Faculty Opinions recommendation of The extent of degeneration of cruciate ligament is associated with chondrogenic differentiation in patients with osteoarthritis of the knee.

2012 ◽  
Author(s):  
Wael Kafienah ◽  
Helen Quasnichka
Keyword(s):  
Chondrogenic Differentiation ◽  
Cruciate Ligament ◽  
Osteoarthritis Of The Knee

scholarly journals Cruciate ligament integrity in osteoarthritis of the knee

2005 ◽  
Vol 52 (3) ◽  
pp. 794-799 ◽  
Author(s):  
Catherine L. Hill ◽  
Gwy Suk Seo ◽  
Daniel Gale ◽  
Saara Totterman ◽  
M. Elon Gale ◽  
...  
Keyword(s):  
Cruciate Ligament ◽  
Osteoarthritis Of The Knee

scholarly journals Value of passive anterior tibial subluxation on axial MRI in identifying anterior cruciate ligament functional deficiency in patients with advanced anteromedial osteoarthritis of the knee: a case-control study

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Yuzhang Tao ◽  
Siying Tang ◽  
Pei Zhao ◽  
Wenlong Yan ◽  
Aiguo Zhou ◽  
...  
Keyword(s):  
Anterior Cruciate Ligament ◽  
Cruciate Ligament ◽  
Intraclass Correlation ◽  
Area Under The Curve ◽  
Osteoarthritis Of The Knee ◽  
Diagnostic Ability ◽  
Standardized Protocol ◽  
Anterior Tibial ◽  
Anterior Cruciate ◽  
Control Study

Abstract Background A functionally deficient anterior cruciate ligament (ACL) is considered one of the contraindications in unicompartmental knee arthroplasty (UKA). But there is still a lack of standardized and reproducible methods to assess ACL functional integrity in patients with advanced anteromedial osteoarthritis of the knee (AMOA). This study explores the value of passive anterior tibial subluxation (PATS) on axial MRI in evaluating ACL status in this population. Methods Patients who met UKA indications between November 2017 and September 2020 were included and grouped into “intact” (ACLI) or “deficient” (ACLD) group according to their ACL status during surgery. All participants underwent MRI with a standardized protocol. The measurements of medial and lateral PATS were conducted on axial MRI, and the mean of them was calculated as global PATS. Then the reliability and diagnostic ability of PATS were determined. Results A total of 85 patients (45 for ACLI group, 40 for ACLD group) were included after selection. The measurements of PATS showed excellent intra- and inter-observer reliabilities (with an intraclass correlation coefficient of at least 0.986). The global PATS of the ACLI group was significantly lower than that of the ACLD group (− 2.30 ± 1.96 vs. 1.03 ± 1.96 mm, P<0.0001). The diagnostic ability of global PATS was good (area under the curve = 0.897), and a threshold of 1.2 mm had a specificity of 100%, a sensitivity of 55%, and an accuracy of 78.82%. Conclusion An axial global PATS of 1.2 mm on MRI is greatly specific for identifying a functionally deficient ACL in patients with advanced AMOA.

Comparative Analysis of Gene Expression between Cartilage and Menisci in Early-Phase Osteoarthritis of the Knee—An Animal Model Study

2017 ◽  
Vol 31 (07) ◽  
pp. 664-669 ◽  
Author(s):  
Jun Endo ◽  
Ryuichiro Akagi ◽  
Yuta Muramatsu ◽  
Atsuya Watanabe ◽  
Yorikazu Akatsu ◽  
...  
Keyword(s):  
Gene Expression ◽  
Early Phase ◽  
Cruciate Ligament ◽  
Gene Expression Pattern ◽  
Immunohistochemical Analysis ◽  
Cartilage Degeneration ◽  
Osteoarthritis Of The Knee ◽  
Animal Model Study ◽  
Male Wistar Rats ◽  
Surgically Induced

AbstractCartilage degeneration is believed to be the primary event in the development of osteoarthritis (OA). On the other hand, meniscal degeneration is observed with high prevalence, and some researchers have pointed out that pathological changes in menisci precede that of cartilage. The purpose of the present study is to investigate comprehensive gene expression pattern of cartilage and menisci in the initial phase of surgically induced OA and to compare them. Secondary OA was surgically induced in 10-week-old male Wistar rats by anterior cruciate ligament transection (ACLT). Articular cartilage and menisci were separately dissected from six ACLT- and six sham-operated rats. Each specimen was analyzed by microarray, histological, and immunohistochemical analysis 3 weeks after surgery. Of the 36,685 transcripts detectable by microarray, the number of upregulated transcripts in ACLT menisci was >2.5-fold compared with that in ACLT menisci in any given threshold. Cluster analysis using the Database for Annotation Visualization and Integrated Discovery (DAVID) showed genes related to OA, such as response to stimulus, angiogenesis, and apoptosis, which were predominantly found in menisci in ACLT rats. Representative proteases including Adamts2, 4, Mmp2, 12, 13, 14, 16, extracellular matrix genes including versican (Vcan), lumican (Lum), syndecan1 (Sdc1), and Prostaglandin endoperoxide synthase2 (Ptgs2) were up-regulated in menisci, but were not up-regulated in cartilage. Our results indicated that the molecular changes that occurred in menisci preceded those occurred in cartilage in the very early phase of surgically induced OA models.

scholarly journals Experimental animal models of post-traumatic osteoarthritis of the knee

2020 ◽  
Vol 12 (2) ◽  
Author(s):  
Gerardo E. Narez ◽  
Kristine M. Fischenich ◽  
Tammy L. Haut Donahue
Keyword(s):  
Animal Models ◽  
Experimental Animal ◽  
Cruciate Ligament ◽  
Experimental Models ◽  
Osteoarthritis Of The Knee ◽  
Experimental Animal Models ◽  
Tissue Degeneration ◽  
Post Traumatic ◽  
Anterior Cruciate ◽  
Large Animals

Due to the complex and dynamic nature of osteoarthritis (OA) and post-traumatic osteoarthritis (PTOA), animal models have been used to investigate the progression and pathogenesis of the disease. Researchers have used different experimental models to study OA and PTOA. With an emphasis on the knee joint, this review will compare and contrast the existing body of knowledge from anterior cruciate ligament transection models, meniscectomy models, combination models, as well as impact models in large animals to see how tissues respond to these different approaches to induce experimental OA and PTOA. The tissues discussed will include articular cartilage and the meniscus, with a focus on morphological, mechanical and histological assessments. The goal of this review is to demonstrate the progressive nature of OA by indicating the strong correlation between progressive tissue degeneration, change of mechanical properties, and loss of biochemical integrity and to highlight key differences between the most commonly used experimental animal models.

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