Faculty Opinions recommendation of Association between common variants near the melanocortin 4 receptor gene and severe antipsychotic drug-induced weight gain.

The study presents the results of research on fattening and meat qualities of store pigs of large white breed of different intra-breeding differentiation by the gene of melanocortin-4 receptor (MC4R). The study calculated the economic efficiency of animals of different genotypes. The following fattening and meat qualities were evaluated: average daily increase in live weight during the period of control fattening, g; age of live weight 100 kg, days; fat thickness at the level of 6-7 thoracic vertebrae, mm; the length of the cooled carcass, cm; length of bacon half of chilled half-carcass, cm. It was established that store pigs of controlled population at the age of reaching live weight of 100 kg, fat thickness at the level of 6-7 thoracic vertebrae, and length of chilled carcass exceed the minimum requirements of the elite class by 13.69%. A significant difference between animals of different genotypes by the gene of the melanocortin-4 receptor (MC4RAA, MC4RAG) was established according to the average daily live weight gain during the control fattening period (4.24%, P <0.01), the age of reaching a live weight of 100 kg (2.18%, P <0,01), fat thickness at the level of 6–7 thoracic vertebrae (8,45%, P <0,05), length of chilled carcass (2,26%, P <0,001), length of bacon half of chilled half carcass (3.36%, P <0.001) and selection index (SI) (18.92%, P <0.05). Significant correlations in animals of different genotypes by the melanocortin-4 receptor gene (MC4RAA, MC4RAG) were identified regarding the following features: average daily live weight gain during the control period of fattening × age of 100 kg live weight (-0.475 – -0.853), average daily live weight for the period of control fattening × SI (+0.686 - +0.770), SI × age of reaching live weight 100 kg (+0.515 – -0.721), SI × fat thickness at the level of 6-7 thoracic vertebrae (-0.944 – -0.885), length of chilled carcass × length of bacon half of chilled carcass (+0.899 – +0.861). The maximum increase in additional products was obtained from the sale of young pigs by the gene for the melanocortin-4 receptor MC4RAG – +2.02%.

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Faculty Opinions recommendation of The role of thermogenesis in antipsychotic drug-induced weight gain.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1148188.605325 ◽

2009 ◽

Author(s):

Shaun Morrison ◽

Christopher Madden

Keyword(s):

Weight Gain ◽

Antipsychotic Drug ◽

Drug Induced

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Analysis of variation in the melanocortin-4 receptor gene (mc4r) in golden retriever dogs

Animal Genetics ◽

10.1111/j.1365-2052.2010.02049.x ◽

2010 ◽

Vol 41 (5) ◽

pp. 557-557 ◽

Cited By ~ 16

Author(s):

L. Van Den Berg ◽

S. M. Van Den Berg ◽

E. E. C. P. Martens ◽

H. A. W. Hazewinkel ◽

N. A. Dijkshoorn ◽

...

Keyword(s):

Receptor Gene ◽

Golden Retriever ◽

Melanocortin 4 Receptor ◽

Melanocortin 4 Receptor Gene ◽

Analysis Of Variation

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Melanocortin-4 Receptor Gene Variation Is Associated with Eating Behavior in Chilean Adults

Annals of Nutrition and Metabolism ◽

10.1159/000439092 ◽

2015 ◽

Vol 68 (1) ◽

pp. 35-41 ◽

Cited By ~ 15

Author(s):

Javier A. Vega ◽

Gloria Salazar ◽

María Isabel Hodgson ◽

Luis Rodrigo Cataldo ◽

Macarena Valladares ◽

...

Keyword(s):

Eating Behavior ◽

Emotional Eating ◽

Leptin Receptor ◽

Receptor Gene ◽

Pathogenic Mutation ◽

Gene Variation ◽

Mc4r Gene ◽

Melanocortin 4 Receptor ◽

Melanocortin 4 Receptor Gene ◽

Mc4r Rs17782313

Background/Aims: To evaluate the association between allelic variants of melanocortin receptors -3 and -4 (MC3R and MC4R, respectively) and leptin receptor (LEPR) genes with body mass index (BMI) and eating behavior. Methods: We selected 344 Chilean adults (57.8% women; age 39.1 ± 6.6 years) with a wide variation in BMI (30.3 ± 6.3 kg/m2). The Three-Factor Eating Questionnaire-R18 that measures uncontrolled eating (UE), emotional eating (EE) and cognitive restraint scores was adapted, validated and assessed for association with BMI. Genotypes were determined by polymerase chain reaction followed by restriction fragment length polymorphism techniques and Taqman assays. Results: Higher EE scores were found in obese vs. non-obese in both men (p = 0.01) and women (p < 0.001). UE scores were significantly associated with BMI only in women (p = 0.002). No significant differences in eating behavior scores or BMI were found by LEPR (rs1137101, rs8179183 and rs1137100 polymorphisms) or MC3R (rs3746619 and rs3827103). Carriers of the C allele for MC4R rs17782313 showed significantly higher scores of UE compared to non-carriers (2.3 ± 0.8 vs. 2.0 ± 0.7; p = 0.02). Additionally, we also report a monogenic case of obesity carrying the pathogenic mutation 449C>T (Thr150Ile) in MC4R gene with no apparent alterations in eating behavior scores. Conclusions: UE scores were higher in C-allele carriers of MC4R-rs17782313 compared to non-carriers.

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