Faculty Opinions recommendation of Toll-like receptor 4 signaling by follicular dendritic cells is pivotal for germinal center onset and affinity maturation.

2010 ◽  
Author(s):  
Dan Conrad
Keyword(s):  
Dendritic Cells ◽  
Germinal Center ◽  
Affinity Maturation ◽  
Follicular Dendritic Cells ◽  
Toll Like Receptor ◽  
Toll Like Receptor 4 ◽  
Follicular Dendritic

scholarly journals Toll-like Receptor 4 Signaling by Follicular Dendritic Cells Is Pivotal for Germinal Center Onset and Affinity Maturation

Immunity ◽  
2010 ◽  
Vol 33 (1) ◽  
pp. 84-95 ◽  
Author(s):  
Alexandre Garin ◽  
Michael Meyer-Hermann ◽  
Mathias Contie ◽  
Marc Thilo Figge ◽  
Vanessa Buatois ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Germinal Center ◽  
Affinity Maturation ◽  
Follicular Dendritic Cells ◽  
Toll Like Receptor ◽  
Toll Like Receptor 4 ◽  
Follicular Dendritic

scholarly journals Germinal Center Initiation, Variable Gene Region Hypermutation, and Mutant B Cell Selection without Detectable Immune Complexes on Follicular Dendritic Cells

2000 ◽  
Vol 192 (7) ◽  
pp. 931-942 ◽  
Author(s):  
Lynn G. Hannum ◽  
Ann M. Haberman ◽  
Shannon M. Anderson ◽  
Mark J. Shlomchik
Keyword(s):  
Dendritic Cells ◽  
Immune Responses ◽  
B Cell ◽  
Immune Complexes ◽  
Germinal Center ◽  
Serum Antibody ◽  
Cell Formation ◽  
Immunoglobulin M ◽  
Follicular Dendritic Cells ◽  
Follicular Dendritic

Serum antibody (Ab) can play several roles during B cell immune responses. Among these is to promote the deposition of immune complexes (ICs) on follicular dendritic cells (FDCs). ICs on FDCs are generally thought to be critical for normal germinal center (GC) formation and the development and selection of memory B cells. However, it has been very difficult to test these ideas. To determine directly whether FDC-bound complexes do indeed function in these roles, we have developed a transgenic (Tg) mouse in which all B lymphocytes produce only the membrane-bound form of immunoglobulin M. Immune Tg mice have 10,000-fold less specific Ab than wild-type mice and lack detectable ICs on FDCs. Nonetheless, primary immune responses and the GC reaction in these mice are robust, suggesting that ICs on FDCs do not play critical roles in immune response initiation and GC formation. Moreover, as indicated by the presence and pattern of somatic mutations, memory cell formation and selection appear normal in these IC-deficient GCs.

scholarly journals Complementary Effects of TNF and Lymphotoxin on the Formation of Germinal Center and Follicular Dendritic Cells

2001 ◽  
Vol 166 (1) ◽  
pp. 330-337 ◽  
Author(s):  
Yang Wang ◽  
Jing Wang ◽  
Yonglian Sun ◽  
Qiang Wu ◽  
Yang-Xin Fu
Keyword(s):  
Dendritic Cells ◽  
Germinal Center ◽  
Follicular Dendritic Cells ◽  
Follicular Dendritic

Human follicular dendritic cells promote germinal center B cell survival by providing prostaglandins

2013 ◽  
Vol 55 (3-4) ◽  
pp. 418-423 ◽  
Author(s):  
Jini Kim ◽  
Seungkoo Lee ◽  
Young-Myeong Kim ◽  
Doo-Il Jeoung ◽  
Jongseon Choe
Keyword(s):  
Dendritic Cells ◽  
B Cell ◽  
Cell Survival ◽  
Germinal Center ◽  
Follicular Dendritic Cells ◽  
B Cell Survival ◽  
Germinal Center B Cell ◽  
Follicular Dendritic
Sign in / Sign up

Export Citation Format

Share Document