRI. Forty-one lesions (40.6%) had at least 1 atypical radiographic feature: 19 involved ≥2 segments; 11 were centered in the posterior neural arch; 10 had a paravertebral mass over 2 segments; 16 showed partial margin sclerosis with partial cortical destruction on CT scans; and 3 showed mineralization within the tumor on CT. Eighty-eight patients underwent CT-guided biopsy with a diagnostic accuracy rate of 94.3%. Conclusions: Spinal GCTs might appear more radiologically atypical, and about 40% of the lesions may have at least 1 atypical feature. CT-guided biopsies are recommended for definitive diagnosis.

Giant Cell Tumors

1957 ◽  
Vol Original Series, Volume 48 (152 Suppl) ◽  
pp. 18-23
Keyword(s):  
Giant Cell ◽  
Giant Cell Tumors

Giant Cell Tumor of the Talar Neck

2007 ◽  
Vol 97 (3) ◽  
pp. 225-228 ◽  
Author(s):  
Hakan Selek ◽  
Hamza Özer ◽  
Sacit Turanli ◽  
Özlem Erdem
Keyword(s):  
Giant Cell Tumor ◽  
Giant Cell ◽  
Clinical Signs ◽  
Cell Tumor ◽  
Giant Cell Tumors ◽  
Radiographic Appearance ◽  
Aneurysmal Bone Cysts ◽  
Tumors Of Bone ◽  
Brown Tumors ◽  
Small Bones

We describe a patient with a giant cell tumor in the talar head and neck of the left foot who was diagnosed as having osteochondritis dissecans and treated with arthroscopic drilling in this same location 3 years earlier. Giant cell tumors can be confused with several conditions, including giant cell reparative granulomas, brown tumors, and aneurysmal bone cysts. Giant cell tumors of bone typically occur in the epiphysis of long bones, including the distal femur and proximal tibia. They are uncommonly found in the small bones of the foot or ankle, and talar involvement is rare. Despite this rarity, the radiographic appearance and clinical signs of talar lesions should be considered in the differential diagnosis of nontraumatic conditions in the foot. (J Am Podiatr Med Assoc 97(3): 225–228, 2007)

Sign in / Sign up

Export Citation Format

Share Document