Faculty Opinions recommendation of Reducing excessive GABA-mediated tonic inhibition promotes functional recovery after stroke.

2011 ◽  
Author(s):  
Beverley Orser ◽  
Dianshi Wang
Keyword(s):  
Functional Recovery ◽  
Tonic Inhibition

scholarly journals Reducing excessive GABA-mediated tonic inhibition promotes functional recovery after stroke

Nature ◽  
2010 ◽  
Vol 468 (7321) ◽  
pp. 305-309 ◽  
Author(s):  
Andrew N. Clarkson ◽  
Ben S. Huang ◽  
Sarah E. MacIsaac ◽  
Istvan Mody ◽  
S. Thomas Carmichael
Keyword(s):  
Functional Recovery ◽  
Tonic Inhibition

scholarly journals GAT3 selective substrate l-isoserine upregulates GAT3 expression and increases functional recovery after a focal ischemic stroke in mice

2017 ◽  
Vol 39 (1) ◽  
pp. 74-88 ◽  
Author(s):  
Maria EK Lie ◽  
Emma K Gowing ◽  
Nina B Johansen ◽  
Nils Ole Dalby ◽  
Louise Thiesen ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Functional Recovery ◽  
Surface Expression ◽  
Tonic Inhibition ◽  
Stroke Recovery ◽  
Gaba Uptake ◽  
Dependent Manner ◽  
Concentration Dependent Manner ◽  
Post Stroke ◽  
Long Term Treatment

Ischemic stroke triggers an elevation in tonic GABA inhibition that impairs the ability of the brain to form new structural and functional cortical circuits required for recovery. This stroke-induced increase in tonic inhibition is caused by impaired GABA uptake via the glial GABA transporter GAT3, highlighting GAT3 as a novel target in stroke recovery. Using a photothrombotic stroke mouse model, we show that GAT3 protein levels are decreased in peri-infarct tissue from 6 h to 42 days post-stroke. Prior studies have shown that GAT substrates can increase GAT surface expression. Therefore, we aimed to assess whether the GAT3 substrate, L-isoserine, could increase post-stroke functional recovery. L-Isoserine (38 µM or 380 µM) administered directly into the infarct from day 5 to 32 post-stroke, significantly increased motor performance in the grid-walking and cylinder tasks in a concentration-dependent manner, without affecting infarct volumes. Additionally, L-isoserine induced a lasting increase in GAT3 expression in peri-infarct regions accompanied by a small decrease in GFAP expression. This study is the first to show that a GAT3 substrate can increase GAT3 expression and functional recovery after focal ischemic stroke following a delayed long-term treatment. We propose that enhancing GAT3-mediated uptake dampens tonic inhibition and promotes functional recovery after stroke.

Cardiomyocyte-specific overexpression of type 5 phosphodiesterase impairs functional recovery after myocardial infarction

2008 ◽  
Vol 7 ◽  
pp. 206-206
Author(s):  
P POKREISZ ◽  
A VANDENBERGH ◽  
V BITO ◽  
G MARSBOOM ◽  
S VANDENWIJNGAERT ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Functional Recovery

Obesity Is Associated With Poorer Functional Recovery Following Knee Surgery

2007 ◽  
Author(s):  
Patricia H. Rosenberger ◽  
Robert D. Kerns ◽  
Peter Jokl ◽  
Jeannette R. Ickovics
Keyword(s):  
Functional Recovery ◽  
Knee Surgery
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