P.3.c.041 −759 C/T polymorphism of the 5-HT2C receptor gene and antipsychotic drug-induced weight gain

2006 ◽  
Vol 16 ◽  
pp. S418-S419
Author(s):  
S.H. Ryu ◽  
W.S. Jang ◽  
E.Y. Cho ◽  
S.K. Kim ◽  
D.S. Lee ◽  
...  
Keyword(s):  
Weight Gain ◽  
Antipsychotic Drug ◽  
Receptor Gene ◽  
Drug Induced

PS20 - 95. Antipsychotic drug induced weight gain and insulin resistance: personality as a risk factor

2012 ◽  
Vol 10 (3) ◽  
pp. 166-167
Author(s):  
Simon Evers ◽  
Marianne Adema ◽  
Jacolien Graver ◽  
Gertjan van Dijk ◽  
Anton Scheurink
Keyword(s):  
Insulin Resistance ◽  
Risk Factor ◽  
Weight Gain ◽  
Antipsychotic Drug ◽  
Drug Induced

Liraglutide for the Treatment of Antipsychotic Drug-Induced Weight Gain—Reply

2017 ◽  
Vol 74 (11) ◽  
pp. 1173 ◽  
Author(s):  
Anders Fink-Jensen ◽  
Christoph U. Correll ◽  
Tina Vilsbøll
Keyword(s):  
Weight Gain ◽  
Antipsychotic Drug ◽  
Drug Induced

scholarly journals The obesity risk gene FTO influences body mass in chronic schizophrenia but not initial antipsychotic drug-induced weight gain in first-episode patients

2013 ◽  
Vol 16 (6) ◽  
pp. 1421-1425 ◽  
Author(s):  
Gavin P. Reynolds ◽  
Olga O. Yevtushenko ◽  
Sarah Gordon ◽  
Belen Arranz ◽  
Luis San ◽  
...  
Keyword(s):  
Body Weight ◽  
Weight Gain ◽  
Body Mass ◽  
Antipsychotic Drug ◽  
Antipsychotic Drugs ◽  
Individual Variability ◽  
First Episode ◽  
Chronic Patients ◽  
Drug Induced ◽  
Two Samples

Abstract Genetic factors contribute to the individual variability in weight gain caused by several antipsychotic drugs. The FTO gene is associated with obesity in the general population; we have investigated whether a common risk polymorphism (rs9939609) in this gene is associated with antipsychotic drug-induced weight gain and obesity. Two samples were studied: (1) 93 first-episode patients receiving antipsychotic drugs for the first time and having body weight monitored for up to 12 months; (2) 187 chronic patients with schizophrenia assessed for measures of obesity and metabolic dysfunction. No association of FTO genotype with weight gain was found in initially drug-naive patients. The chronically treated patients had a significant association of genotype with body mass index (BMI), reflected in associations with waist circumference, waist:hip ratio and the frequency of central obesity. These findings indicate that FTO genotype has a major effect on body weight determined by BMI in chronically treated patients with schizophrenia.

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