Faculty Opinions recommendation of Risk of colorectal adenoma and carcinoma after colectomy for colorectal cancer in patients meeting Amsterdam criteria.

2010 ◽  
Author(s):  
Heidi K Chua ◽  
Kellie Mathis
Keyword(s):  
Colorectal Cancer ◽  
Colorectal Adenoma ◽  
Amsterdam Criteria

Risk of Colorectal Adenoma and Carcinoma After Colectomy for Colorectal Cancer in Patients Meeting Amsterdam Criteria

2010 ◽  
Vol 128 ◽  
pp. 105-112 ◽  
Author(s):  
Matthew F. Kalady ◽  
Ellen McGannon ◽  
Jon D. Vogel ◽  
Elena Manilich ◽  
Victor W. Fazio ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Colorectal Adenoma ◽  
Amsterdam Criteria

scholarly journals Cumulative risks of colorectal cancer in Han Chinese patients with Lynch syndrome in Taiwan

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Abram Bunya Kamiza ◽  
Wen-Chang Wang ◽  
Jeng-Fu You ◽  
Reiping Tang ◽  
Huei-Tzu Chien ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Lynch Syndrome ◽  
Cumulative Risk ◽  
Germline Mutations ◽  
Han Chinese ◽  
Chinese Patients ◽  
Mutation Carriers ◽  
Amsterdam Criteria ◽  
Cumulative Risks ◽  
Age And Sex

AbstractPatients with Lynch syndrome have a high risk of colorectal cancer (CRC). In this study, we estimated the age- and sex-specific cumulative risks of CRC in Han Chinese patients with Lynch syndrome caused by the pathogenic germline mutations in MLH1 or MSH2 in Taiwan. Based on 321 mutation carriers and 419 non-mutation carriers from 75 pedigrees collected in an Amsterdam criteria family registry in Taiwan, the age- and sex-specific cumulative risks of CRC in male carriers of mutation in MLH1 and MSH2 at the age of 70 years were 60.3% (95% confidence interval (CI) = 31.1%–89.9%) and 76.7% (95% CI = 37.2%–99.0%), respectively. For females, the cumulative risks of CRC at the age of 70 were estimated to be 30.6% (95% CI = 14.3%–57.7%) and 49.3% (95% CI = 21.9%–84.5%) in the carriers of MLH1 and MSH2 germline mutations, respectively. In conclusion, the cumulative risks of CRC at the age of 70 in the Han Chinese patients is higher in mutation carriers than non-mutation carriers and male mutation carriers have a higher cumulative risk of developing CRC than the female mutation carriers.

Aspirin, ibuprofen, and reduced risk of advanced colorectal adenoma incidence and recurrence and colorectal cancer in the PLCO Cancer Screening Trial

Cancer ◽  
2021 ◽  
Author(s):  
Kenechukwu Chudy‐Onwugaje ◽  
Wen‐Yi Huang ◽  
L. Joseph Su ◽  
Mark P. Purdue ◽  
Christine C. Johnson ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Screening ◽  
Colorectal Adenoma ◽  
Cancer Screening Trial ◽  
Screening Trial ◽  
Reduced Risk

Genetic testing is important in families with a history suggestive of hereditary non-polyposis colorectal cancer even if the Amsterdam criteria are not fulfilled

1997 ◽  
Vol 84 (2) ◽  
pp. 233-237 ◽  
Author(s):  
N. E. Beck ◽  
I. P. M. Tomlinson ◽  
T. Homfray ◽  
S. V. Hodgson ◽  
C. J. Harocopos ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Genetic Testing ◽  
Amsterdam Criteria

PHENOTYPIC CHARACTERISTICS OF HEREDITARY NON-POLYPOSIS COLORECTAL CANCER BY THE AMSTERDAM CRITERIA: AN ASIAN PERSPECTIVE

2008 ◽  
Vol 78 (7) ◽  
pp. 556-560 ◽  
Author(s):  
Min-Hoe Chew ◽  
Poh-Koon Koh ◽  
Kheng-Hong Ng ◽  
Jit-Fong Lim ◽  
Kok-Sun Ho ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Phenotypic Characteristics ◽  
Amsterdam Criteria

scholarly journals Association of visceral adiposity and insulin resistance with colorectal adenoma and colorectal cancer

2019 ◽  
Vol 17 (3) ◽  
pp. 404-412 ◽  
Author(s):  
In Sub Jung ◽  
Cheol Min Shin ◽  
Sung Jae Park ◽  
Young Soo Park ◽  
Hyuk Yoon ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Insulin Resistance ◽  
Colorectal Adenoma ◽  
Visceral Adiposity

scholarly journals The Effects of Family History of Colorectal Cancer on the Development of Colorectal Adenoma

2012 ◽  
Vol 60 (1) ◽  
pp. 36 ◽  
Author(s):  
Min Young Choi ◽  
Byeong Gwan Kim ◽  
Ji Won Kim ◽  
Kook Lae Lee ◽  
Ji Bong Jeong ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Family History ◽  
Colorectal Adenoma ◽  
History Of

scholarly journals Role of Vitamin D in Preventing Colorectal Carcinogenesis

2021 ◽  
Vol 11 ◽  
pp. 123-133
Author(s):  
Fauzan Herdian ◽  
Fahmi Radityamurti ◽  
Tiara Bunga Mayang Permata ◽  
Handoko Handoko ◽  
Henry Kodrat ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Vitamin D ◽  
Gene Transcription ◽  
Colorectal Adenoma ◽  
Relevant Literature ◽  
Colorectal Carcinogenesis ◽  
Signalling Pathways ◽  
Original Research ◽  
Metastatic Progression ◽  
Vitamin D Levels

Introduction: Colorectal carcinoma is one of the cancers with a high disease burden globally. Previous observational studies have found a connection between colorectal cancer incidence with sunlight exposure and vitamin D levels. Subsequent studies investigated this relationship further and found various anti-tumoral pathways regulated by vitamin D in colorectal tissue. This paper aims to elucidate the actions of those pathways in preventing the malignant transformation of the colorectal cell by reviewing relevant literature. Methods: A search was conducted on several medical literature electronic databases for original research studying the effects of vitamin D treatment on colorectal adenoma and colorectal cancer and its underlying anti-tumoral mechanism. A total of 122 studies were included for evaluation. Results: Twenty-seven studies passed for analysis. These in vitro and in vivo study reveals that vitamin D treatment can suppress cell proliferation, induce apoptosis, maintain cellular differentiation, reduce the pro-inflammatory response, inhibit angiogenesis, and hinder metastatic progression in colorectal cancer and colorectal adenoma cells by regulating associated gene transcription or directly prevents activation of selected signalling pathways. Five studies have also shown that adding calcium to vitamin D treatment increases the anti-tumoral activity of vitamin D through cross-talk between both of their pathways. Conclusion: Vitamin D could potentially impede colorectal cancer transformation and growth through interaction with various signalling pathways and regulating gene transcription. Further clinical studies are needed to confirm whether vitamin D can be used as the basis of targeted colorectal cancer therapy using its inherent anti-tumoral properties.

Sign in / Sign up

Export Citation Format

Share Document