Faculty Opinions recommendation of Kcne2 deletion uncovers its crucial role in thyroid hormone biosynthesis.

2009 ◽  
Author(s):  
Sissy Jhiang
Keyword(s):  
Thyroid Hormone ◽  
Crucial Role ◽  
Thyroid Hormone Biosynthesis ◽  
Hormone Biosynthesis

scholarly journals Kcne2 deletion uncovers its crucial role in thyroid hormone biosynthesis

2009 ◽  
Vol 15 (10) ◽  
pp. 1186-1194 ◽  
Author(s):  
Torsten K Roepke ◽  
Elizabeth C King ◽  
Andrea Reyna-Neyra ◽  
Monika Paroder ◽  
Kerry Purtell ◽  
...  
Keyword(s):  
Thyroid Hormone ◽  
Crucial Role ◽  
Thyroid Hormone Biosynthesis ◽  
Hormone Biosynthesis

The Impact of Iodine Excess on Thyroid Hormone Biosynthesis and Metabolism in Rats

2009 ◽  
Vol 130 (1) ◽  
pp. 72-85 ◽  
Author(s):  
K. Wang ◽  
Y. N. Sun ◽  
J. Y. Liu ◽  
L. Zhang ◽  
Y. Ye ◽  
...  
Keyword(s):  
Thyroid Hormone ◽  
Iodine Excess ◽  
Thyroid Hormone Biosynthesis ◽  
Hormone Biosynthesis ◽  
The Impact

scholarly journals Bone Maturnity Delay in Congenital Hypothyroid

2020 ◽  
Vol 3 (1) ◽  
pp. 726-734
Author(s):  
Azhari Gani ◽  
Iskandar Zakaria
Keyword(s):  
Mental Retardation ◽  
Preterm Birth ◽  
Thyroid Hormone ◽  
Thyroid Gland ◽  
Physical Growth ◽  
Growth Disorders ◽  
Thyroid Dysgenesis ◽  
Thyroid Hormone Biosynthesis ◽  
Age Of Diagnosis ◽  
Hormone Biosynthesis

Congenital hypothyroid (CH) is a Hormonal disorder that can be caused by thyroid gland dysfunction and if not treated early on, will cause serious mental and physical growth disorders. CH is divided into permanent and transient forms which etiologically can be divided into primary, secondary or peripheral. Thyroid dysgenesis is the primary cause and 85% of permanent CH is with abnormalities of thyroid hormone biosynthesis from birth (dishormongeneses). The incidence of dysgenesis accounts for 10-15% of cases. Transient congenital thyroid occurs mostly in infants with preterm birth in low-iodine endemic areas. A study showed a permanent incidence of CH 1: 1500 and transient CH 1: 300 in one of the areas with iodine deficiency in Central Java.Survival analysis showed that the risk of developing mental retardation and delayed physical growth was greater at the age of diagnosis over 1 year.

scholarly journals NADPH oxidases (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database

2019 ◽  
Vol 2019 (4) ◽  
Author(s):  
Albert Van der Vliet
Keyword(s):  
Reactive Oxygen Species ◽  
Hydrogen Peroxide ◽  
Thyroid Hormone ◽  
Thyroid Gland ◽  
Oxygen Species ◽  
Nadph Oxidases ◽  
Thyroid Hormone Biosynthesis ◽  
Production Of Hydrogen ◽  
Nadph Oxidase Complex ◽  
Hormone Biosynthesis

The two DUOX enzymes were originally identified as participating in the production of hydrogen peroxide as a pre-requisite for thyroid hormone biosynthesis in the thyroid gland [6].NOX enzymes function to catalyse the reduction of molecular oxygen to superoxide and various other reactive oxygen species (ROS). They are subunits of the NADPH oxidase complex.

Congenital Hypothyroidism

2017 ◽  
Author(s):  
Mary Lee Gregory
Keyword(s):  
Thyroid Hormone ◽  
Congenital Hypothyroidism ◽  
Hormone Treatment ◽  
Thyroid Stimulating Hormone ◽  
Congenital Defects ◽  
Central Hypothyroidism ◽  
Severe Intellectual Disability ◽  
Iodine Supplementation ◽  
Thyroid Hormone Biosynthesis ◽  
Hormone Biosynthesis

Congenital hypothyroidism (CH) results from the effects of insufficient thyroid hormone on the developing fetus and infant, and is characterized by severe intellectual disability and growth inhibition. CH can result from maternal iodine deficiency, which can be abolished by appropriate dietary iodine supplementation. Alternately, CH may be caused by congenital defects of the thyroid gland and thyroid hormone biosynthesis abnormalities (primary congenital hypothyroidism), or by “central hypothyroidism,” in which the brain produces insufficient thyroid stimulating hormone. Treatment of these latter etiologies requires administration of thyroid hormone.

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